PMID- 25325278
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150401
LR  - 20211021
IS  - 2093-596X (Print)
IS  - 2093-5978 (Electronic)
IS  - 2093-596X (Linking)
VI  - 30
IP  - 1
DP  - 2015 Mar 27
TI  - Celiac Disease in a Predisposed Subject (HLA-DQ2.5) with Coexisting Graves' 
      Disease.
PG  - 105-9
LID - 10.3803/EnM.2015.30.1.105 [doi]
AB  - Celiac disease is an intestinal autoimmune disorder, triggered by ingestion of a 
      gluten-containing diet in genetically susceptible individuals. The genetic 
      predisposition is related to human leukocyte antigen (HLA) class II genes, 
      especially HLA-DQ2-positive patients. The prevalence of celiac disease has been 
      estimated to be ~1% in Europe and the USA, but it is rarer and/or underdiagnosed 
      in Asia. We report a case of celiac disease in a predisposed patient, with a 
      HLA-DQ2 heterodimer, and Graves' disease that was treated successfully with a 
      gluten-free diet. A 47-year-old woman complained of persistent chronic diarrhea 
      and weight loss over a 9 month period. Results of all serological tests and stool 
      exams were negative. However, the patient was found to carry the HLA DQ2 
      heterodimer. Symptoms improved after a gluten-free diet was initiated. The 
      patient has been followed and has suffered no recurrence of symptoms while on the 
      gluten-free diet. An overall diagnosis of celiac disease was made in a 
      genetically predisposed patient (HLA-DQ2 heterodimer) with Graves' disease.
FAU - Hwang, In Kyoung
AU  - Hwang IK
AD  - Department of Endocrinology and Metabolism, Kyung Hee University School of 
      Medicine, Seoul, Korea.
FAU - Kim, Seon Hye
AU  - Kim SH
AD  - Department of Endocrinology and Metabolism, Kyung Hee University School of 
      Medicine, Seoul, Korea.
FAU - Lee, Unjoo
AU  - Lee U
AD  - Department of Endocrinology and Metabolism, Kyung Hee University School of 
      Medicine, Seoul, Korea.
FAU - Chin, Sang Ouk
AU  - Chin SO
AD  - Department of Endocrinology and Metabolism, Kyung Hee University School of 
      Medicine, Seoul, Korea.
FAU - Rhee, Sang Youl
AU  - Rhee SY
AD  - Department of Endocrinology and Metabolism, Kyung Hee University School of 
      Medicine, Seoul, Korea.
FAU - Oh, Seungjoon
AU  - Oh S
AD  - Department of Endocrinology and Metabolism, Kyung Hee University School of 
      Medicine, Seoul, Korea.
FAU - Woo, Jeong Taek
AU  - Woo JT
AD  - Department of Endocrinology and Metabolism, Kyung Hee University School of 
      Medicine, Seoul, Korea.
FAU - Kim, Sung Woon
AU  - Kim SW
AD  - Department of Endocrinology and Metabolism, Kyung Hee University School of 
      Medicine, Seoul, Korea.
FAU - Kim, Young Seol
AU  - Kim YS
AD  - Department of Endocrinology and Metabolism, Kyung Hee University School of 
      Medicine, Seoul, Korea.
FAU - Chon, Suk
AU  - Chon S
AD  - Department of Endocrinology and Metabolism, Kyung Hee University School of 
      Medicine, Seoul, Korea. imdrjs@khu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20140718
PL  - Korea (South)
TA  - Endocrinol Metab (Seoul)
JT  - Endocrinology and metabolism (Seoul, Korea)
JID - 101554139
PMC - PMC4384671
OTO - NOTNLM
OT  - Celiac disease
OT  - Graves' disease
OT  - HLA-DQ2
COIS- CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2014/10/18 06:00
MHDA- 2014/10/18 06:01
PMCR- 2015/03/01
CRDT- 2014/10/18 06:00
PHST- 2014/03/12 00:00 [received]
PHST- 2014/06/21 00:00 [revised]
PHST- 2014/06/24 00:00 [accepted]
PHST- 2014/10/18 06:00 [entrez]
PHST- 2014/10/18 06:00 [pubmed]
PHST- 2014/10/18 06:01 [medline]
PHST- 2015/03/01 00:00 [pmc-release]
AID - 29.e44 [pii]
AID - 10.3803/EnM.2015.30.1.105 [doi]
PST - ppublish
SO  - Endocrinol Metab (Seoul). 2015 Mar 27;30(1):105-9. doi: 
      10.3803/EnM.2015.30.1.105. Epub 2014 Jul 18.