PMID- 25325065
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141017
LR  - 20211021
IS  - 2307-8960 (Print)
IS  - 2307-8960 (Electronic)
IS  - 2307-8960 (Linking)
VI  - 2
IP  - 10
DP  - 2014 Oct 16
TI  - HLA antigens in individuals with down syndrome and alopecia areata.
PG  - 541-5
LID - 10.12998/wjcc.v2.i10.541 [doi]
AB  - AIM: To describe human leukocyte antigen (HLA) alleles in individuals with Down 
      syndrome and alopecia areata. METHODS: A cross-sectional study was conducted, 
      which evaluated 109 individuals. Ten with down syndrome (DS) and alopecia areata 
      (AA), ten with DS without AA and ten with AA without DS, and their families. The 
      individuals were matched by gender and age. The following data were computed: 
      gender, age, ethnic group, karyotype, clinical presentation and family history of 
      alopecia areata. Descriptive analysis: measures of central tendency and frequency 
      distribution. Inferential analysis: Fisher's exact test to compare categorical 
      data between the three groups and Kruskal-Wallis ANOVA test for numerical data. 
      RESULTS: Seventy per cent of evaluated individuals in the DS and AA group were 
      male; presented mean age of 18.6 (SD +/- 7.2) years and 70% were Caucasian. We 
      observed involvement of the scalp, with a single lesion in 10% and multiple in 
      90% of subjects. It was observed that there is no significant difference in the 
      frequency distributions of the alleles HLA loci A, B, C, DRB1 and DQB1 of 
      subjects studied. However, according to Fisher's exact test, there is a trend (P 
      = 0.089) of DS group to present higher proportions of HLA-A 36 and HLA-B 15 than 
      the AA group and AA and DS group. CONCLUSION: There was a tendency for the DS 
      group, to present proportion of HLA-A 36 and HLA-B 15 higher than the AA group 
      and group of individuals with AA and DS. However, there was no significant 
      difference in the frequency distribution of the alleles.
FAU - Estefan, Juliany L
AU  - Estefan JL
AD  - Juliany L Estefan, Eliane D Abad, Simone B Saintive, Pediatric Dermatology 
      Service, Martagao Gesteira Pediatric Institute, Federal University of Rio de 
      Janeiro, Rio de Janeiro, RJ 21941-901, Brazil.
FAU - Oliveira, Juliana C
AU  - Oliveira JC
AD  - Juliany L Estefan, Eliane D Abad, Simone B Saintive, Pediatric Dermatology 
      Service, Martagao Gesteira Pediatric Institute, Federal University of Rio de 
      Janeiro, Rio de Janeiro, RJ 21941-901, Brazil.
FAU - Abad, Eliane D
AU  - Abad ED
AD  - Juliany L Estefan, Eliane D Abad, Simone B Saintive, Pediatric Dermatology 
      Service, Martagao Gesteira Pediatric Institute, Federal University of Rio de 
      Janeiro, Rio de Janeiro, RJ 21941-901, Brazil.
FAU - Saintive, Simone B
AU  - Saintive SB
AD  - Juliany L Estefan, Eliane D Abad, Simone B Saintive, Pediatric Dermatology 
      Service, Martagao Gesteira Pediatric Institute, Federal University of Rio de 
      Janeiro, Rio de Janeiro, RJ 21941-901, Brazil.
FAU - Porto, Luis Cristovao Ms
AU  - Porto LC
AD  - Juliany L Estefan, Eliane D Abad, Simone B Saintive, Pediatric Dermatology 
      Service, Martagao Gesteira Pediatric Institute, Federal University of Rio de 
      Janeiro, Rio de Janeiro, RJ 21941-901, Brazil.
FAU - Ribeiro, Marcia
AU  - Ribeiro M
AD  - Juliany L Estefan, Eliane D Abad, Simone B Saintive, Pediatric Dermatology 
      Service, Martagao Gesteira Pediatric Institute, Federal University of Rio de 
      Janeiro, Rio de Janeiro, RJ 21941-901, Brazil.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Clin Cases
JT  - World journal of clinical cases
JID - 101618806
PMC - PMC4198407
OTO - NOTNLM
OT  - Alopecia areata
OT  - Down syndrome
OT  - Genetic
OT  - Human leukocyte antigen antigens
OT  - Immunology
EDAT- 2014/10/18 06:00
MHDA- 2014/10/18 06:01
PMCR- 2014/10/16
CRDT- 2014/10/18 06:00
PHST- 2014/04/02 00:00 [received]
PHST- 2014/06/03 00:00 [revised]
PHST- 2014/08/27 00:00 [accepted]
PHST- 2014/10/18 06:00 [entrez]
PHST- 2014/10/18 06:00 [pubmed]
PHST- 2014/10/18 06:01 [medline]
PHST- 2014/10/16 00:00 [pmc-release]
AID - 10.12998/wjcc.v2.i10.541 [doi]
PST - ppublish
SO  - World J Clin Cases. 2014 Oct 16;2(10):541-5. doi: 10.12998/wjcc.v2.i10.541.