PMID- 25332823
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141021
LR  - 20211021
IS  - 2053-3624 (Print)
IS  - 2053-3624 (Electronic)
IS  - 2053-3624 (Linking)
VI  - 1
IP  - 1
DP  - 2014
TI  - Functional, morphological and electrocardiographical abnormalities in patients 
      with apical hypertrophic cardiomyopathy and apical aneurysm: correlation with 
      cardiac MR.
PG  - e000124
LID - 10.1136/openhrt-2014-000124 [doi]
LID - e000124
AB  - OBJECTIVE: The prognosis of apical hypertrophic cardiomyopathy (APH) has been 
      benign, but apical myocardial injury has prognostic importance. We studied 
      functional, morphological and electrocardiographical abnormalities in patients 
      with APH and with apical aneurysm and sought to find parameters that relate to 
      apical myocardial injury. STUDY DESIGN: a multicentre trans-sectional study. 
      PATIENTS: 45 patients with APH and 5 with apical aneurysm diagnosed with 
      transthoracic echocardiography (TTE) in the database of Hamamatsu Circulation 
      Forum. MEASURE: the apical contraction with cine-cardiac MR (CMR), the myocardial 
      fibrotic scar with late gadolinium enhancement (LGE)-CMR, and QRS fragmentation 
      (fQRS) defined when two ECG-leads exhibited RSR's patterns. RESULTS: Cine-CMR 
      revealed 27 patients with normal, 12 with hypokinetic and 11 with dyskinetic 
      apical contraction. TTE misdiagnosed 11 (48%) patients with hypokinetic and 
      dyskinetic contraction as those with normal contraction. Apical LGE was apparent 
      in 10 (83%) and 11 (100%) patients with hypokinetic and dyskinetic contraction, 
      whereas only in 11 patients (41%) with normal contraction (p<0.01). Patients with 
      dyskinetic apical contraction had the lowest left ventricular ejection fraction, 
      the highest prevalence of ventricular tachycardia, and the smallest ST depression 
      and depth of negative T waves. The presence of fQRS was associated with impaired 
      apical contraction and apical LGE (OR=8.32 and 8.61, p<0.05). CONCLUSIONS: CMR is 
      superior to TTE for analysing abnormalities of the apex in patients with APH and 
      with apical aneurysm. The presence of fQRS can be a promising parameter for the 
      early detection of apical myocardial injury.
FAU - Suwa, Kenichiro
AU  - Suwa K
AD  - The Investigator Group , Hamamatsu Circulation Forum ; (Hamamatsu Circulation 
      Forum consists of Enshu Hospital, Hamamatsu University Hospital, Hamamatsu Red 
      Cross Hospital, Kosai General Hospital and Seirei Mikatahara Hospital.).
FAU - Satoh, Hiroshi
AU  - Satoh H
AD  - The Investigator Group , Hamamatsu Circulation Forum ; (Hamamatsu Circulation 
      Forum consists of Enshu Hospital, Hamamatsu University Hospital, Hamamatsu Red 
      Cross Hospital, Kosai General Hospital and Seirei Mikatahara Hospital.) ; 
      Division of Cardiology, Internal Medicine III, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
FAU - Sano, Makoto
AU  - Sano M
AD  - The Investigator Group , Hamamatsu Circulation Forum ; (Hamamatsu Circulation 
      Forum consists of Enshu Hospital, Hamamatsu University Hospital, Hamamatsu Red 
      Cross Hospital, Kosai General Hospital and Seirei Mikatahara Hospital.).
FAU - Nobuhara, Mamoru
AU  - Nobuhara M
AD  - The Investigator Group , Hamamatsu Circulation Forum ; (Hamamatsu Circulation 
      Forum consists of Enshu Hospital, Hamamatsu University Hospital, Hamamatsu Red 
      Cross Hospital, Kosai General Hospital and Seirei Mikatahara Hospital.).
FAU - Saitoh, Takeji
AU  - Saitoh T
AD  - The Investigator Group , Hamamatsu Circulation Forum ; (Hamamatsu Circulation 
      Forum consists of Enshu Hospital, Hamamatsu University Hospital, Hamamatsu Red 
      Cross Hospital, Kosai General Hospital and Seirei Mikatahara Hospital.).
FAU - Saotome, Masao
AU  - Saotome M
AD  - The Investigator Group , Hamamatsu Circulation Forum ; (Hamamatsu Circulation 
      Forum consists of Enshu Hospital, Hamamatsu University Hospital, Hamamatsu Red 
      Cross Hospital, Kosai General Hospital and Seirei Mikatahara Hospital.).
FAU - Urushida, Tsuyoshi
AU  - Urushida T
AD  - The Investigator Group , Hamamatsu Circulation Forum ; (Hamamatsu Circulation 
      Forum consists of Enshu Hospital, Hamamatsu University Hospital, Hamamatsu Red 
      Cross Hospital, Kosai General Hospital and Seirei Mikatahara Hospital.).
FAU - Katoh, Hideki
AU  - Katoh H
AD  - The Investigator Group , Hamamatsu Circulation Forum ; (Hamamatsu Circulation 
      Forum consists of Enshu Hospital, Hamamatsu University Hospital, Hamamatsu Red 
      Cross Hospital, Kosai General Hospital and Seirei Mikatahara Hospital.).
FAU - Tawarahara, Kei
AU  - Tawarahara K
AD  - The Investigator Group , Hamamatsu Circulation Forum ; (Hamamatsu Circulation 
      Forum consists of Enshu Hospital, Hamamatsu University Hospital, Hamamatsu Red 
      Cross Hospital, Kosai General Hospital and Seirei Mikatahara Hospital.).
FAU - Ohtani, Hayato
AU  - Ohtani H
AD  - The Investigator Group , Hamamatsu Circulation Forum ; (Hamamatsu Circulation 
      Forum consists of Enshu Hospital, Hamamatsu University Hospital, Hamamatsu Red 
      Cross Hospital, Kosai General Hospital and Seirei Mikatahara Hospital.).
FAU - Wakabayashi, Yasushi
AU  - Wakabayashi Y
AD  - The Investigator Group , Hamamatsu Circulation Forum ; (Hamamatsu Circulation 
      Forum consists of Enshu Hospital, Hamamatsu University Hospital, Hamamatsu Red 
      Cross Hospital, Kosai General Hospital and Seirei Mikatahara Hospital.).
FAU - Takase, Hiroyuki
AU  - Takase H
AD  - The Investigator Group , Hamamatsu Circulation Forum ; (Hamamatsu Circulation 
      Forum consists of Enshu Hospital, Hamamatsu University Hospital, Hamamatsu Red 
      Cross Hospital, Kosai General Hospital and Seirei Mikatahara Hospital.).
FAU - Terada, Hajime
AU  - Terada H
AD  - The Investigator Group , Hamamatsu Circulation Forum ; (Hamamatsu Circulation 
      Forum consists of Enshu Hospital, Hamamatsu University Hospital, Hamamatsu Red 
      Cross Hospital, Kosai General Hospital and Seirei Mikatahara Hospital.).
FAU - Takehara, Yasuo
AU  - Takehara Y
AD  - Department of Radiology , Hamamatsu University School of Medicine , Hamamatsu , 
      Japan.
FAU - Sakahara, Harumi
AU  - Sakahara H
AD  - Department of Radiology , Hamamatsu University School of Medicine , Hamamatsu , 
      Japan.
FAU - Hayashi, Hideharu
AU  - Hayashi H
AD  - The Investigator Group , Hamamatsu Circulation Forum ; (Hamamatsu Circulation 
      Forum consists of Enshu Hospital, Hamamatsu University Hospital, Hamamatsu Red 
      Cross Hospital, Kosai General Hospital and Seirei Mikatahara Hospital.).
LA  - eng
PT  - Journal Article
DEP - 20140813
PL  - England
TA  - Open Heart
JT  - Open heart
JID - 101631219
PMC - PMC4189224
EDAT- 2014/10/22 06:00
MHDA- 2014/10/22 06:01
PMCR- 2014/08/13
CRDT- 2014/10/22 06:00
PHST- 2014/03/17 00:00 [received]
PHST- 2014/06/25 00:00 [revised]
PHST- 2014/07/15 00:00 [accepted]
PHST- 2014/10/22 06:00 [entrez]
PHST- 2014/10/22 06:00 [pubmed]
PHST- 2014/10/22 06:01 [medline]
PHST- 2014/08/13 00:00 [pmc-release]
AID - openhrt-2014-000124 [pii]
AID - 10.1136/openhrt-2014-000124 [doi]
PST - epublish
SO  - Open Heart. 2014 Aug 13;1(1):e000124. doi: 10.1136/openhrt-2014-000124. 
      eCollection 2014.