PMID- 25319871
OWN - NLM
STAT- MEDLINE
DCOM- 20150716
LR  - 20221207
IS  - 1099-1077 (Electronic)
IS  - 0885-6222 (Linking)
VI  - 29
IP  - 6
DP  - 2014 Nov
TI  - Human Rho guanine nucleotide exchange factor 11 gene is associated with 
      schizophrenia in a Japanese population.
PG  - 552-8
LID - 10.1002/hup.2435 [doi]
AB  - OBJECTIVE: The human Rho guanine nucleotide exchange factor 11 (ARHGEF11) gene is 
      one of the candidate genes for type 2 diabetes mellitus (T2DM). ARHGEF11 is 
      mapped to chromosome 1q21, which has susceptible risk loci for T2DM and 
      schizophrenia. We hypothesized that ARHGEF11 contributes to the pathogenesis of 
      schizophrenia. METHOD: We selected eight single nucleotide polymorphisms of 
      ARHGEF11 that had significant associations with T2DM for a case-control 
      association study of 490 patients with schizophrenia and 500 age-matched and 
      sex-matched controls. RESULTS: We did not find any differences in allelic, 
      genotypic associations, or minor allele frequencies with schizophrenia. Analysis 
      of the rs6427340-rs6427339 haplotype and the rs822585-rs6427340-rs6427339 
      haplotype combination provided significant evidence of an association with 
      schizophrenia (global permutations p = 0.00047 and 0.0032, respectively). C-C of 
      the rs6427340-rs6427339 haplotype and A-C-C of the rs822585-rs6427340-rs6427339 
      haplotype carried higher risk factors for schizophrenia (permutation p = 0.0010 
      and 0.0018, respectively). A-C-T of the rs822585-rs6427340-rs6427339 haplotype 
      had a possible protective effect (permutation p = 0.031). CONCLUSION: These 
      results provide new evidence that ARHGEF11 may constitute a risk factor for 
      schizophrenia.
CI  - Copyright (c) 2014 John Wiley & Sons, Ltd.
FAU - Mizuki, Yutaka
AU  - Mizuki Y
AD  - Department of Neuropsychiatry, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences.
FAU - Takaki, Manabu
AU  - Takaki M
FAU - Okahisa, Yuko
AU  - Okahisa Y
FAU - Sakamoto, Shinji
AU  - Sakamoto S
FAU - Kodama, Masafumi
AU  - Kodama M
FAU - Ujike, Hiroshi
AU  - Ujike H
FAU - Uchitomi, Yosuke
AU  - Uchitomi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141015
PL  - England
TA  - Hum Psychopharmacol
JT  - Human psychopharmacology
JID - 8702539
RN  - 0 (ARHGEF11 protein, human)
RN  - 0 (Rho Guanine Nucleotide Exchange Factors)
SB  - IM
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - Japan
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Rho Guanine Nucleotide Exchange Factors/*genetics
MH  - Risk
MH  - Schizophrenia/*genetics
OTO - NOTNLM
OT  - ARHGEF11
OT  - case-control study
OT  - schizophrenia
OT  - type 2 diabetes mellitus
EDAT- 2014/10/17 06:00
MHDA- 2015/07/17 06:00
CRDT- 2014/10/17 06:00
PHST- 2013/08/30 00:00 [received]
PHST- 2014/07/04 00:00 [revised]
PHST- 2014/08/13 00:00 [accepted]
PHST- 2014/10/17 06:00 [entrez]
PHST- 2014/10/17 06:00 [pubmed]
PHST- 2015/07/17 06:00 [medline]
AID - 10.1002/hup.2435 [doi]
PST - ppublish
SO  - Hum Psychopharmacol. 2014 Nov;29(6):552-8. doi: 10.1002/hup.2435. Epub 2014 Oct 
      15.