PMID- 25322828
OWN - NLM
STAT- MEDLINE
DCOM- 20150617
LR  - 20221207
IS  - 1938-2022 (Electronic)
IS  - 1938-2014 (Print)
IS  - 1938-2014 (Linking)
VI  - 6
IP  - 3
DP  - 2014
TI  - Streptozotocin-associated lymphopenia in cynomolgus monkeys.
PG  - e944441
LID - 10.4161/19382014.2014.944441 [doi]
LID - e944441
AB  - Streptozotocin (STZ) is used to induce diabetes in experimental animals. It has a 
      variety of adverse effects, ranging from nausea, emesis, and weight loss to liver 
      damage, renal failure, and metabolic acidosis. STZ also has effects on the immune 
      system, being associated with lymphopenia in rodents, the mechanism of which is 
      not fully understood. We present data on a significant STZ-associated reduction 
      in lymphocyte count in nonhuman primates. We report a significant reduction in 
      absolute lymphocyte count; in 2 monkeys, the lymphopenia persisted for >100 d. 
      However, a significant increase in absolute monocyte count was noted. 
      Furthermore, an increase in serum monocyte chemoattractant protein-1 (MCP-1) was 
      observed. The reduction in lymphocyte numbers may contribute to immunomodulation 
      that may be beneficial to a subsequent islet graft, and may reduce the need for 
      immunosuppressive therapy. The increase in monocytes and MCP-1, however, may be 
      detrimental to the islet graft. Studies are warranted to explore the mechanism by 
      which STZ has its effect.
FAU - Nagaraju, Santosh
AU  - Nagaraju S
AD  - Thomas E. Starzl Transplantation Institute; University of Pittsburgh Medical 
      Center ; Pittsburgh , PA USA.
FAU - Bertera, Suzanne
AU  - Bertera S
AD  - Division of Immunogenetics; Department of Pediatrics; Children's Hospital of 
      Pittsburgh; University of Pittsburgh Medical Center ; Pittsburgh , PA USA.
FAU - Funair, Amber
AU  - Funair A
AD  - Division of Immunogenetics; Department of Pediatrics; Children's Hospital of 
      Pittsburgh; University of Pittsburgh Medical Center ; Pittsburgh , PA USA.
FAU - Wijkstrom, Martin
AU  - Wijkstrom M
AD  - Thomas E. Starzl Transplantation Institute; University of Pittsburgh Medical 
      Center ; Pittsburgh , PA USA.
FAU - Trucco, Massimo
AU  - Trucco M
AD  - Division of Immunogenetics; Department of Pediatrics; Children's Hospital of 
      Pittsburgh; University of Pittsburgh Medical Center ; Pittsburgh , PA USA.
FAU - Cooper, David K C
AU  - Cooper DK
AD  - Thomas E. Starzl Transplantation Institute; University of Pittsburgh Medical 
      Center ; Pittsburgh , PA USA.
FAU - Bottino, Rita
AU  - Bottino R
AD  - Division of Immunogenetics; Department of Pediatrics; Children's Hospital of 
      Pittsburgh; University of Pittsburgh Medical Center ; Pittsburgh , PA USA.
LA  - eng
GR  - R21 AI074844/AI/NIAID NIH HHS/United States
GR  - U19 AI090959-01/AI/NIAID NIH HHS/United States
GR  - P30CA047904/CA/NCI NIH HHS/United States
GR  - U01 AI068642/AI/NIAID NIH HHS/United States
GR  - R21 A1074844/PHS HHS/United States
GR  - U19 AI090959/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Islets
JT  - Islets
JID - 101495366
RN  - 0 (Chemokine CCL2)
RN  - 0 (Glycated Hemoglobin A)
RN  - 5W494URQ81 (Streptozocin)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/blood
MH  - Diabetes Mellitus, Experimental/*blood
MH  - Glucose Tolerance Test
MH  - Glycated Hemoglobin/analysis
MH  - Lymphocyte Count
MH  - Lymphopenia/blood/*chemically induced
MH  - Macaca fascicularis
MH  - Streptozocin/*administration & dosage/adverse effects
PMC - PMC4292713
OTO - NOTNLM
OT  - STZ, streptozotocin
OT  - WBC, white blood cell
OT  - cynomolgus
OT  - diabetes
OT  - islets
OT  - lymphopenia
OT  - monkey
OT  - monocytes
OT  - pig
OT  - streptozotocin
EDAT- 2014/10/18 06:00
MHDA- 2015/06/18 06:00
PMCR- 2015/10/31
CRDT- 2014/10/18 06:00
PHST- 2014/10/18 06:00 [entrez]
PHST- 2014/10/18 06:00 [pubmed]
PHST- 2015/06/18 06:00 [medline]
PHST- 2015/10/31 00:00 [pmc-release]
AID - 944441 [pii]
AID - 10.4161/19382014.2014.944441 [doi]
PST - ppublish
SO  - Islets. 2014;6(3):e944441. doi: 10.4161/19382014.2014.944441.