PMID- 25325281 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20150721 LR - 20220408 IS - 2093-596X (Print) IS - 2093-5978 (Electronic) IS - 2093-596X (Linking) VI - 30 IP - 2 DP - 2015 Jun TI - Comparison of Serum Adipocytokine Levels according to Metabolic Health and Obesity Status. PG - 185-94 LID - 10.3803/EnM.2015.30.2.185 [doi] AB - BACKGROUND: Metabolic health is an emerging concept that is highly correlated with various metabolic complications, and adipocytokines have been causally linked to a wide range of metabolic diseases. Thus, this study compared serum adipocytokine levels according to metabolic health and obesity status. METHODS: Four hundred and fifty-six nondiabetic subjects (mean age, 40.5 years) were categorized into four groups according to metabolic health and obesity status: metabolically healthy nonobese (MHNO), metabolically healthy obese (MHO), metabolically unhealthy nonobese (MUHNO), and metabolically unhealthy obese (MUHO). Being metabolically healthy was defined as the presence of fewer than two of the following five metabolic abnormalities: high blood pressure, high fasting blood glucose, high triglyceride, low high density lipoprotein cholesterol, and being in the highest decile of the homeostatic model assessment of insulin resistance index. Obesity status was assessed using body mass index (BMI), with obesity defined as a BMI higher than 25 kg/m(2). Levels of serum interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor alpha (TNF-alpha), and adipocyte fatty acid binding protein (A-FABP) were also evaluated. RESULTS: Of the 456 subjects, 247 (54.2%) were in the MHNO group, 66 (14.5%) were in the MHO group, 66 (14.5%) were in the MUHNO group, and 77 (16.9%) were in the MUHO group. There were no significant differences in IL-6 or MCP-1 levels among the groups, but levels of TNF-alpha and A-FABP were significantly higher in the MUHNO group compared to the MHNO group. CONCLUSION: High TNF-alpha and A-FABP levels are significantly associated with metabolically unhealthiness in nonobese Korean individuals. FAU - Lee, Tae Hoon AU - Lee TH AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Jeon, Won Seon AU - Jeon WS AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Han, Ki Joong AU - Han KJ AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Lee, Shin Yeoung AU - Lee SY AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Kim, Nam Hee AU - Kim NH AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Chae, Hyun Beom AU - Chae HB AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Jang, Choel Min AU - Jang CM AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Yoo, Kyung Mo AU - Yoo KM AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Park, Hae Jung AU - Park HJ AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Lee, Min Kyung AU - Lee MK AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Park, Se Eun AU - Park SE AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Oh, Hyung Geun AU - Oh HG AD - Department of Neurology, Soonchunhyang University College of Medicine, Cheonan, Korea. FAU - Park, Cheol Young AU - Park CY AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Lee, Won Young AU - Lee WY AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Oh, Ki Won AU - Oh KW AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Park, Sung Woo AU - Park SW AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Rhee, Eun Jung AU - Rhee EJ AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. hongsiri@hanmail.net. LA - eng PT - Journal Article DEP - 20140929 PL - Korea (South) TA - Endocrinol Metab (Seoul) JT - Endocrinology and metabolism (Seoul, Korea) JID - 101554139 CIN - Endocrinol Metab (Seoul). 2015 Sep;30(3):414-5. PMID: 26435138 PMC - PMC4508263 OTO - NOTNLM OT - Adipocytokine OT - Metabolic health OT - Obesity COIS- CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported. EDAT- 2014/10/18 06:00 MHDA- 2014/10/18 06:01 PMCR- 2015/06/01 CRDT- 2014/10/18 06:00 PHST- 2014/06/23 00:00 [received] PHST- 2014/08/03 00:00 [revised] PHST- 2014/08/05 00:00 [accepted] PHST- 2014/10/18 06:00 [entrez] PHST- 2014/10/18 06:00 [pubmed] PHST- 2014/10/18 06:01 [medline] PHST- 2015/06/01 00:00 [pmc-release] AID - 29.e48 [pii] AID - 10.3803/EnM.2015.30.2.185 [doi] PST - ppublish SO - Endocrinol Metab (Seoul). 2015 Jun;30(2):185-94. doi: 10.3803/EnM.2015.30.2.185. Epub 2014 Sep 29.