PMID- 25331225
OWN - NLM
STAT- MEDLINE
DCOM- 20151124
LR  - 20211021
IS  - 2325-9574 (Print)
IS  - 2325-9582 (Electronic)
IS  - 2325-9574 (Linking)
VI  - 14
IP  - 5
DP  - 2015 Sep-Oct
TI  - Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome 
      (IRIS) in HIV-Infected Patients: A Literature Review.
PG  - 402-7
LID - 10.1177/2325957414555225 [doi]
AB  - INTRODUCTION: After the onset of highly active antiretroviral therapy (HAART), 
      some HIV-infected patients present a severe inflammation in response to a latent 
      or a previously treated opportunistic pathogen termed immune reconstitution 
      inflammatory syndrome (IRIS). Few reports of tegumentary and visceral 
      leishmaniasis have been described in association with IRIS. METHODS: A systematic 
      literature review of IRIS in association with leishmaniasis identified 34 
      reported cases. RESULTS AND DISCUSSION: The majority of these occurred in males 4 
      months following the onset of HAART. The mean CD4 count before HAART was 94 +/- 77 
      cells/mm(3) increasing to 5 times the initial value between the onset of HAART and 
      IRIS presentation. Visceral leishmaniasis and post-kala-azar dermal leishmaniasis 
      were the most commonly reported clinical manifestations, followed by tegumentary 
      leishmaniasis and uveitis. CONCLUSIONS: Commonly found characteristics included 
      cutaneous involvement, regardless of Leishmania species; appearance of lesions 
      unrelated to time of probable Leishmania infection; rapid recovery of CD4 count 
      following HAART; and rapid progression.
CI  - (c) The Author(s) 2014.
FAU - Badaro, Roberto
AU  - Badaro R
AD  - Universidade Federal da Bahia, Complexo Hospitalar Prof Edgard Santos, Unidade 
      docente de Infectologia, Salvador, BA, Brazil rbadaro884@gmail.com.
FAU - Goncalves, Larissa O
AU  - Goncalves LO
AD  - Universidade Federal da Bahia, Complexo Hospitalar Prof Edgard Santos, Unidade 
      docente de Infectologia, Salvador, BA, Brazil.
FAU - Gois, Luana L
AU  - Gois LL
AD  - Fundacao Oswaldo Cruz, Centro de Pesquisa Goncalo Moniz, Laboratorio Avancado de 
      Saude Publica, Salvador, BA, Brazil Escola Bahiana de Medicina e Saude Publica, 
      Faculdade de Medicina, Salvador, BA, Brazil.
FAU - Maia, Zuinara Pereira Gusmao
AU  - Maia ZP
AD  - Universidade Federal da Bahia, Complexo Hospitalar Prof Edgard Santos, Unidade 
      docente de Infectologia, Salvador, BA, Brazil.
FAU - Benson, Constance
AU  - Benson C
AD  - University of California San Diego, Division of Infectious Diseases, La Jolla, 
      CA, USA.
FAU - Grassi, Maria Fernanda Rios
AU  - Grassi MF
AD  - Fundacao Oswaldo Cruz, Centro de Pesquisa Goncalo Moniz, Laboratorio Avancado de 
      Saude Publica, Salvador, BA, Brazil Escola Bahiana de Medicina e Saude Publica, 
      Faculdade de Medicina, Salvador, BA, Brazil.
LA  - eng
GR  - P30 AI036214/AI/NIAID NIH HHS/United States
GR  - P30AI036214/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20141020
PL  - United States
TA  - J Int Assoc Provid AIDS Care
JT  - Journal of the International Association of Providers of AIDS Care
JID - 101603896
SB  - IM
MH  - AIDS-Related Opportunistic Infections/immunology/*parasitology/virology
MH  - Adult
MH  - Female
MH  - HIV Infections/immunology/*parasitology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/immunology/*parasitology/virology
MH  - Leishmaniasis/*immunology/virology
MH  - Male
MH  - Middle Aged
PMC - PMC5004440
MID - NIHMS806069
OTO - NOTNLM
OT  - HIV/AIDS
OT  - IRIS
OT  - co-infection HIV/Leishmania
OT  - immune reconstitution inflammatory syndrome
OT  - leishmaniasis
EDAT- 2014/10/22 06:00
MHDA- 2015/12/15 06:00
PMCR- 2016/08/30
CRDT- 2014/10/22 06:00
PHST- 2014/10/22 06:00 [entrez]
PHST- 2014/10/22 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2016/08/30 00:00 [pmc-release]
AID - 2325957414555225 [pii]
AID - 10.1177/2325957414555225 [doi]
PST - ppublish
SO  - J Int Assoc Provid AIDS Care. 2015 Sep-Oct;14(5):402-7. doi: 
      10.1177/2325957414555225. Epub 2014 Oct 20.