PMID- 25322755
OWN - NLM
STAT- MEDLINE
DCOM- 20150619
LR  - 20221207
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 10
IP  - 6
DP  - 2014 Dec
TI  - Dual matrilineal geographic distribution of Korean type 2 diabetes 
      mellitus-associated -11,377 G adiponectin allele.
PG  - 2993-3002
LID - 10.3892/mmr.2014.2639 [doi]
AB  - The present study was performed to identify the susceptible single nucleotide 
      polymorphisms (SNPs) for the prediction of Korean type 2 diabetes mellitus (T2DM) 
      and to clarify the matrilineal origin of Korean T2DM‑specific SNPs. Fourteen SNPs 
      from the adiponectin (ADIPOQ), hepatocyte nuclear factor 4alpha, phosphoenolpyruvate 
      carboxykinase 1 and glucokinase genes in the Korean population were analyzed. 
      Only one SNP, ‑11,377 C/G on the ADIPOQ gene, was finally determined to be 
      responsible for the incidence of Korean T2DM (P=0.028). The G‑T‑T‑A haplotype at 
      positions ‑11,377, +45, +276 and +349 on the ADIPOQ gene was also associated with 
      a high incidence of Korean T2DM (P=0.023). In addition, the susceptibility of 
      Korean individuals to T2DM appears to be affected by their matrilineal origin. Of 
      note, the group of Southern origin, consisting of mitochondrial DNA 
      macrohaplogroups F and R, was predisposed to T2DM, whereas the group of Northern 
      origin, consisting of haplogroups A and Y, was resistant to T2DM. This implied 
      that the differential genetics between the two groups, which were formed from the 
      initial peopling of the proto‑Korean population via Southern and Northern routes 
      to the present time, may explain their differing susceptibility to T2DM. In 
      conclusion, from Southern Asia Northward, a matrilineal origin of Korean 
      individuals appears to be responsible for the prevalence of Korean T2DM caused by 
      the ‑11,377 G allele.
FAU - Choi, Jee-Hye
AU  - Choi JH
AD  - Department of Laboratory Medicine, College of Medicine, Chung-Ang University, 
      Dongjak-gu, Seoul 156-756, South Korea.
FAU - Min, Na Young
AU  - Min NY
AD  - Department of Life Science, College of Natural Science, Chung-Ang University, 
      Dongjak-gu, Seoul 156-756, South Korea.
FAU - Park, Sang Kil
AU  - Park SK
AD  - Department of Laboratory Medicine, College of Medicine, Chung-Ang University, 
      Dongjak-gu, Seoul 156-756, South Korea.
FAU - Gavaachimed, Lkhagvasuren
AU  - Gavaachimed L
AD  - Department of Science and Culture, Graduate School, Chung-Ang University, 
      Dongjak-gu, Seoul 156-756, South Korea.
FAU - Ko, Young Jong
AU  - Ko YJ
AD  - Department of Life Science, College of Natural Science, Chung-Ang University, 
      Dongjak-gu, Seoul 156-756, South Korea.
FAU - Han, Sung Hoon
AU  - Han SH
AD  - Department of Life Science, College of Natural Science, Chung-Ang University, 
      Dongjak-gu, Seoul 156-756, South Korea.
FAU - Kim, Kyung Yong
AU  - Kim KY
AD  - Department of Microbiology, College of Medicine, Chung-Ang University, 
      Dongjak-gu, Seoul 156-756, South Korea.
FAU - Kim, Kijung
AU  - Kim K
AD  - Department of Microbiology, College of Medicine, Chung-Ang University, 
      Dongjak-gu, Seoul 156-756, South Korea.
FAU - Lee, Kwang Ho
AU  - Lee KH
AD  - Department of Life Science, College of Natural Science, Chung-Ang University, 
      Dongjak-gu, Seoul 156-756, South Korea.
FAU - Park, Ae Ja
AU  - Park AJ
AD  - Department of Laboratory Medicine, College of Medicine, Chung-Ang University, 
      Dongjak-gu, Seoul 156-756, South Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141014
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Adiponectin)
SB  - IM
MH  - Adiponectin/*genetics
MH  - Alleles
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - Male
MH  - Polymorphism, Single Nucleotide/*genetics
EDAT- 2014/10/18 06:00
MHDA- 2015/06/20 06:00
CRDT- 2014/10/18 06:00
PHST- 2013/10/22 00:00 [received]
PHST- 2014/06/26 00:00 [accepted]
PHST- 2014/10/18 06:00 [entrez]
PHST- 2014/10/18 06:00 [pubmed]
PHST- 2015/06/20 06:00 [medline]
AID - 10.3892/mmr.2014.2639 [doi]
PST - ppublish
SO  - Mol Med Rep. 2014 Dec;10(6):2993-3002. doi: 10.3892/mmr.2014.2639. Epub 2014 Oct 
      14.