PMID- 25319380
OWN - NLM
STAT- MEDLINE
DCOM- 20170814
LR  - 20170814
IS  - 1476-5829 (Electronic)
IS  - 1476-5810 (Linking)
VI  - 15
IP  - 1
DP  - 2017 Mar
TI  - Utility of a multiple serum biomarker test to monitor remission status and 
      relapse in dogs with lymphoma undergoing treatment with chemotherapy.
PG  - 6-17
LID - 10.1111/vco.12123 [doi]
AB  - A blinded retrospective study was conducted to investigate remission and 
      recurrence of lymphoma in dogs receiving chemotherapy. The objective was to 
      compare clinicians' assessment using palpation and cytology to the results of 
      serum biochemical tests for haptoglobin (Hapt) and C-reactive protein (C-RP). 
      These biochemical test results were combined using a diagnostic algorithm 
      developed using data from 344 individual dogs. This multivariate approach, termed 
      the canine lymphoma blood test (cLBT), was used to follow 57 dogs during and 
      after treatment. cLBT of remission and recurrence compared well with clinicians' 
      assessment and differentiated dogs in remission and those with recurring disease 
      before appearance of lymphadenopathy (P < 0.001). The cLBT demonstrated 
      prognostic potential based on pre-treatment values on dogs with shorter survival 
      times and on those achieving the lowest cLBT score during treatment that showed 
      longer survival times. The test, therefore, demonstrates potential to assist in 
      monitoring treatment of canine lymphoma.
CI  - (c) 2014 The Authors. Veterinary and Comparative Oncology published by John Wiley & 
      Sons Ltd.
FAU - Alexandrakis, I
AU  - Alexandrakis I
AD  - Avacta Animal Health Unit 651, Thorp Arch Estate, Wetherby, LS23 7FZ, UK.
FAU - Tuli, R
AU  - Tuli R
AD  - Avacta Animal Health Unit 651, Thorp Arch Estate, Wetherby, LS23 7FZ, UK.
FAU - Ractliffe, S C
AU  - Ractliffe SC
AD  - Avacta Animal Health Unit 651, Thorp Arch Estate, Wetherby, LS23 7FZ, UK.
FAU - Tappin, S W
AU  - Tappin SW
AD  - Dick White Referrals Station Farm, Cambridgeshire, CB8 0UH, United Kingdom.
FAU - Foale, R D
AU  - Foale RD
AD  - Dick White Referrals Station Farm, Cambridgeshire, CB8 0UH, United Kingdom.
FAU - Roos, A
AU  - Roos A
AD  - Dierenkliniek Korte Akkeren, Gouda, Netherlands.
FAU - Slater, K J
AU  - Slater KJ
AD  - Avacta Animal Health Unit 651, Thorp Arch Estate, Wetherby, LS23 7FZ, UK.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20141015
PL  - England
TA  - Vet Comp Oncol
JT  - Veterinary and comparative oncology
JID - 101185242
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Haptoglobins)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Algorithms
MH  - Animals
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Biomarkers, Tumor/*blood
MH  - C-Reactive Protein/analysis
MH  - Dog Diseases/*blood/drug therapy/pathology
MH  - Dogs
MH  - Female
MH  - Haptoglobins/analysis
MH  - Lymphoma/blood/drug therapy/pathology/*veterinary
MH  - Male
MH  - Multivariate Analysis
MH  - Neoplasm Recurrence, Local/blood/*veterinary
MH  - Netherlands
MH  - Prognosis
MH  - Remission Induction
MH  - Retrospective Studies
OTO - NOTNLM
OT  - algorithm
OT  - canine
OT  - chemotherapy
OT  - lymphoma
OT  - monitoring
EDAT- 2014/10/17 06:00
MHDA- 2017/08/15 06:00
CRDT- 2014/10/17 06:00
PHST- 2013/11/29 00:00 [received]
PHST- 2014/09/09 00:00 [revised]
PHST- 2014/09/16 00:00 [accepted]
PHST- 2014/10/17 06:00 [pubmed]
PHST- 2017/08/15 06:00 [medline]
PHST- 2014/10/17 06:00 [entrez]
AID - 10.1111/vco.12123 [doi]
PST - ppublish
SO  - Vet Comp Oncol. 2017 Mar;15(1):6-17. doi: 10.1111/vco.12123. Epub 2014 Oct 15.