PMID- 25320417
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141016
LR  - 20211021
IS  - 0046-8991 (Print)
IS  - 0973-7715 (Electronic)
IS  - 0046-8991 (Linking)
VI  - 54
IP  - 2
DP  - 2014 Jun
TI  - The Pseudomonas aeruginosa Mannose Sensitive Hamemagglutination Strain (PA-MSHA) 
      Induces a Th1-Polarizing Phenotype by Promoting Human Dendritic Cells Maturation.
PG  - 163-9
LID - 10.1007/s12088-013-0436-6 [doi]
AB  - Pseudomonas aeruginosa mannose sensitive hamemagglutination strain (PA-MSHA) is a 
      kind of peritrichous P. aeruginosa strain with MSHA fimbriae and has been shown 
      to activate kinds of immunocytes. Dendritic cells (DCs) are specialized 
      antigen-presenting cells required for the stimulating and priming CD4(+) T cells 
      toward the T helper cell type 1 (Th1), Th2 and other different phenotypes. 
      PA-MSHA effecting on Th1 remains an important missing link. Here we demonstrated 
      that PA-MSHA augmented monocytes derived-dendritic cells (Mo-DCs) expression of 
      HLA-DR, co-stimulatory and adhesion molecules, and induced Th1-promoting 
      interleukin-12 and tumor necrosis factor alpha secretion, in addition, PA-MSHA 
      treated Mo-DCs displayed lesser endocytic capacity. Furthermore, in mixed 
      lymphocyte reactions, allostimulatory capacity of Mo-DCs was enhanced by PA-MSHA, 
      CD4(+) T cells stimulated by PA-MSHA -activated Mo-DCs showed a Th1-polarized 
      cytokine production, increasing secretion of IFN-gamma and decreasing secretion of 
      IL-10 and IL-4. Our findings identified PA-MSHA as an important exogenous factor 
      that induced DCs maturation toward a Th1-promoting phenotype.
FAU - Zhang, Yunyan
AU  - Zhang Y
AD  - Department of Stomatology, Guangzhou Women and Children's Medical Center, 
      Guangzhou, China.
FAU - Wang, Hongtao
AU  - Wang H
AD  - Department of Stomatology, Guangzhou Women and Children's Medical Center, 
      Guangzhou, China.
FAU - Li, Youqiang
AU  - Li Y
AD  - Department of Laboratory Medicine, Guangdong Provincial Hospital of Chinese 
      Medicine, Guangzhou, China.
FAU - Chen, Ke
AU  - Chen K
AD  - Department of Stomatology, Guangzhou Women and Children's Medical Center, 
      Guangzhou, China.
FAU - Ye, Jinmei
AU  - Ye J
AD  - Department of Stomatology, Guangzhou Women and Children's Medical Center, 
      Guangzhou, China.
FAU - Liao, Xin
AU  - Liao X
AD  - Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun 
      Yat-sen University, Guangzhou, China.
FAU - Chen, Yiyang
AU  - Chen Y
AD  - Department of Stomatology, Guangzhou Women and Children's Medical Center, 
      Guangzhou, China.
FAU - Ran, Wei
AU  - Ran W
AD  - Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun 
      Yat-sen University, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20131029
PL  - India
TA  - Indian J Microbiol
JT  - Indian journal of microbiology
JID - 0374703
PMC - PMC4188503
OTO - NOTNLM
OT  - Dendritic cells
OT  - Differentiation of Th cell
OT  - Immunomodulatory capacity
OT  - PA-MSHA strain
EDAT- 2014/10/17 06:00
MHDA- 2014/10/17 06:01
PMCR- 2015/06/01
CRDT- 2014/10/17 06:00
PHST- 2013/07/29 00:00 [received]
PHST- 2013/10/21 00:00 [accepted]
PHST- 2014/10/17 06:00 [entrez]
PHST- 2014/10/17 06:00 [pubmed]
PHST- 2014/10/17 06:01 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - 436 [pii]
AID - 10.1007/s12088-013-0436-6 [doi]
PST - ppublish
SO  - Indian J Microbiol. 2014 Jun;54(2):163-9. doi: 10.1007/s12088-013-0436-6. Epub 
      2013 Oct 29.