PMID- 25336010
OWN - NLM
STAT- MEDLINE
DCOM- 20161012
LR  - 20161230
IS  - 1442-200X (Electronic)
IS  - 1328-8067 (Linking)
VI  - 56
IP  - 5
DP  - 2014 Oct
TI  - Mesenchymal chondrosarcoma diagnosed on FISH for HEY1-NCOA2 fusion gene.
PG  - e55-7
LID - 10.1111/ped.12407 [doi]
AB  - Mesenchymal chondrosarcoma (MC) is an extremely rare subtype of chondrosarcoma 
      that has a small round-cell sarcoma with focal cartilaginous differentiation, 
      often with a pericytomatous vascular pattern. The non-cartilaginous components 
      are usually dominant, and such lesions might be confused with other small 
      round-cell tumors. Recently, a tumor-specific HEY1-NCOA2 fusion gene was 
      identified in MC. Here we report the case of a 9-year-old boy who was diagnosed 
      with MC by detection of HEY1-NCOA2 fusion signals in almost 50% of tumor cells in 
      tissue sections on fluorescence in situ hybridization (FISH). In this way, the 
      tumor was definitively diagnosed as MC. This case suggests that the detection of 
      the HEY1-NCOA2 fusion gene on FISH is of diagnostic value for MC.
CI  - (c) 2014 Japan Pediatric Society.
FAU - Moriya, Kunihiko
AU  - Moriya K
AD  - Department of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, 
      Miyagi.
FAU - Katayama, Saori
AU  - Katayama S
FAU - Onuma, Masaei
AU  - Onuma M
FAU - Rikiishi, Takeshi
AU  - Rikiishi T
FAU - Hosaka, Masami
AU  - Hosaka M
FAU - Watanabe, Mika
AU  - Watanabe M
FAU - Hasegawa, Tadashi
AU  - Hasegawa T
FAU - Sasahara, Yoji
AU  - Sasahara Y
FAU - Kure, Shigeo
AU  - Kure S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Australia
TA  - Pediatr Int
JT  - Pediatrics international : official journal of the Japan Pediatric Society
JID - 100886002
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (HEY1 protein, human)
RN  - 0 (NCOA2 protein, human)
RN  - 0 (Nuclear Receptor Coactivator 2)
SB  - IM
MH  - Basic Helix-Loop-Helix Transcription Factors/*genetics
MH  - Bone Neoplasms/*diagnosis/*genetics
MH  - Cell Cycle Proteins/*genetics
MH  - Child
MH  - Chondrosarcoma, Mesenchymal/*diagnosis/*genetics
MH  - *Gene Fusion
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Male
MH  - Nuclear Receptor Coactivator 2/*genetics
MH  - *Tibia
OTO - NOTNLM
OT  - HEY1-NCOA2 fusion gene
OT  - fluorescence in situ hybridization
OT  - mesenchymal chondrosarcoma
EDAT- 2014/10/23 06:00
MHDA- 2016/10/13 06:00
CRDT- 2014/10/23 06:00
PHST- 2013/08/02 00:00 [received]
PHST- 2014/02/24 00:00 [revised]
PHST- 2014/04/10 00:00 [accepted]
PHST- 2014/10/23 06:00 [entrez]
PHST- 2014/10/23 06:00 [pubmed]
PHST- 2016/10/13 06:00 [medline]
AID - 10.1111/ped.12407 [doi]
PST - ppublish
SO  - Pediatr Int. 2014 Oct;56(5):e55-7. doi: 10.1111/ped.12407.