PMID- 25333960
OWN - NLM
STAT- MEDLINE
DCOM- 20150626
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 10
DP  - 2014
TI  - Running a marathon induces changes in adipokine levels and in markers of 
      cartilage degradation--novel role for resistin.
PG  - e110481
LID - 10.1371/journal.pone.0110481 [doi]
LID - e110481
AB  - Running a marathon causes strenuous joint loading and increased energy 
      expenditure. Adipokines regulate energy metabolism, but recent studies have 
      indicated that they also exert a role in cartilage degradation in arthritis. Our 
      aim was to investigate the effects of running a marathon on the levels of 
      adipokines and indices of cartilage metabolism. Blood samples were obtained from 
      46 male marathoners before and after a marathon run. We measured levels of matrix 
      metalloproteinase-3 (MMP-3), cartilage oligomeric protein (COMP) and chitinase 
      3-like protein 1 (YKL-40) as biomarkers of cartilage turnover and/or damage and 
      plasma concentrations of adipokines adiponectin, leptin and resistin. Mean 
      marathon time was 3:30:46+/-0:02:46 (h:min:sec). The exertion more than doubled 
      MMP-3 levels and this change correlated negatively with the marathon time 
      (r = -0.448, p = 0.002). YKL-40 levels increased by 56% and the effect on COMP 
      release was variable. Running a marathon increased the levels of resistin and 
      adiponectin, while leptin levels remained unchanged. The marathon-induced changes 
      in resistin levels were positively associated with the changes in MMP-3 
      (r = 0.382, p = 0.009) and YKL-40 (r = 0.588, p<0.001) and the pre-marathon 
      resistin levels correlated positively with the marathon induced change in YKL-40 
      (r = 0.386, p = 0.008). The present results show the impact of running a 
      marathon, and possible load frequency, on cartilage metabolism: the faster the 
      marathon was run, the greater was the increase in MMP-3 levels. Further, the 
      results introduce pro-inflammatory adipocytokine resistin as a novel factor, 
      which enhances during marathon race and associates with markers of cartilage 
      degradation.
FAU - Vuolteenaho, Katriina
AU  - Vuolteenaho K
AD  - The Immunopharmacology Research Group, University of Tampere School of Medicine 
      and Tampere University Hospital, Tampere, Finland.
FAU - Leppanen, Tiina
AU  - Leppanen T
AD  - The Immunopharmacology Research Group, University of Tampere School of Medicine 
      and Tampere University Hospital, Tampere, Finland.
FAU - Kekkonen, Riina
AU  - Kekkonen R
AD  - Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, 
      Finland.
FAU - Korpela, Riitta
AU  - Korpela R
AD  - Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, 
      Finland.
FAU - Moilanen, Eeva
AU  - Moilanen E
AD  - The Immunopharmacology Research Group, University of Tampere School of Medicine 
      and Tampere University Hospital, Tampere, Finland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141021
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Adipokines)
RN  - 0 (Adiponectin)
RN  - 0 (CHI3L1 protein, human)
RN  - 0 (Cartilage Oligomeric Matrix Protein)
RN  - 0 (Chitinase-3-Like Protein 1)
RN  - 0 (Lectins)
RN  - 0 (Leptin)
RN  - 0 (Resistin)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adipokines/*blood
MH  - Adiponectin/blood
MH  - Adult
MH  - Body Mass Index
MH  - Cartilage/*metabolism
MH  - Cartilage Oligomeric Matrix Protein/blood
MH  - Chitinase-3-Like Protein 1
MH  - Humans
MH  - Lectins/blood
MH  - Leptin/blood
MH  - Male
MH  - Matrix Metalloproteinase 3/blood
MH  - Middle Aged
MH  - Resistin/blood
MH  - Running
PMC - PMC4204875
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/10/22 06:00
MHDA- 2015/06/27 06:00
PMCR- 2014/10/21
CRDT- 2014/10/22 06:00
PHST- 2014/06/27 00:00 [received]
PHST- 2014/09/22 00:00 [accepted]
PHST- 2014/10/22 06:00 [entrez]
PHST- 2014/10/22 06:00 [pubmed]
PHST- 2015/06/27 06:00 [medline]
PHST- 2014/10/21 00:00 [pmc-release]
AID - PONE-D-14-28602 [pii]
AID - 10.1371/journal.pone.0110481 [doi]
PST - epublish
SO  - PLoS One. 2014 Oct 21;9(10):e110481. doi: 10.1371/journal.pone.0110481. 
      eCollection 2014.