PMID- 25323409
OWN - NLM
STAT- MEDLINE
DCOM- 20150715
LR  - 20141127
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 162
IP  - 1-3
DP  - 2014 Dec
TI  - Effects of chromium methionine supplementation on growth performance, serum 
      metabolites, endocrine parameters, antioxidant status, and immune traits in 
      growing pigs.
PG  - 134-41
LID - 10.1007/s12011-014-0147-9 [doi]
AB  - The effects of dietary chromium methionine (CrMet) on growth performance, serum 
      metabolites, endocrine parameters, antioxidant status, and immune traits in 
      growing pigs were investigated. A total of 180 crossbred pigs (30.18 +/- 0.28 kg 
      initial body mass) were randomly divided into five groups, each group with six 
      pens, six pigs per pen. Pigs were fed on the same basal diet supplemented with 0 
      (control), 100, 200, 400, and 800 mug/kg Cr from CrMet for 35 days. The results 
      showed that supplemental CrMet did not affect growth performance. Cr at 200-800 
      mug/kg significantly decreased serum glucose levels (P < 0.05), while other serum 
      metabolites were unaffected by Cr supplementation. Serum growth hormone (GH) 
      levels were significantly decreased by Cr addition (P < 0.05). Furthermore, serum 
      insulin-like growth factor I (IGF-I) levels were linearly decreased with 
      increased Cr dose, and a significant reduction was observed in pigs fed 800 mug/kg 
      Cr diets (P < 0.05). Serum immunoglobulin A, G, and M concentrations were 
      increased linearly with increased Cr dosage, and pigs fed 400 mug/kg Cr had 
      greater serum immunoglobulin M contents (P < 0.05). Cr at 400 mug/kg significantly 
      increased serum superoxide dismutase and total antioxidant capacity activities 
      (T-AOC) (P < 0.05). However, Cr at 800 mug/kg increased serum catalase activities, 
      while decreasing serum T-AOC contents (P < 0.05). Additionally, there was a 
      significant increase in serum malondialdehyde levels for pigs fed 800 mug/kg Cr 
      diets (P < 0.05). These results indicated that dietary supplementation CrMet 
      decreased serum glucose, GH, and IGF-I levels. Besides, supplemental 400 mug/kg Cr 
      as CrMet improved serum antioxidant status and immune responses, but additional 
      800 mug/kg Cr resulted in lipid peroxidation in growing pigs.
FAU - Tian, Yao-Yao
AU  - Tian YY
AD  - State Key Laboratory of Animal Nutrition, Ministry of Agriculture Feed Industry 
      Centre, China Agricultural University, Beijing, 100193, China.
FAU - Zhang, Li-Ying
AU  - Zhang LY
FAU - Dong, Bing
AU  - Dong B
FAU - Cao, Jun
AU  - Cao J
FAU - Xue, Jian-Xiang
AU  - Xue JX
FAU - Gong, Li-Min
AU  - Gong LM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141017
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 0 (Antioxidants)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0R0008Q3JB (Chromium)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - AE28F7PNPL (Methionine)
SB  - IM
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - Chromium/*pharmacology
MH  - Immunoglobulin G/blood
MH  - Immunoglobulin M/blood
MH  - Lipid Peroxidation/drug effects
MH  - Malondialdehyde/metabolism
MH  - Methionine/*pharmacology
MH  - Swine
EDAT- 2014/10/18 06:00
MHDA- 2015/07/16 06:00
CRDT- 2014/10/18 06:00
PHST- 2014/09/26 00:00 [received]
PHST- 2014/10/02 00:00 [accepted]
PHST- 2014/10/18 06:00 [entrez]
PHST- 2014/10/18 06:00 [pubmed]
PHST- 2015/07/16 06:00 [medline]
AID - 10.1007/s12011-014-0147-9 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2014 Dec;162(1-3):134-41. doi: 10.1007/s12011-014-0147-9. 
      Epub 2014 Oct 17.