PMID- 25327309
OWN - NLM
STAT- MEDLINE
DCOM- 20160607
LR  - 20221207
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 7
IP  - 5
DP  - 2015 Sep
TI  - Salivary interleukin-17 and tumor necrosis factor-alpha in relation to periodontitis 
      and glycemic status in type 2 diabetes mellitus.
PG  - 681-8
LID - 10.1111/1753-0407.12228 [doi]
AB  - BACKGROUND: Poorly-controlled glycemic status in type 2 diabetes mellitus (T2DM) 
      is suggested to play a role in the periodontal inflammatory process by 
      aggregating the local cytokine response. Our objectives were to profile salivary 
      interleukin (IL)-17 and tumor necrosis factor (TNF)-alpha levels in subjects with 
      T2DM and to examine their relevance for the periodontal health status and 
      glycemic control levels. METHODS: Unstimulated whole saliva samples, together 
      with full-mouth periodontal recordings (plaque index [PI], bleeding on probing 
      [BOP %], gingival index [GI], probing pocket depth [PPD], and clinical attachment 
      level [CAL]), were collected from 123 subjects with T2DM. Additionally, 
      demographic and general health parameters, including fasting blood glucose, 
      glycated hemoglobin (HbA1c), were collected. Salivary IL-17 and TNF-alpha 
      concentrations were analyzed using the Luminex(R)-xMAP technique. RESULTS: 
      Subjects with poorly-controlled T2DM (HbA1c >/= 7) had elevated serum triglyceride 
      (P < 0.001) concentration as well as elevated scores of BOP % (P = 0.014), PI 
      (P = 0.048), GI (P = 0.033), and CAL (P = 0.003) in comparison to those of 
      well-controlled T2DM (HbA1c < 7). When the subjects with detectable salivary 
      IL-17 were categorized in tertiles, the scores of PPD and BOP%, and salivary 
      TNF-alpha concentrations were significantly elevated in the highest (P = 0.007, 
      P = 0.002 and P < 0.001, respectively) and middle (P = 0.052, P = 0.022, and 
      P = 0.003, respectively) tertiles compared to subjects with non-detectable 
      salivary IL-17. The adjusted association between PPD measurements and salivary 
      IL-17 concentrations was significant (P = 0.008). CONCLUSIONS: Poorly-controlled 
      glycemic status relates to the severity of periodontal disease in T2DM. The 
      association between PPD and IL-17 in saliva, however, is independent from the 
      effect of glycemic status.
CI  - (c) 2014 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley 
      Publishing Asia Pty Ltd.
FAU - Gursoy, Ulvi Kahraman
AU  - Gursoy UK
AD  - Institute of Dentistry, University of Turku, Turku, Finland.
FAU - Yildiz Ciftlikli, Sinem
AU  - Yildiz Ciftlikli S
AD  - Faculty of Dentistry, University of Marmara, Istanbul, Turkey.
FAU - Kononen, Eija
AU  - Kononen E
AD  - Institute of Dentistry, University of Turku, Turku, Finland.
FAU - Gursoy, Mervi
AU  - Gursoy M
AD  - Institute of Dentistry, University of Turku, Turku, Finland.
FAU - Dogan, Basak
AU  - Dogan B
AD  - Faculty of Dentistry, University of Marmara, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141223
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Interleukin-17)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/complications/drug therapy/*metabolism
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Interleukin-17/*analysis
MH  - Male
MH  - Middle Aged
MH  - Periodontitis/complications/*metabolism
MH  - Saliva/*chemistry
MH  - Tumor Necrosis Factor-alpha/*analysis
OTO - NOTNLM
OT  - interleukin-17
OT  - periodontal disease
OT  - saliva
OT  - tumor necrosis factor-alpha
OT  - type 2 diabetes mellitus
OT  - 关键词：白细胞介素-17，牙周病，唾液，肿瘤坏死因子-alpha，2型糖尿病<
EDAT- 2014/10/21 06:00
MHDA- 2016/06/09 06:00
CRDT- 2014/10/21 06:00
PHST- 2014/05/17 00:00 [received]
PHST- 2014/09/09 00:00 [revised]
PHST- 2014/09/24 00:00 [accepted]
PHST- 2014/10/21 06:00 [entrez]
PHST- 2014/10/21 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
AID - 10.1111/1753-0407.12228 [doi]
PST - ppublish
SO  - J Diabetes. 2015 Sep;7(5):681-8. doi: 10.1111/1753-0407.12228. Epub 2014 Dec 23.