PMID- 25332075
OWN - NLM
STAT- MEDLINE
DCOM- 20150519
LR  - 20211021
IS  - 1617-4623 (Electronic)
IS  - 1617-4615 (Print)
IS  - 1617-4623 (Linking)
VI  - 290
IP  - 2
DP  - 2015 Apr
TI  - The role of the retromer complex in aging-related neurodegeneration: a molecular 
      and genomic review.
PG  - 413-27
LID - 10.1007/s00438-014-0939-9 [doi]
AB  - The retromer coat complex is a vital component of the intracellular trafficking 
      mechanism sorting cargo from the endosomes to the trans-Golgi network or to the 
      cell surface. In recent years, genes encoding components of the retromer coat 
      complex and members of the vacuolar protein sorting 10 (Vps10) family of 
      receptors, which play pleiotropic functions in protein trafficking and 
      intracellular/intercellular signaling in neuronal and non-neuronal cells and are 
      primary cargos of the retromer complex, have been implicated as genetic risk 
      factors for sporadic and autosomal dominant forms of several neurodegenerative 
      diseases, including Alzheimer's disease, Parkinson's disease and frontotemporal 
      lobar degeneration. In addition to their functions in protein trafficking, the 
      members of the Vps10 receptor family (sortilin, SorL1, SorCS1, SorCS2, and 
      SorCS3) modulate neurotrophic signaling pathways. Both sortilin and SorCS2 act as 
      cell surface receptors to mediate acute responses to proneurotrophins. In 
      addition, sortilin can modulate the intracellular response to brain-derived 
      neurotrophic factor (BDNF) by direct control of BDNF levels and regulating 
      anterograde trafficking of Trk receptors to the synapse. This review article 
      summarizes the emerging data from this rapidly growing field of intracellular 
      trafficking signaling in the pathogenesis of neurodegeneration.
FAU - Reitz, Christiane
AU  - Reitz C
AD  - The Department of Neurology, The Department of Epidemiology, The Taub Institute 
      for Research on Alzheimer's Disease and the Aging Brain, The Gertrude H. 
      Sergievsky Center, Columbia University, 630 West 168th Street, New York, NY, 
      10032, USA, cr2101@cumc.columbia.edu.
LA  - eng
GR  - K23 AG034550/AG/NIA NIH HHS/United States
GR  - K23AG034550/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20141021
PL  - Germany
TA  - Mol Genet Genomics
JT  - Molecular genetics and genomics : MGG
JID - 101093320
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Vesicular Transport Proteins)
SB  - IM
EIN - Mol Genet Genomics. 2015 Apr;290(2):429. PMID: 25743489
MH  - *Aging
MH  - Animals
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Mutation
MH  - Neurodegenerative Diseases/*metabolism
MH  - Polymorphism, Single Nucleotide
MH  - Protein Transport
MH  - Receptors, Cell Surface/metabolism
MH  - Signal Transduction
MH  - Vesicular Transport Proteins/*physiology
PMC - PMC4363161
MID - NIHMS636762
EDAT- 2014/10/22 06:00
MHDA- 2015/05/20 06:00
PMCR- 2016/04/01
CRDT- 2014/10/22 06:00
PHST- 2014/06/04 00:00 [received]
PHST- 2014/10/10 00:00 [accepted]
PHST- 2014/10/22 06:00 [entrez]
PHST- 2014/10/22 06:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - 10.1007/s00438-014-0939-9 [doi]
PST - ppublish
SO  - Mol Genet Genomics. 2015 Apr;290(2):413-27. doi: 10.1007/s00438-014-0939-9. Epub 
      2014 Oct 21.