PMID- 25331189
OWN - NLM
STAT- MEDLINE
DCOM- 20161025
LR  - 20161230
IS  - 1097-9867 (Electronic)
IS  - 1083-7450 (Linking)
VI  - 21
IP  - 1
DP  - 2016
TI  - The effect of formulative parameters on the size and physical stability of SLN 
      based on "green" components.
PG  - 98-107
LID - 10.3109/10837450.2014.971376 [doi]
AB  - Cocoa butter (CB) is a largely used excipient in pharmaceutical field. Aim of 
      this work was to set formulative parameters for the preparation of SLN based on 
      "green" lipid matrix for drug delivery as natural, both human and environmental 
      safe systems. Double emulsion technique (w1/o/w2) was selected for SLN 
      preparation. The effect on the dimensional properties of different surfactants 
      (Tween 80 and PEG 40 monostearate) and co-surfactants (PEG400 monostearate, 
      Emulium(R) Kappa2 and Plurol(R)Stearique) at different concentrations was evaluated. 
      Stability tests were performed. SLN dispersions were exsiccated and the effect of 
      the dried process on SLN size was evaluated. The influence of temperature on SLN 
      dimensions was investigated at 37  degrees C. MTT test was performed on raw materials and 
      formulations. The w1/o/w2 is suitable, rapid and economic technique for the 
      preparation of CB SLN. Tween 80-Plurol Stearique combination gives the best 
      results: particles size less than 400 nm and PI of about 0.4 are obtained when PS 
      2% is used. Both raw materials and formulations are safe. The importance to 
      evaluate the effect of different surfactant and/or co-surfactant on the 
      dimensional properties of SLN is evident by selecting substances with preferable 
      safety profiles, and favorable environmental properties to develop stable "green" 
      SLN.
FAU - Soddu, Elena
AU  - Soddu E
AD  - a Dipartimento di Chimica e Farmacia and.
FAU - Rassu, Giovanna
AU  - Rassu G
AD  - a Dipartimento di Chimica e Farmacia and.
FAU - Cossu, Massimo
AU  - Cossu M
AD  - a Dipartimento di Chimica e Farmacia and.
FAU - Giunchedi, Paolo
AU  - Giunchedi P
AD  - a Dipartimento di Chimica e Farmacia and.
FAU - Cerri, Guido
AU  - Cerri G
AD  - b Dipartimento di Scienze della Natura e del Territorio , Universita di Sassari , 
      Sassari , Italy.
FAU - Gavini, Elisabetta
AU  - Gavini E
AD  - a Dipartimento di Chimica e Farmacia and.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141021
PL  - England
TA  - Pharm Dev Technol
JT  - Pharmaceutical development and technology
JID - 9610932
RN  - 0 (Lipids)
RN  - 0 (Polysorbates)
SB  - IM
MH  - Caco-2 Cells
MH  - Cell Survival/drug effects/physiology
MH  - Chemistry, Pharmaceutical
MH  - Dose-Response Relationship, Drug
MH  - Drug Stability
MH  - Green Chemistry Technology/*methods
MH  - Humans
MH  - Lipids/*chemical synthesis/pharmacology
MH  - Nanoparticles/administration & dosage/*chemistry
MH  - *Particle Size
MH  - Polysorbates/chemical synthesis/pharmacology
OTO - NOTNLM
OT  - Cocoa butter
OT  - SLN
OT  - renewal resource
OT  - size
OT  - surfactant/co-surfactant mixture
EDAT- 2014/10/22 06:00
MHDA- 2016/10/26 06:00
CRDT- 2014/10/22 06:00
PHST- 2014/10/22 06:00 [entrez]
PHST- 2014/10/22 06:00 [pubmed]
PHST- 2016/10/26 06:00 [medline]
AID - 10.3109/10837450.2014.971376 [doi]
PST - ppublish
SO  - Pharm Dev Technol. 2016;21(1):98-107. doi: 10.3109/10837450.2014.971376. Epub 
      2014 Oct 21.