PMID- 25335327
OWN - NLM
STAT- MEDLINE
DCOM- 20150122
LR  - 20161018
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 34
IP  - 9
DP  - 2014 Sep
TI  - [Treatment of type 2 diabetic peripheral neuropathy patients of qi-yin deficiency 
      complicated phlegm-dampness blocking collaterals syndrome by internal application 
      of qigui mixture and external application of qigui huoxue lotion: a clinical 
      study].
PG  - 1053-8
AB  - OBJECTIVE: To evaluate the efficacy of internal application of Qigui Mixture (QM) 
      and external application of Qigui Huoxue Lotion (QHL) in treating type 2 diabetic 
      peripheral neuropathy (DNP) patients of qi-yin deficiency complicated 
      phlegm-dampness blocking collaterals syndrome (QYD-PDBCS), and to primarily 
      discuss its mechanism. METHODS: Totally 62 DPN patients of QYD-PDBCS were 
      randomly assigned to the treatment group (31 cases) and the control group (31 
      cases). All patients received routine comprehensive therapy. Patients in the 
      control group took Mecobalamine Tablet, 500 microg each time, 3 times per day. 
      Patients in the treatment group additionally took QM, 200 mL per day, twice 
      daily. Besides, they had foot bath in QHL 10 - 15 min every evening for 3 months. 
      The efficacy was assessed by Chinese medical symptom integrals and Toronto 
      clinical scoring system (TCSS) before treatment, 2 and 3 months after treatment. 
      The nerve conduction velocity was determined; the serum levels of total 
      antioxidant capacity (T- AOC), malondialdehyde (MDA), and superoxide dismutase 
      (SOD) were detected 2 and 3 months after treatment. RESULTS: The total effective 
      rates of Chinese medical symptom integrals and TCSS score were obviously higher 
      in the treatment group than in the control group (P < 0.05). The nerve conduction 
      velocity was significantly improved in the treatment group, when compared with 
      before treatment (P < 0.01). There was statistical difference in the nerve 
      conduction velocity difference of right median nerve motor branch, bilateral 
      tibial nerve motor branches, bilateral common peroneal nerve motor branches, 
      bilateral ulnar nerve sensory branches, and left tibial nerve sensory branch (P < 
      0.05). Compared with before treatment, serum levels of T-AOC and SOD 
      significantly increased, and the level of MDA decreased significantly in the 
      treatment group after 2 and 3 months of treatment (P < 0.01). But only the SOD 
      level increased significantly in the control group (P < 0.01). There was no 
      statistical difference in increased T-AOC level between the two groups after 2 
      months of treatment (P > 0.05), but there was statistical difference in increased 
      SOD level and decreased MDA level (P < 0.05). There was statistical difference in 
      increased T-AOC and SOD levels and decreased MDA level between the two groups 
      after 3 months of treatment (P < 0.05). No adverse reaction occurred during the 
      therapeutic course. CONCLUSIONS: The internal application of QM and external 
      application of QHL combined with Mecobalamine in treating DPN was safe and 
      effective, with more significant efficacy than using Mecobalamine alone. Its 
      mechanism might be associated with resistance to oxidative stress.
FAU - Liu, Jie
AU  - Liu J
FAU - Sun, Bing
AU  - Sun B
FAU - Ban, Bo
AU  - Ban B
FAU - Zhang, Mei
AU  - Zhang M
FAU - Sun, Hai-Ling
AU  - Sun HL
FAU - Li, Ping
AU  - Li P
FAU - Li, Yan-Ying
AU  - Li YY
FAU - Zhang, Yan-Hong
AU  - Zhang YH
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Drugs, Chinese Herbal)
RN  - BR1SN1JS2W (mecobalamin)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Adult
MH  - Diabetes Mellitus, Type 2/complications/drug therapy
MH  - Diabetic Neuropathies/*drug therapy
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Qi
MH  - Treatment Outcome
MH  - Vitamin B 12/analogs & derivatives/therapeutic use
MH  - Yin Deficiency/drug therapy
EDAT- 2014/10/23 06:00
MHDA- 2015/01/23 06:00
CRDT- 2014/10/23 06:00
PHST- 2014/10/23 06:00 [entrez]
PHST- 2014/10/23 06:00 [pubmed]
PHST- 2015/01/23 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014 Sep;34(9):1053-8.