PMID- 25335866
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20221207
IS  - 1559-064X (Electronic)
IS  - 1559-0631 (Linking)
VI  - 26
IP  - 2
DP  - 2016 Mar-Apr
TI  - Association of type 2 diabetes mellitus with plasma organochlorine compound 
      concentrations.
PG  - 207-13
LID - 10.1038/jes.2014.69 [doi]
AB  - The increased prevalence of type 2 diabetes mellitus (T2DM) is associated with 
      obesity, age, and sedentary lifestyle, but exposure to some organochlorine (OC) 
      compounds has also been recently implicated. The hypothesis tested is that higher 
      concentrations of bioaccumulative OC compounds are associated with T2DM. Plasma 
      samples were obtained from a cross-section of adult male and female Caucasians 
      and African Americans, either with or without T2DM from two US Air Force medical 
      facilities. A method of extracting OC compounds from human plasma using solid 
      phase extraction was developed, and three OC compounds [p,p'-DDE (DDE), 
      trans-nonachlor, and oxychlordane] were quantified by gas chromatography/mass 
      spectrometry. Multivariable logistic regression modeling indicated that 
      increasing body mass index (BMI) was associated with T2DM in Caucasians but not 
      in African Americans, and African Americans were more likely to have T2DM than 
      Caucasians with decreasing odds ratios as BMI increased. An association between 
      T2DM and increasing plasma DDE (adjusted for age, base, race, and BMI) was 
      observed. Increasing DDE concentrations were associated with T2DM in older 
      individuals and those with lower BMIs. Thus, in this study sample there was a 
      higher risk of T2DM with increasing DDE concentrations in older people of normal 
      weight and relatively lower risk associated with increasing DDE concentrations in 
      those who are overweight or obese.
FAU - Eden, Paul R
AU  - Eden PR
AD  - Center for Environmental Health Sciences, College of Veterinary Medicine, 
      Mississippi State University, Mississippi State, Mississippi, USA.
FAU - Meek, Edward C
AU  - Meek EC
AD  - Center for Environmental Health Sciences, College of Veterinary Medicine, 
      Mississippi State University, Mississippi State, Mississippi, USA.
FAU - Wills, Robert W
AU  - Wills RW
AD  - Center for Environmental Health Sciences, College of Veterinary Medicine, 
      Mississippi State University, Mississippi State, Mississippi, USA.
FAU - Olsen, Eric V
AU  - Olsen EV
AD  - 81st Medical Group, Clinical Research Laboratory, Keesler AFB, Mississippi, USA.
FAU - Crow, J Allen
AU  - Crow JA
AD  - Center for Environmental Health Sciences, College of Veterinary Medicine, 
      Mississippi State University, Mississippi State, Mississippi, USA.
FAU - Chambers, Janice E
AU  - Chambers JE
AD  - Center for Environmental Health Sciences, College of Veterinary Medicine, 
      Mississippi State University, Mississippi State, Mississippi, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20141022
PL  - United States
TA  - J Expo Sci Environ Epidemiol
JT  - Journal of exposure science & environmental epidemiology
JID - 101262796
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Lipids)
SB  - IM
MH  - Adult
MH  - Black or African American
MH  - Aged
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/blood/*etiology
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*adverse effects/blood
MH  - Lipids/blood
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Military Personnel
MH  - Mississippi
MH  - Obesity/complications
MH  - Ohio
MH  - Risk Factors
MH  - White People
EDAT- 2014/10/23 06:00
MHDA- 2016/12/15 06:00
CRDT- 2014/10/23 06:00
PHST- 2014/02/13 00:00 [received]
PHST- 2014/07/30 00:00 [accepted]
PHST- 2014/10/23 06:00 [entrez]
PHST- 2014/10/23 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - jes201469 [pii]
AID - 10.1038/jes.2014.69 [doi]
PST - ppublish
SO  - J Expo Sci Environ Epidemiol. 2016 Mar-Apr;26(2):207-13. doi: 
      10.1038/jes.2014.69. Epub 2014 Oct 22.