PMID- 25324205
OWN - NLM
STAT- MEDLINE
DCOM- 20160620
LR  - 20211021
IS  - 1522-2594 (Electronic)
IS  - 0740-3194 (Print)
IS  - 0740-3194 (Linking)
VI  - 74
IP  - 4
DP  - 2015 Oct
TI  - Free-breathing combined three-dimensional phase sensitive late gadolinium 
      enhancement and T1 mapping for myocardial tissue characterization.
PG  - 1032-41
LID - 10.1002/mrm.25495 [doi]
AB  - PURPOSE: To develop a novel MR sequence for combined three-dimensional (3D) 
      phase-sensitive (PS) late gadolinium enhancement (LGE) and T1 mapping to allow 
      for simultaneous assessment of focal and diffuse myocardial fibrosis. METHODS: In 
      the proposed sequence, four 3D imaging volumes are acquired with different T1 
      weightings using a combined saturation and inversion preparation, after 
      administration of a gadolinium contrast agent. One image is acquired fully 
      sampled with the inversion time selected to null the healthy myocardial signal 
      (the LGE image). The other three images are three-fold under-sampled and 
      reconstructed using compressed sensing. An acquisition scheme with two 
      interleaved imaging cycles and joint navigator-gating of those cycles ensures 
      spatial registration of the imaging volumes. T1 maps are generated using all four 
      imaging volumes. The signal-polarity in the LGE image is restored using 
      supplementary information from the T1 fit to generate PS-LGE images. The accuracy 
      of the proposed method was assessed with respect to a inversion-recovery 
      spin-echo sequence. In vivo T1 maps and LGE images were acquired with the 
      proposed sequence and quantitatively compared with 2D multislice Modified 
      Look-Locker inversion recovery (MOLLI) T1 maps. Exemplary images in a patient 
      with focal scar were compared with conventional LGE imaging. RESULTS: The 
      deviation of the proposed method and the spin-echo reference was < 11 ms in 
      phantom for T1 times between 250 and 600 ms, regardless of the inversion time 
      selected in the LGE image. There was no significant difference in the in vivo T1 
      times of the proposed sequence and the 2D MOLLI technique (myocardium: 292 +/- 75 
      ms versus 310 +/- 49 ms, blood-pools: 191 +/- 75 ms versus 182.0 +/- 33). The LGE 
      images showed proper nulling of the healthy myocardium in all subjects and clear 
      depiction of scar in the patient. CONCLUSION: The proposed sequence enables 
      simultaneous acquisition of 3D PS-LGE images and spatially registered 3D T1 maps 
      in a single scan.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Weingartner, Sebastian
AU  - Weingartner S
AD  - Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical 
      School, Boston, Massachusetts, USA.
AD  - Computer Assisted Clinical Medicine, University Medical Center Mannheim, 
      Heidelberg University, Mannheim, Germany.
FAU - Akcakaya, Mehmet
AU  - Akcakaya M
AD  - Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical 
      School, Boston, Massachusetts, USA.
FAU - Roujol, Sebastien
AU  - Roujol S
AD  - Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical 
      School, Boston, Massachusetts, USA.
FAU - Basha, Tamer
AU  - Basha T
AD  - Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical 
      School, Boston, Massachusetts, USA.
FAU - Tschabrunn, Cory
AU  - Tschabrunn C
AD  - Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical 
      School, Boston, Massachusetts, USA.
FAU - Berg, Sophie
AU  - Berg S
AD  - Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical 
      School, Boston, Massachusetts, USA.
FAU - Anter, Elad
AU  - Anter E
AD  - Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical 
      School, Boston, Massachusetts, USA.
FAU - Nezafat, Reza
AU  - Nezafat R
AD  - Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical 
      School, Boston, Massachusetts, USA.
LA  - eng
GR  - R01 EB008743/EB/NIBIB NIH HHS/United States
GR  - R01EB008743-01A2/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20141016
PL  - United States
TA  - Magn Reson Med
JT  - Magnetic resonance in medicine
JID - 8505245
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cardiac Imaging Techniques/*methods
MH  - Cardiomyopathy, Hypertrophic/pathology
MH  - Female
MH  - Gadolinium/administration & dosage/*chemistry
MH  - Heart/anatomy & histology
MH  - Humans
MH  - Imaging, Three-Dimensional/*methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Phantoms, Imaging
MH  - Young Adult
PMC - PMC4400224
MID - NIHMS631539
OTO - NOTNLM
OT  - 3D imaging
OT  - LGE imaging
OT  - compressed sensing
OT  - diffused fibrosis
OT  - myocardial T1 mapping
OT  - phase sensitive imaging
OT  - quantitative cardiac MRI
EDAT- 2014/10/18 06:00
MHDA- 2016/06/21 06:00
PMCR- 2016/10/01
CRDT- 2014/10/18 06:00
PHST- 2014/01/29 00:00 [received]
PHST- 2014/08/29 00:00 [revised]
PHST- 2014/09/20 00:00 [accepted]
PHST- 2014/10/18 06:00 [entrez]
PHST- 2014/10/18 06:00 [pubmed]
PHST- 2016/06/21 06:00 [medline]
PHST- 2016/10/01 00:00 [pmc-release]
AID - 10.1002/mrm.25495 [doi]
PST - ppublish
SO  - Magn Reson Med. 2015 Oct;74(4):1032-41. doi: 10.1002/mrm.25495. Epub 2014 Oct 16.