PMID- 25324951
OWN - NLM
STAT- MEDLINE
DCOM- 20150610
LR  - 20211021
IS  - 2005-6745 (Electronic)
IS  - 2005-6737 (Print)
IS  - 2005-6737 (Linking)
VI  - 55
IP  - 10
DP  - 2014 Oct
TI  - Role of urinary levels of endothelin-1, monocyte chemotactic peptide-1, and 
      N-acetyl glucosaminidase in predicting the severity of obstruction in 
      hydronephrotic neonates.
PG  - 670-6
LID - 10.4111/kju.2014.55.10.670 [doi]
AB  - PURPOSE: Antenatal hydronephrosis (AH) is found in 0.5%-1% of neonates. The aim 
      of the study was to assess the urinary concentrations of 3 biomarkers, 
      endothelin-1 (ET-1), monocyte chemotactic peptide-1 (MCP-1), and 
      N-acetyl-glucosaminidase (NAG) in severely hydronephrotic neonates. MATERIALS AND 
      METHODS: Neonates with a history of prenatal hydronephrosis were enrolled in the 
      prospective study in 2 groups. Group 1 included neonates with severe forms of 
      obstruction requiring surgical intervention and group 2 included neonates with 
      milder forms of obstruction without any functional impairment. Fresh voided 
      urinary levels of ET-1, MCP-1, and NAG were measured and their ratios to urinary 
      Cr were calculated. RESULTS: Fourty-two neonates were enrolled into the 2 groups: 
      group 1, 24 patients (21 male, 3 female); group 2, 18 neonates (16 male, 2 
      female). There were no statistically significant differences between urinary 
      ET-1, NAG, MCP-1 values, and ET-1/Cr and NAG/Cr ratios in groups 1 and 2. The 
      urinary MCP-1/Cr ratio was significantly higher in group 1 than in group 2. For 
      comparison of groups 1 and 2, the cut-off values were measured as 0.5709 ng/mg 
      (sensitivity, 75%; specificity, 67%; positive predictive value [PPV], 71%; 
      negative predictive value [NPV], 71%), 0.927 ng/mg (sensitivity, 77%; 
      specificity, 72%; PPV, 77%; NPV, 72%), and 1.1913 IU/mg (sensitivity, 62%; 
      specificity, 67%; PPV, 68%; NPV, 60%) for ET-1/Cr, MCP-1/Cr, and NAG/Cr ratios, 
      respectively. CONCLUSIONS: The urinary MCP-1/Cr ratio is significantly elevated 
      in neonates with severe obstruction requiring surgical intervention. Based upon 
      these results, urinary MCP-1/Cr may be useful in identification of severe 
      obstructive hydronephrosis in neonates.
FAU - Mohammadjafari, Hamid
AU  - Mohammadjafari H
AD  - Antimicrobial Resistant Nosocomial Infection Research Center, Mazandaran 
      University of Medical Sciences, Sari, Iran.
FAU - Rafiei, Alireza
AU  - Rafiei A
AD  - Molecular and Cell Biology Research Center, Hemoglubinopathy Institute, Faculty 
      of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
FAU - Mousavi, Seyed Abdollah
AU  - Mousavi SA
AD  - Antimicrobial Resistant Nosocomial Infection Research Center, Mazandaran 
      University of Medical Sciences, Sari, Iran.
FAU - Alaee, Abdulrasool
AU  - Alaee A
AD  - Department of Radiology, Faculty of Medicine, Mazandaran University of Medical 
      Sciences, Sari, Iran.
FAU - Yeganeh, Yalda
AU  - Yeganeh Y
AD  - Department of Radiology, Faculty of Medicine, Mazandaran University of Medical 
      Sciences, Sari, Iran.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20141010
PL  - Korea (South)
TA  - Korean J Urol
JT  - Korean journal of urology
JID - 101499376
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Endothelin-1)
RN  - EC 3.2.1.52 (Acetylglucosaminidase)
SB  - IM
MH  - Acetylglucosaminidase/*urine
MH  - Biomarkers/urine
MH  - Chemokine CCL2/*urine
MH  - Endothelin-1/*urine
MH  - Female
MH  - Humans
MH  - Hydronephrosis/*congenital/diagnostic imaging/etiology/surgery
MH  - Infant, Newborn
MH  - Male
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Sensitivity and Specificity
MH  - Ultrasonography
MH  - Ureteral Obstruction/complications/*diagnosis/surgery
PMC - PMC4198767
OTO - NOTNLM
OT  - Acetylglucosaminidase
OT  - Endothelin-1
OT  - Hydronephrosis
OT  - MCP1 protein
OT  - Neonate
COIS- The authors have nothing to disclose.
EDAT- 2014/10/18 06:00
MHDA- 2015/06/11 06:00
PMCR- 2014/10/01
CRDT- 2014/10/18 06:00
PHST- 2014/06/26 00:00 [received]
PHST- 2014/08/14 00:00 [accepted]
PHST- 2014/10/18 06:00 [entrez]
PHST- 2014/10/18 06:00 [pubmed]
PHST- 2015/06/11 06:00 [medline]
PHST- 2014/10/01 00:00 [pmc-release]
AID - 10.4111/kju.2014.55.10.670 [doi]
PST - ppublish
SO  - Korean J Urol. 2014 Oct;55(10):670-6. doi: 10.4111/kju.2014.55.10.670. Epub 2014 
      Oct 10.