PMID- 25327504
OWN - NLM
STAT- MEDLINE
DCOM- 20150831
LR  - 20221207
IS  - 1432-1041 (Electronic)
IS  - 0031-6970 (Linking)
VI  - 71
IP  - 1
DP  - 2015 Jan
TI  - Clinical features of and genetic predisposition to drug-induced Stevens-Johnson 
      syndrome and toxic epidermal necrolysis in a single Korean tertiary institution 
      patients-investigating the relation between the HLA -B*4403 allele and 
      lamotrigine.
PG  - 35-41
LID - 10.1007/s00228-014-1764-0 [doi]
AB  - PURPOSE: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are 
      rare but fatal adverse mucocutaneous reactions to certain drugs. Recent studies 
      suggest that ethnicity and genetic predisposition may play a crucial role in the 
      manifestation of the reaction. In this study, we described the role of human 
      leukocyte antigen (HLA)-B alleles in the development of clinical characteristics 
      and treatment outcomes of SJS/TEN in a single Korean tertiary hospital. METHODS: 
      We retrospectively reviewed the medical records (from March 1, 2010 to February 
      28, 2014) of 30 patients diagnosed with SJS and/or TEN. RESULTS: The main 
      causative drugs were anticonvulsants (26.7 %) and allopurinol (26.7 %), followed 
      by antibiotics (16.7 %), acetazolamide (10.0 %), acetaminophen (10.0 %), and 
      herbal medication (6.7 %). The mean latencies of these drugs were variable. Liver 
      damage was the most common symptom (observed in 63.3 % of the patients). Of the 
      five patients with lamotrigine-induced SJS/TEN, three expressed the HLA-B*4403 
      allele (60.0 %). Of the seven patients with allopurinol-induced SJS/TEN, five 
      expressed the HLA-B*5801 allele (71.4 %). CONCLUSIONS: The major SJS/TEN-inducing 
      drugs were found to be allopurinol and anticonvulsants (such as lamotrigine). We 
      speculated that Korean individuals expressing the HLA-B*4403 allele may be highly 
      susceptible to lamotrigine-induced SJS/TEN.
FAU - Park, Hye Jung
AU  - Park HJ
AD  - Division of Allergy and Immunology, Department of Internal Medicine, Institute of 
      Allergy, Yonsei University College of Medicine, Seoul, South Korea.
FAU - Kim, Sung Ryeol
AU  - Kim SR
FAU - Leem, Dong Woo
AU  - Leem DW
FAU - Moon, Il Joo
AU  - Moon IJ
FAU - Koh, Beom Seok
AU  - Koh BS
FAU - Park, Kyung Hee
AU  - Park KH
FAU - Park, Jung-Won
AU  - Park JW
FAU - Lee, Jae-Hyun
AU  - Lee JH
LA  - eng
PT  - Journal Article
DEP - 20141021
PL  - Germany
TA  - Eur J Clin Pharmacol
JT  - European journal of clinical pharmacology
JID - 1256165
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anticonvulsants)
RN  - 0 (HLA-B Antigens)
RN  - 0 (Triazines)
RN  - 362O9ITL9D (Acetaminophen)
RN  - 63CZ7GJN5I (Allopurinol)
RN  - O3FX965V0I (Acetazolamide)
RN  - U3H27498KS (Lamotrigine)
SB  - IM
MH  - Acetaminophen/adverse effects
MH  - Acetazolamide/adverse effects
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Allopurinol/adverse effects
MH  - Anti-Bacterial Agents/adverse effects
MH  - Anticonvulsants/*adverse effects
MH  - Asian People/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-B Antigens/*genetics
MH  - Humans
MH  - Lamotrigine
MH  - Male
MH  - Middle Aged
MH  - Plants, Medicinal/adverse effects
MH  - Republic of Korea
MH  - Stevens-Johnson Syndrome/etiology/*genetics
MH  - Tertiary Care Centers
MH  - Triazines/*adverse effects
MH  - Young Adult
EDAT- 2014/10/21 06:00
MHDA- 2015/09/01 06:00
CRDT- 2014/10/21 06:00
PHST- 2014/04/16 00:00 [received]
PHST- 2014/09/29 00:00 [accepted]
PHST- 2014/10/21 06:00 [entrez]
PHST- 2014/10/21 06:00 [pubmed]
PHST- 2015/09/01 06:00 [medline]
AID - 10.1007/s00228-014-1764-0 [doi]
PST - ppublish
SO  - Eur J Clin Pharmacol. 2015 Jan;71(1):35-41. doi: 10.1007/s00228-014-1764-0. Epub 
      2014 Oct 21.