PMID- 25327703
OWN - NLM
STAT- MEDLINE
DCOM- 20160222
LR  - 20211021
IS  - 2041-1723 (Electronic)
IS  - 2041-1723 (Linking)
VI  - 5
DP  - 2014 Oct 20
TI  - Genome-wide association study of breast cancer in Latinas identifies novel 
      protective variants on 6q25.
PG  - 5260
LID - 10.1038/ncomms6260 [doi]
LID - 5260
AB  - The genetic contributions to breast cancer development among Latinas are not well 
      understood. Here we carry out a genome-wide association study of breast cancer in 
      Latinas and identify a genome-wide significant risk variant, located 5' of the 
      Estrogen Receptor 1 gene (ESR1; 6q25 region). The minor allele for this variant 
      is strongly protective (rs140068132: odds ratio (OR) 0.60, 95% confidence 
      interval (CI) 0.53-0.67, P=9 x 10(-18)), originates from Indigenous Americans and 
      is uncorrelated with previously reported risk variants at 6q25. The association 
      is stronger for oestrogen receptor-negative disease (OR 0.34, 95% CI 0.21-0.54) 
      than oestrogen receptor-positive disease (OR 0.63, 95% CI 0.49-0.80; P 
      heterogeneity=0.01) and is also associated with mammographic breast density, a 
      strong risk factor for breast cancer (P=0.001). rs140068132 is located within 
      several transcription factor-binding sites and electrophoretic mobility shift 
      assays with MCF-7 nuclear protein demonstrate differential binding of the G/A 
      alleles at this locus. These results highlight the importance of conducting 
      research in diverse populations.
FAU - Fejerman, Laura
AU  - Fejerman L
AD  - Division of General Internal Medicine, Department of Medicine, Institute of Human 
      Genetics, University of California San Fancisco, San Francisco, California 94158, 
      USA.
FAU - Ahmadiyeh, Nasim
AU  - Ahmadiyeh N
AD  - Department of Surgery, University of California San Francisco, San Francisco, 
      California 94122, USA.
FAU - Hu, Donglei
AU  - Hu D
AD  - Division of General Internal Medicine, Department of Medicine, Institute of Human 
      Genetics, University of California San Fancisco, San Francisco, California 94158, 
      USA.
FAU - Huntsman, Scott
AU  - Huntsman S
AD  - Division of General Internal Medicine, Department of Medicine, Institute of Human 
      Genetics, University of California San Fancisco, San Francisco, California 94158, 
      USA.
FAU - Beckman, Kenneth B
AU  - Beckman KB
AD  - University of Minnesota Genomics Center, Minneapolis, Minnesota 55455, USA.
FAU - Caswell, Jennifer L
AU  - Caswell JL
AD  - Division of General Internal Medicine, Department of Medicine, Institute of Human 
      Genetics, University of California San Fancisco, San Francisco, California 94158, 
      USA.
FAU - Tsung, Karen
AU  - Tsung K
AD  - Department of Surgery, University of California San Francisco, San Francisco, 
      California 94122, USA.
FAU - John, Esther M
AU  - John EM
AD  - 1] Cancer Prevention Institute of California, Fremont, California 94538, USA [2] 
      Division of Epidemiology, Department of Health Research and Policy, Stanford 
      Cancer Institute, Stanford University School of Medicine, Palo Alto, California 
      94305, USA.
FAU - Torres-Mejia, Gabriela
AU  - Torres-Mejia G
AD  - National Institute of Public Health, Cuernavaca 62100, Mexico.
FAU - Carvajal-Carmona, Luis
AU  - Carvajal-Carmona L
AD  - 1] Department of Biochemistry and Molecular Medicine, University of California 
      Davis, Davis, California 95616, USA [2] Research Group, Citogenetica Filogenia y 
      Evolucion de Poblaciones, University of Tolima, Ibague 7652000, Colombia.
FAU - Echeverry, Maria Magdalena
AU  - Echeverry MM
AD  - Department of Biochemistry and Molecular Medicine, University of California 
      Davis, Davis, California 95616, USA.
FAU - Tuazon, Anna Marie D
AU  - Tuazon AM
AD  - Department of Biochemistry and Molecular Medicine, University of California 
      Davis, Davis, California 95616, USA.
FAU - Ramirez, Carolina
AU  - Ramirez C
AD  - Research Group, Citogenetica Filogenia y Evolucion de Poblaciones, University of 
      Tolima, Ibague 7652000, Colombia.
CN  - COLUMBUS Consortium
FAU - Gignoux, Christopher R
AU  - Gignoux CR
AD  - Department of Genetics, Stanford University, Palo Alto, California 94305, USA.
FAU - Eng, Celeste
AU  - Eng C
AD  - Division of Pulmonary and Critical Care, Department of Medicine, Institute for 
      Human Genetics, University of California San Francisco, San Francisco, California 
      94158, USA.
FAU - Gonzalez-Burchard, Esteban
AU  - Gonzalez-Burchard E
AD  - Division of Pulmonary and Critical Care, Department of Medicine, Institute for 
      Human Genetics, University of California San Francisco, San Francisco, California 
      94158, USA.
FAU - Henderson, Brian
AU  - Henderson B
AD  - Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck 
      School of Medicine, University of Southern California, Los Angeles, California 
      90033, USA.
FAU - Le Marchand, Loic
AU  - Le Marchand L
AD  - University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA.
FAU - Kooperberg, Charles
AU  - Kooperberg C
AD  - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 
      Seattle, Washington 98109, USA.
FAU - Hou, Lifang
AU  - Hou L
AD  - Department of Preventive Medicine, Robert H. Lurie Comprehensive Cancer Center, 
      Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, 
      USA.
FAU - Agalliu, Ilir
AU  - Agalliu I
AD  - Department of Epidemiology and Population Health, Albert Einstein College of 
      Medicine, Bronx, New York 10461, USA.
FAU - Kraft, Peter
AU  - Kraft P
AD  - Program in Genetic Epidemiology and Statistical Genetics, Department of 
      Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
FAU - Lindstrom, Sara
AU  - Lindstrom S
AD  - Program in Genetic Epidemiology and Statistical Genetics, Department of 
      Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
FAU - Perez-Stable, Eliseo J
AU  - Perez-Stable EJ
AD  - Division of General Internal Medicine, Department of Medicine, Institute of Human 
      Genetics, University of California San Fancisco, San Francisco, California 94158, 
      USA.
FAU - Haiman, Christopher A
AU  - Haiman CA
AD  - Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck 
      School of Medicine, University of Southern California, Los Angeles, California 
      90033, USA.
FAU - Ziv, Elad
AU  - Ziv E
AD  - Division of General Internal Medicine, Department of Medicine, Institute of Human 
      Genetics, University of California San Fancisco, San Francisco, California 94158, 
      USA.
LA  - eng
GR  - HHSN268201100001I/HL/NHLBI NIH HHS/United States
GR  - UM1 CA164920/CA/NCI NIH HHS/United States
GR  - HHSN268201100046C/HL/NHLBI NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - U01CA86117/CA/NCI NIH HHS/United States
GR  - P30-AG15272/AG/NIA NIH HHS/United States
GR  - HL078885/HL/NHLBI NIH HHS/United States
GR  - R01 CA063446/CA/NCI NIH HHS/United States
GR  - R01 CA132839/CA/NCI NIH HHS/United States
GR  - T32 GM007377/GM/NIGMS NIH HHS/United States
GR  - HHSN268201100003I/HL/NHLBI NIH HHS/United States
GR  - K01 CA160607/CA/NCI NIH HHS/United States
GR  - R25 GM056765/GM/NIGMS NIH HHS/United States
GR  - CA77305/CA/NCI NIH HHS/United States
GR  - UM1 CA164973/CA/NCI NIH HHS/United States
GR  - AI077439/AI/NIAID NIH HHS/United States
GR  - 5UM1CA164973/CA/NCI NIH HHS/United States
GR  - P30 CA015704/CA/NCI NIH HHS/United States
GR  - HHSN268201100004I/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100003C/WH/WHI NIH HHS/United States
GR  - R01 HL078885/HL/NHLBI NIH HHS/United States
GR  - R37 CA54281/CA/NCI NIH HHS/United States
GR  - P30 AG015272/AG/NIA NIH HHS/United States
GR  - U19 AI077439/AI/NIAID NIH HHS/United States
GR  - HHSN271201100004C/AG/NIA NIH HHS/United States
GR  - R01 CA063464/CA/NCI NIH HHS/United States
GR  - U01 CA086117/CA/NCI NIH HHS/United States
GR  - HHSN268201100002C/WH/WHI NIH HHS/United States
GR  - K12 CA138464/CA/NCI NIH HHS/United States
GR  - HHSN268201100002I/HL/NHLBI NIH HHS/United States
GR  - R01 CA63464/CA/NCI NIH HHS/United States
GR  - P30 CA013330/CA/NCI NIH HHS/United States
GR  - R01 HL088133/HL/NHLBI NIH HHS/United States
GR  - R37 CA054281/CA/NCI NIH HHS/United States
GR  - R01 CA120120/CA/NCI NIH HHS/United States
GR  - HHSN268201100001C/WH/WHI NIH HHS/United States
GR  - K24 CA169004/CA/NCI NIH HHS/United States
GR  - HL088133/HL/NHLBI NIH HHS/United States
GR  - HHSN268201100004C/WH/WHI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20141020
PL  - England
TA  - Nat Commun
JT  - Nature communications
JID - 101528555
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Receptors, Estrogen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Biomarkers, Tumor/metabolism
MH  - Breast Neoplasms/*ethnology/*genetics/metabolism
MH  - Case-Control Studies
MH  - Cell Line, Tumor
MH  - Chromosome Mapping
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Genetic Variation
MH  - Genome, Human
MH  - Genome-Wide Association Study
MH  - Genotype
MH  - Humans
MH  - Mammography
MH  - Mexico
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide
MH  - Prospective Studies
MH  - Receptors, Estrogen/metabolism
MH  - Risk Factors
MH  - Young Adult
PMC - PMC4204111
MID - NIHMS628386
FIR - Carvajal-Carmona, Luis
IR  - Carvajal-Carmona L
FIR - Echeverry, Maria Magdalena
IR  - Echeverry MM
FIR - Bohorquez, Mabel Elena
IR  - Bohorquez ME
FIR - Prieto, Rodrigo
IR  - Prieto R
FIR - Criollo, Angel
IR  - Criollo A
FIR - Ramirez, Carolina
IR  - Ramirez C
FIR - Estrada, Ana Patricia
IR  - Estrada AP
FIR - Suares, John Jairo
IR  - Suares JJ
FIR - Mateus, Gilbert
IR  - Mateus G
FIR - Castro, Jorge Mario
IR  - Castro JM
FIR - Sanchez, Yesid
IR  - Sanchez Y
FIR - Murillo, Raul
IR  - Murillo R
FIR - Lucia Serrano, Martha
IR  - Lucia Serrano M
FIR - Sanabria, Carolina
IR  - Sanabria C
FIR - Olaya, Justo German
IR  - Olaya JG
FIR - Bolanos, Fernando
IR  - Bolanos F
FIR - Velez, Alejandro
IR  - Velez A
FIR - Carmona, Jenny Andrea
IR  - Carmona JA
FIR - Velez, Alejandro
IR  - Velez A
FIR - Rodriguez, Nancy Guerrero
IR  - Rodriguez NG
FIR - Seron Sousa, Cristina
IR  - Seron Sousa C
FIR - Mendez, Cesar Eduardo Alvarez
IR  - Mendez CE
FIR - Galviz, Ana Isabel Orduz
IR  - Galviz AI
EDAT- 2014/10/21 06:00
MHDA- 2016/02/24 06:00
PMCR- 2015/03/10
CRDT- 2014/10/21 06:00
PHST- 2014/05/08 00:00 [received]
PHST- 2014/09/12 00:00 [accepted]
PHST- 2014/10/21 06:00 [entrez]
PHST- 2014/10/21 06:00 [pubmed]
PHST- 2016/02/24 06:00 [medline]
PHST- 2015/03/10 00:00 [pmc-release]
AID - ncomms6260 [pii]
AID - 10.1038/ncomms6260 [doi]
PST - epublish
SO  - Nat Commun. 2014 Oct 20;5:5260. doi: 10.1038/ncomms6260.