PMID- 2531971
OWN - NLM
STAT- MEDLINE
DCOM- 19900125
LR  - 20190824
IS  - 0065-4299 (Print)
IS  - 0065-4299 (Linking)
VI  - 28
IP  - 3-4
DP  - 1989 Nov
TI  - Antagonistic action of naloxone on central histamine receptors-stimulated 
      corticosterone secretion in rats under stress.
PG  - 159-63
AB  - In rats under a mild stress of restraint the interaction between central opioid 
      receptors and histaminergic stimulation of the pituitary-adrenocortical activity 
      was investigated indirectly through corticosterone secretion. In order to avoid a 
      possible direct action on adrenal glands, all the tested drugs were administered 
      intracerebroventricularly (icv). Naloxone an opioid antagonist and cimetidine, a 
      H2- and mepyramine a H1-receptor antagonists were given 15 min before histamine 
      and histamine agonists. One hour after histaminergic drug injection the rats were 
      restrained for 10 min and decapitated. Histamine, 2-pyridylethylamine (PEA), a 
      histamine H1-receptor agonist, and 4-methylhistamine (MeHA) and dimaprit, 
      H2-receptor agonists, significantly intensified the stress-induced increase in 
      serum corticosterone levels. Naloxone, given alone icv or ip, did not 
      substantially alter the stress-induced corticosterone response. Like mepyramine 
      naloxone abolished the corticosterone response to PEA in stressed rats. Naloxone 
      also decreased significantly, though not totally, the corticosterone response to 
      MeHA, dimaprit and histamine, its efficiency being similar to that of cimetidine, 
      a H2-receptor antagonist. These results suggest that in stressed rats central 
      opioid receptors are considerably involved in the histamine H1-receptor - and, to 
      a lesser degree, in the H2-receptor stimulation of the 
      hypothalamo-pituitary-adrenocortical axis.
FAU - Gadek-Michalska, A
AU  - Gadek-Michalska A
AD  - Institute of Pharmacology, Polish Academy of Sciences, Krakow.
FAU - Bugajski, J
AU  - Bugajski J
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Agents Actions
JT  - Agents and actions
JID - 0213341
RN  - 0 (Methylhistamines)
RN  - 0 (Pyridines)
RN  - 0 (Receptors, Histamine)
RN  - 0 (Receptors, Histamine H1)
RN  - 0 (Receptors, Histamine H2)
RN  - 36B82AMQ7N (Naloxone)
RN  - 54ST71P9EE (4-methylhistamine)
RN  - 80061L1WGD (Cimetidine)
RN  - 820484N8I3 (Histamine)
RN  - ATW1AH7OJ5 (2-(2-aminoethyl)pyridine)
RN  - GYV9AM2QAG (Thiourea)
RN  - HPE317O9TL (Pyrilamine)
RN  - W980KJ009P (Corticosterone)
RN  - ZZQ699148P (Dimaprit)
SB  - IM
MH  - Animals
MH  - Cimetidine/pharmacology
MH  - Corticosterone/blood/*metabolism
MH  - Dimaprit
MH  - Histamine/pharmacology
MH  - Male
MH  - Methylhistamines/pharmacology
MH  - Naloxone/*pharmacology
MH  - Pituitary-Adrenal System/drug effects
MH  - Pyridines/pharmacology
MH  - Pyrilamine/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Histamine/*drug effects
MH  - Receptors, Histamine H1/drug effects
MH  - Receptors, Histamine H2/drug effects
MH  - Restraint, Physical
MH  - Stress, Physiological/*metabolism
MH  - Thiourea/pharmacology
OID - NASA: 90086425
EDAT- 1989/11/01 00:00
MHDA- 1989/11/01 00:01
CRDT- 1989/11/01 00:00
PHST- 1989/11/01 00:00 [pubmed]
PHST- 1989/11/01 00:01 [medline]
PHST- 1989/11/01 00:00 [entrez]
AID - 10.1007/BF01967395 [doi]
PST - ppublish
SO  - Agents Actions. 1989 Nov;28(3-4):159-63. doi: 10.1007/BF01967395.