PMID- 25323843
OWN - NLM
STAT- MEDLINE
DCOM- 20150916
LR  - 20150123
IS  - 1460-2377 (Electronic)
IS  - 0953-8178 (Linking)
VI  - 27
IP  - 2
DP  - 2015 Feb
TI  - Dendritic cells in humans--from fetus to adult.
PG  - 65-72
LID - 10.1093/intimm/dxu091 [doi]
AB  - The human immune system evolves continuously during development from the embryo 
      into the adult, reflecting the ever-changing environment and demands of our body. 
      This ability of our immune system to sense external cues and adapt as we develop 
      is just as important in the early tolerogenic environment of the fetus, as it is 
      in the constantly pathogen-challenged adult. Dendritic cells (DCs), the 
      professional antigen-sensing and antigen-presenting components of the immune 
      system, play a crucial role in this process where they act as sentinels, both 
      initiating and regulating immune responses. Here, we provide an overview of the 
      human immune system in the developing fetus and the adult, with a focus on DC 
      ontogeny and function during these discrete but intimately linked life stages.
CI  - (c) The Japanese Society for Immunology. 2014. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - McGovern, Naomi
AU  - McGovern N
AD  - Singapore Immunology Network, Agency for Science, Technology and Research, 8A 
      Biomedical Grove, IMMUNOS Building #3-4, BIOPOLIS, Singapore 138648, Singapore.
FAU - Chan, Jerry K Y
AU  - Chan JK
FAU - Ginhoux, Florent
AU  - Ginhoux F
AD  - Singapore Immunology Network, Agency for Science, Technology and Research, 8A 
      Biomedical Grove, IMMUNOS Building #3-4, BIOPOLIS, Singapore 138648, Singapore 
      Department of Reproductive Medicine, Division of Obstetrics and Gynaecology, KK 
      Women's and Children's Hospital, Singapore 229899, Singapore 
      florent_ginhoux@immunol.a-star.edu.sg.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20141016
PL  - England
TA  - Int Immunol
JT  - International immunology
JID - 8916182
SB  - IM
MH  - Adult
MH  - Antigen Presentation/*physiology
MH  - Dendritic Cells/cytology/*immunology
MH  - Fetal Development/*immunology
MH  - Fetus
MH  - Humans
MH  - Immune Tolerance/*physiology
OTO - NOTNLM
OT  - adult
OT  - dendritic cell
OT  - fetus
OT  - function
OT  - ontogeny
OT  - subset
EDAT- 2014/10/18 06:00
MHDA- 2015/09/17 06:00
CRDT- 2014/10/18 06:00
PHST- 2014/10/18 06:00 [entrez]
PHST- 2014/10/18 06:00 [pubmed]
PHST- 2015/09/17 06:00 [medline]
AID - dxu091 [pii]
AID - 10.1093/intimm/dxu091 [doi]
PST - ppublish
SO  - Int Immunol. 2015 Feb;27(2):65-72. doi: 10.1093/intimm/dxu091. Epub 2014 Oct 16.