PMID- 25324403
OWN - NLM
STAT- MEDLINE
DCOM- 20150723
LR  - 20201219
IS  - 2326-6074 (Electronic)
IS  - 2326-6066 (Linking)
VI  - 2
IP  - 12
DP  - 2014 Dec
TI  - Prognostic impact of human leukocyte antigen class I expression and association 
      of platinum resistance with immunologic profiles in epithelial ovarian cancer.
PG  - 1220-9
LID - 10.1158/2326-6066.CIR-14-0101 [doi]
AB  - Epithelial ovarian cancer (EOC) is one of the most deadly carcinomas in females. 
      Immune systems can recognize EOCs; however, a defect of human leukocyte antigen 
      (HLA) class I expression is known to be a major mechanism for escape from immune 
      systems, resulting in poor prognosis. The purpose of this study is to identify 
      novel correlations between immunologic responses and other clinical factors. We 
      investigated the expression of immunologic components in 122 cases of EOCs for 
      which surgical operations were performed between 2001 and 2011. We 
      immunohistochemically stained EOC specimens using an anti-pan HLA class I 
      monoclonal antibody (EMR8-5) and anti-CD3, -CD4, and -CD8 antibodies, and we 
      analyzed correlations between immunologic parameters and clinical factors. In 
      multivariate analysis that used the Cox proportional hazards model, independent 
      prognostic factors for overall survival in advanced EOCs included low expression 
      level of HLA class I [risk ratio (RR), 1.97; 95% confidence interval (CI), 
      1.01-3.83; P = 0.046] and loss of intraepithelial cytotoxic T lymphocyte (CTL) 
      infiltration (RR, 2.11; 95% CI, 1.06-4.20; P = 0.033). Interestingly, almost all 
      platinum-resistant cases showed a significantly low rate of intraepithelial CTL 
      infiltration in the chi(2) test (positive vs. negative: 9.0% vs. 97.7%; P < 0.001). 
      Results from a logistic regression model revealed that low CTL infiltration rate 
      was an independent factor of platinum resistance in multivariate analysis (OR, 
      3.77; 95% CI, 1.08-13.12; P = 0.037). Platinum-resistant EOCs show poor 
      immunologic responses. The immune escape system of EOCs may be one of the 
      mechanisms of platinum resistance.
CI  - (c)2014 American Association for Cancer Research.
FAU - Mariya, Tasuku
AU  - Mariya T
AD  - Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, 
      Japan. Department of Obstetrics and Gynecology, Sapporo Medical University School 
      of Medicine, Sapporo, Japan. mariya.tasuku@sapmed.ac.jp hirohash@sapmed.ac.jp 
      torigoe@sapmed.ac.jp.
FAU - Hirohashi, Yoshihiko
AU  - Hirohashi Y
AD  - Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, 
      Japan. mariya.tasuku@sapmed.ac.jp hirohash@sapmed.ac.jp torigoe@sapmed.ac.jp.
FAU - Torigoe, Toshihiko
AU  - Torigoe T
AD  - Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, 
      Japan. mariya.tasuku@sapmed.ac.jp hirohash@sapmed.ac.jp torigoe@sapmed.ac.jp.
FAU - Asano, Takuya
AU  - Asano T
AD  - Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, 
      Japan. Department of Obstetrics and Gynecology, Sapporo Medical University School 
      of Medicine, Sapporo, Japan.
FAU - Kuroda, Takafumi
AU  - Kuroda T
AD  - Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, 
      Japan. Department of Obstetrics and Gynecology, Sapporo Medical University School 
      of Medicine, Sapporo, Japan.
FAU - Yasuda, Kazuyo
AU  - Yasuda K
AD  - Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, 
      Japan.
FAU - Mizuuchi, Masahito
AU  - Mizuuchi M
AD  - Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, 
      Japan. Department of Obstetrics and Gynecology, Sapporo Medical University School 
      of Medicine, Sapporo, Japan.
FAU - Sonoda, Tomoko
AU  - Sonoda T
AD  - Department of Public Health, Sapporo Medical University School of Medicine, 
      Sapporo, Japan.
FAU - Saito, Tsuyoshi
AU  - Saito T
AD  - Department of Obstetrics and Gynecology, Sapporo Medical University School of 
      Medicine, Sapporo, Japan.
FAU - Sato, Noriyuki
AU  - Sato N
AD  - Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, 
      Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141016
PL  - United States
TA  - Cancer Immunol Res
JT  - Cancer immunology research
JID - 101614637
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 49DFR088MY (Platinum)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Agents/*pharmacology/therapeutic use
MH  - Carcinoma, Ovarian Epithelial
MH  - Drug Resistance, Neoplasm/*genetics
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Histocompatibility Antigens Class I/*genetics/*immunology
MH  - Humans
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Neoplasm Staging
MH  - Neoplasms, Glandular and Epithelial/drug 
      therapy/*genetics/*immunology/mortality/pathology
MH  - Ovarian Neoplasms/drug therapy/*genetics/*immunology/mortality/pathology
MH  - Platinum/*pharmacology/therapeutic use
MH  - Prognosis
MH  - Risk Factors
EDAT- 2014/10/18 06:00
MHDA- 2015/07/24 06:00
CRDT- 2014/10/18 06:00
PHST- 2014/10/18 06:00 [entrez]
PHST- 2014/10/18 06:00 [pubmed]
PHST- 2015/07/24 06:00 [medline]
AID - 2326-6066.CIR-14-0101 [pii]
AID - 10.1158/2326-6066.CIR-14-0101 [doi]
PST - ppublish
SO  - Cancer Immunol Res. 2014 Dec;2(12):1220-9. doi: 10.1158/2326-6066.CIR-14-0101. 
      Epub 2014 Oct 16.