PMID- 25324153
OWN - NLM
STAT- MEDLINE
DCOM- 20150909
LR  - 20220317
IS  - 1464-3685 (Electronic)
IS  - 0300-5771 (Print)
IS  - 0300-5771 (Linking)
VI  - 43
IP  - 6
DP  - 2014 Dec
TI  - Interaction between passive smoking and two HLA genes with regard to multiple 
      sclerosis risk.
PG  - 1791-8
LID - 10.1093/ije/dyu195 [doi]
AB  - BACKGROUND: The recently described interaction between smoking, human leukocyte 
      antigen (HLA) DRB1*15 and absence of HLA-A*02 with regard to multiple sclerosis 
      (MS) risk shows that the risk conveyed by smoking differs depending on genetic 
      background. We aimed to investigate whether a similar interaction exists between 
      passive smoking and HLA genotype. METHODS: We used one case-control study with 
      incident cases of MS (736 cases, 1195 controls) and one with prevalent cases (575 
      cases, 373 controls). Never-smokers with different genotypes and passive smoking 
      status were compared with regard to occurrence of MS, by calculating odds ratios 
      (ORs) with 95% confidence intervals (CIs). The potential interaction between 
      different genotypes and passive smoking was evaluated by calculating the 
      attributable proportion (AP) due to interaction. RESULTS: An interaction was 
      observed between passive smoking and carriage of HLA-DRB1*15 (AP 0.3, 95% CI 
      0.02-0.5 in the incident study, and AP 0.4, 95% CI 0.1-0.7 in the prevalent 
      study), as well as between passive smoking and absence of HLA-A*02. Compared with 
      non-smokers without any of these two genetic risk factors, non-exposed subjects 
      with the two risk genotypes displayed an OR of 4.5 (95% CI 3.3-6.1) whereas the 
      same genotype for subjects exposed to passive smoking rendered an OR of 7.7 (95% 
      CI 5.5-10.8). CONCLUSIONS: The risk of developing MS associated with different 
      HLA genotypes may be influenced by exposure to passive smoking. The finding 
      supports our hypothesis that priming of the immune response in the lungs may 
      subsequently lead to MS in people with a genetic susceptibility to the disease.
CI  - (c) The Author 2014; all rights reserved. Published by Oxford University Press on 
      behalf of the International Epidemiological Association.
FAU - Hedstrom, Anna Karin
AU  - Hedstrom AK
AD  - Institute of Environmental Medicine, and Neuroimmunology Unit, Karolinska 
      Institutet, Stockholm, Sweden, Division of Epidemiology, School of Public Health, 
      University of California, Berkeley, CA, USA, Kaiser Permanente Division of 
      Research, Oakland, CA, USA and Neuroimmunology Unit, Karolinska Institutet at 
      Karolinska University Hospital, Solna, Sweden anna.hedstrom@ki.se.
FAU - Bomfim, Izaura Lima
AU  - Bomfim IL
AD  - Institute of Environmental Medicine, and Neuroimmunology Unit, Karolinska 
      Institutet, Stockholm, Sweden, Division of Epidemiology, School of Public Health, 
      University of California, Berkeley, CA, USA, Kaiser Permanente Division of 
      Research, Oakland, CA, USA and Neuroimmunology Unit, Karolinska Institutet at 
      Karolinska University Hospital, Solna, Sweden.
FAU - Barcellos, Lisa F
AU  - Barcellos LF
AD  - Institute of Environmental Medicine, and Neuroimmunology Unit, Karolinska 
      Institutet, Stockholm, Sweden, Division of Epidemiology, School of Public Health, 
      University of California, Berkeley, CA, USA, Kaiser Permanente Division of 
      Research, Oakland, CA, USA and Neuroimmunology Unit, Karolinska Institutet at 
      Karolinska University Hospital, Solna, Sweden.
FAU - Briggs, Farren
AU  - Briggs F
AD  - Institute of Environmental Medicine, and Neuroimmunology Unit, Karolinska 
      Institutet, Stockholm, Sweden, Division of Epidemiology, School of Public Health, 
      University of California, Berkeley, CA, USA, Kaiser Permanente Division of 
      Research, Oakland, CA, USA and Neuroimmunology Unit, Karolinska Institutet at 
      Karolinska University Hospital, Solna, Sweden.
FAU - Schaefer, Catherine
AU  - Schaefer C
AD  - Institute of Environmental Medicine, and Neuroimmunology Unit, Karolinska 
      Institutet, Stockholm, Sweden, Division of Epidemiology, School of Public Health, 
      University of California, Berkeley, CA, USA, Kaiser Permanente Division of 
      Research, Oakland, CA, USA and Neuroimmunology Unit, Karolinska Institutet at 
      Karolinska University Hospital, Solna, Sweden.
FAU - Kockum, Ingrid
AU  - Kockum I
AD  - Institute of Environmental Medicine, and Neuroimmunology Unit, Karolinska 
      Institutet, Stockholm, Sweden, Division of Epidemiology, School of Public Health, 
      University of California, Berkeley, CA, USA, Kaiser Permanente Division of 
      Research, Oakland, CA, USA and Neuroimmunology Unit, Karolinska Institutet at 
      Karolinska University Hospital, Solna, Sweden.
FAU - Olsson, Tomas
AU  - Olsson T
AD  - Institute of Environmental Medicine, and Neuroimmunology Unit, Karolinska 
      Institutet, Stockholm, Sweden, Division of Epidemiology, School of Public Health, 
      University of California, Berkeley, CA, USA, Kaiser Permanente Division of 
      Research, Oakland, CA, USA and Neuroimmunology Unit, Karolinska Institutet at 
      Karolinska University Hospital, Solna, Sweden.
FAU - Alfredsson, Lars
AU  - Alfredsson L
AD  - Institute of Environmental Medicine, and Neuroimmunology Unit, Karolinska 
      Institutet, Stockholm, Sweden, Division of Epidemiology, School of Public Health, 
      University of California, Berkeley, CA, USA, Kaiser Permanente Division of 
      Research, Oakland, CA, USA and Neuroimmunology Unit, Karolinska Institutet at 
      Karolinska University Hospital, Solna, Sweden.
LA  - eng
GR  - R01 AI076544/AI/NIAID NIH HHS/United States
GR  - R01 NS049510/NS/NINDS NIH HHS/United States
GR  - R01NS0495103/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20141015
PL  - England
TA  - Int J Epidemiol
JT  - International journal of epidemiology
JID - 7802871
RN  - 0 (HLA-A*02 antigen)
RN  - 0 (HLA-A2 Antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*15 antigen)
RN  - 0 (Tobacco Smoke Pollution)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - Gene-Environment Interaction
MH  - Genetic Predisposition to Disease
MH  - HLA-A2 Antigen/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/epidemiology/*genetics
MH  - Protective Factors
MH  - Risk Factors
MH  - Smoking/*epidemiology
MH  - Sweden/epidemiology
MH  - Tobacco Smoke Pollution/*statistics & numerical data
MH  - Young Adult
PMC - PMC4276064
OTO - NOTNLM
OT  - HLA genotype
OT  - Multiple sclerosis
OT  - case-control study
OT  - gene-environment interaction
OT  - immunology
OT  - passive smoking
OT  - smoking
EDAT- 2014/10/18 06:00
MHDA- 2015/09/10 06:00
PMCR- 2014/10/14
CRDT- 2014/10/18 06:00
PHST- 2014/10/18 06:00 [entrez]
PHST- 2014/10/18 06:00 [pubmed]
PHST- 2015/09/10 06:00 [medline]
PHST- 2014/10/14 00:00 [pmc-release]
AID - dyu195 [pii]
AID - 10.1093/ije/dyu195 [doi]
PST - ppublish
SO  - Int J Epidemiol. 2014 Dec;43(6):1791-8. doi: 10.1093/ije/dyu195. Epub 2014 Oct 
      15.