PMID- 25330859
OWN - NLM
STAT- MEDLINE
DCOM- 20151015
LR  - 20211021
IS  - 1559-1166 (Electronic)
IS  - 0895-8696 (Linking)
VI  - 55
IP  - 3
DP  - 2015 Mar
TI  - Transplanted modified muscle progenitor cells expressing a mixture of 
      neurotrophic factors delay disease onset and enhance survival in the SOD1 mouse 
      model of ALS.
PG  - 788-97
LID - 10.1007/s12031-014-0426-0 [doi]
AB  - Neurotrophic factors (NTFs) are essential growth factor proteins that support the 
      development, survival, and proper function of neurons. We have developed muscle 
      progenitor cell (MPC) populations expressing brain-derived neurotrophic factor 
      (BDNF), glial-derived neurotrophic factor (GDNF), vascular endothelial growth 
      factor (VEGF), or insulin-like growth factor-1 (IGF-1). Transplantation of a 
      mixture of such MPC populations (MPC-MIX) into the hind legs of SOD1 G93A 
      transgenic mice (SOD1 mice), the commonly used model of ALS, delayed the onset of 
      disease symptoms by 30 days and prolonged the average lifespan by 13 days. 
      Treated mice also showed a decrease in the degeneration of neuromuscular junction 
      and an increase in axonal survival. Cellular mechanism assays suggest a 
      synergistic rescue effect of NTFs that involves the AKT and BAD signaling 
      pathways. The results suggest that long-term delivery of a mixture of several 
      NTFs by the transplantation of engineered MPC has a beneficial effect in the ALS 
      mouse model.
FAU - Dadon-Nachum, M
AU  - Dadon-Nachum M
AD  - Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv 
      University, Tel Aviv, Israel.
FAU - Ben-Yaacov, K
AU  - Ben-Yaacov K
FAU - Ben-Zur, T
AU  - Ben-Zur T
FAU - Barhum, Y
AU  - Barhum Y
FAU - Yaffe, D
AU  - Yaffe D
FAU - Perlson, E
AU  - Perlson E
FAU - Offen, D
AU  - Offen D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141021
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (Nerve Growth Factors)
RN  - EC 1.15.1.1 (Sod1 protein, mouse)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.15.1.1 (Superoxide Dismutase-1)
SB  - IM
MH  - Amyotrophic Lateral Sclerosis/genetics/metabolism/*therapy
MH  - Animals
MH  - Female
MH  - Male
MH  - Mice
MH  - Myoblasts/*metabolism/transplantation
MH  - Nerve Growth Factors/genetics/*metabolism
MH  - Neuromuscular Junction/metabolism/pathology
MH  - Superoxide Dismutase/genetics
MH  - Superoxide Dismutase-1
EDAT- 2014/10/22 06:00
MHDA- 2015/10/16 06:00
CRDT- 2014/10/22 06:00
PHST- 2014/07/01 00:00 [received]
PHST- 2014/09/16 00:00 [accepted]
PHST- 2014/10/22 06:00 [entrez]
PHST- 2014/10/22 06:00 [pubmed]
PHST- 2015/10/16 06:00 [medline]
AID - 10.1007/s12031-014-0426-0 [doi]
PST - ppublish
SO  - J Mol Neurosci. 2015 Mar;55(3):788-97. doi: 10.1007/s12031-014-0426-0. Epub 2014 
      Oct 21.