PMID- 25325797
OWN - NLM
STAT- MEDLINE
DCOM- 20151007
LR  - 20220410
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 99
IP  - 12
DP  - 2014 Dec
TI  - Circulating angiopoietin-like protein 8 is independently associated with fasting 
      plasma glucose and type 2 diabetes mellitus.
PG  - E2510-7
LID - 10.1210/jc.2013-4349 [doi]
AB  - OBJECTIVE: Angiopoietin-like protein 8 (Angptl8) has recently been introduced as 
      a novel adipokine/hepatokine that promotes pancreatic beta-cell proliferation and 
      improves glucose tolerance in mouse models of insulin resistance. However, 
      regulation of Angptl8 in human type 2 diabetes mellitus (T2DM) and renal 
      dysfunction has not been determined. RESEARCH DESIGN AND METHODS: Serum Angptl8 
      levels were quantified by ELISA in 62 patients with T2DM as compared with 58 
      nondiabetic subjects in vivo. Within both groups, about half of the patients were 
      on chronic hemodialysis or had an estimated glomerular filtration rate above 50 
      mL/min/1.73 m(2). Furthermore, we investigated the effect of insulin and 
      differentiation on Angptl8 mRNA expression in 3T3-L1 adipocytes in vitro. 
      RESULTS: Median [interquartile range] serum Angptl8 levels were higher in 
      patients with T2DM (1.19 [0.37] mug/L) as compared with nondiabetic subjects (1.03 
      [0.47] mug/L) (P = .005). Furthermore, the adipokine/hepatokine was significantly 
      higher in women (1.21 [0.47] mug/L) as compared with men (1.05 [0.44] mug/L]) (P = 
      .013). In multivariate analysis, fasting glucose and T2DM but not renal function 
      remained independent and positive predictors of circulating Angptl8 even after 
      adjustment for markers of obesity, lipid status, and inflammation (P < .05). 
      Furthermore, Angptl8 mRNA expression was induced by insulin and during 
      adipogenesis in 3T3-L1 adipocytes in vitro. CONCLUSIONS: Circulating Angptl8 is 
      positively and independently associated with T2DM and fasting glucose in vivo. 
      Furthermore, Angptl8 mRNA expression is induced by insulin and during 
      adipogenesis in 3T3-L1 adipocytes in vitro.
FAU - Ebert, T
AU  - Ebert T
AD  - Department of Endocrinology and Nephrology (T.E., S.K., A.H., A.B., U.L., M.B., 
      M.S., A.T., M.F.) and Institute of Laboratory Medicine (J.K.), University of 
      Leipzig, and Integrated Research and Treatment Center Adiposity Diseases (T.E., 
      S.K., U.L., A.T., M.F.), Leipzig University Medical Center, 04103 Leipzig, 
      Germany.
FAU - Kralisch, S
AU  - Kralisch S
FAU - Hoffmann, A
AU  - Hoffmann A
FAU - Bachmann, A
AU  - Bachmann A
FAU - Lossner, U
AU  - Lossner U
FAU - Kratzsch, J
AU  - Kratzsch J
FAU - Bluher, M
AU  - Bluher M
FAU - Stumvoll, M
AU  - Stumvoll M
FAU - Tonjes, A
AU  - Tonjes A
FAU - Fasshauer, M
AU  - Fasshauer M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (ANGPTL8 protein, human)
RN  - 0 (Angiopoietin-Like Protein 8)
RN  - 0 (Angiopoietin-like Proteins)
RN  - 0 (Blood Glucose)
RN  - 0 (Chromans)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Peptide Hormones)
RN  - 0 (RNA, Messenger)
RN  - 0 (Thiazolidinediones)
RN  - I66ZZ0ZN0E (Troglitazone)
SB  - IM
MH  - 3T3-L1 Cells
MH  - Adipocytes/metabolism
MH  - Angiopoietin-Like Protein 8
MH  - Angiopoietin-like Proteins
MH  - Animals
MH  - Blood Glucose/*metabolism
MH  - Cells, Cultured
MH  - Chromans/pharmacology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Diabetic Nephropathies/blood
MH  - Female
MH  - Humans
MH  - Hypoglycemic Agents/pharmacology
MH  - Insulin/pharmacology
MH  - Male
MH  - Mice
MH  - Middle Aged
MH  - Peptide Hormones/biosynthesis/*blood/genetics
MH  - RNA, Messenger/biosynthesis
MH  - Renal Dialysis
MH  - Thiazolidinediones/pharmacology
MH  - Troglitazone
EDAT- 2014/10/18 06:00
MHDA- 2015/10/08 06:00
CRDT- 2014/10/18 06:00
PHST- 2014/10/18 06:00 [entrez]
PHST- 2014/10/18 06:00 [pubmed]
PHST- 2015/10/08 06:00 [medline]
AID - 10.1210/jc.2013-4349 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2014 Dec;99(12):E2510-7. doi: 10.1210/jc.2013-4349.