PMID- 25321318 OWN - NLM STAT- MEDLINE DCOM- 20150720 LR - 20141110 IS - 1526-4602 (Electronic) IS - 1525-7797 (Linking) VI - 15 IP - 11 DP - 2014 Nov 10 TI - Mold-templated inorganic-organic hybrid supraparticles for codelivery of drugs. PG - 4146-51 LID - 10.1021/bm501171j [doi] AB - This paper reports a facile and robust mold-templated technique for the assembly of mesoporous silica (MS) supraparticles and demonstrates their potential as vehicles for codelivery of brain-derived neurotrophic factor (BDNF) and dexamethasone (DEX). The MS supraparticles are assembled using gelatin as a biodegradable adhesive to bind and cross-link the particles. Microfabricated molds made of polydimethylsiloxane are used to control the size and shape of the supraparticles. The obtained mesoporous silica-gelatin hybrid supraparticles (MSG-SPs) are stable in water as well as in organic solvents, such as dimethyl sulfoxide, and efficiently coencapsulate both BDNF and DEX. The MSG-SPs also exhibit sustained release kinetics in simulated physiological conditions (>30 days), making them potential candidates for long-term delivery of therapeutics to the inner ear. FAU - Maina, James W AU - Maina JW AD - ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, double daggerDepartment of Chemical and Biomolecular Engineering, section signDepartment of Otolaryngology, and parallelDepartment of Medical Bionics, The University of Melbourne , Parkville, Victoria 3010, Australia. FAU - Cui, Jiwei AU - Cui J FAU - Bjornmalm, Mattias AU - Bjornmalm M FAU - Wise, Andrew K AU - Wise AK FAU - Shepherd, Robert K AU - Shepherd RK FAU - Caruso, Frank AU - Caruso F LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20141016 PL - United States TA - Biomacromolecules JT - Biomacromolecules JID - 100892849 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Drug Carriers) RN - 0 (Pharmaceutical Preparations) RN - 7S5I7G3JQL (Dexamethasone) SB - IM MH - Brain-Derived Neurotrophic Factor/administration & dosage/*chemistry MH - Dexamethasone/administration & dosage/*chemistry MH - Drug Carriers/administration & dosage/*chemistry MH - Drug Delivery Systems/*methods MH - *Particle Size MH - Pharmaceutical Preparations/administration & dosage/chemistry EDAT- 2014/10/17 06:00 MHDA- 2015/07/21 06:00 CRDT- 2014/10/17 06:00 PHST- 2014/10/17 06:00 [entrez] PHST- 2014/10/17 06:00 [pubmed] PHST- 2015/07/21 06:00 [medline] AID - 10.1021/bm501171j [doi] PST - ppublish SO - Biomacromolecules. 2014 Nov 10;15(11):4146-51. doi: 10.1021/bm501171j. Epub 2014 Oct 16.