PMID- 25336239
OWN - NLM
STAT- MEDLINE
DCOM- 20151228
LR  - 20221207
IS  - 1615-6692 (Electronic)
IS  - 0340-9937 (Linking)
VI  - 40 Suppl 2
DP  - 2015 Apr
TI  - HbA1c levels as predictors of ablation outcome in type 2 diabetes mellitus and 
      paroxysmal atrial fibrillation.
PG  - 130-6
LID - 10.1007/s00059-014-4154-6 [doi]
AB  - AIMS: The aim of this study was to evaluate whether the levels of HbA1c could 
      predict the outcome of ablation in patients with type 2 diabetes mellitus (T2DM) 
      and paroxysmal atrial fibrillation (PAF). PATIENTS AND METHODS: The study 
      comprised 149 consecutive patients with T2DM and PAF who underwent their first 
      circumferential pulmonary vein isolation. HbA1c levels were measured before 
      ablation. Cox proportional hazards models were constructed to assess the 
      relationship between HbA1c levels and the recurrence of atrial fibrillation (AF). 
      RESULTS: Of the 149 patients, 60 (40.3 %) developed AF recurrence after a median 
      12-month follow-up. Multivariate Cox regression analysis revealed that left 
      atrium size and HbA1c were independent predictors of recurrent atrial 
      tachyarrhythmia. Receiver operating characteristic analysis demonstrated that an 
      HbA1c cut-off value of >/= 6.9 % predicted recurrence with 55.0 % sensitivity and 
      67.4 % specificity (AUC = 0.634). The success rate of ablation was 69.0 % in 
      patients with an HbA1c value of < 6.9 % compared with 46.8 % in those with an 
      HbA1c value of >/= 6.9 % (log-rank test, p = 0.004). CONCLUSION: High levels of 
      HbA1c were associated with an increased risk of recurrence of atrial 
      tachyarrhythmia in patients with T2DM and PAF undergoing catheter ablation.
FAU - Lu, Z-H
AU  - Lu ZH
AD  - Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, 2 
      Anzhen Road, 100029, Beijing, Chaoyang District, P.R. China.
FAU - Liu, N
AU  - Liu N
FAU - Bai, R
AU  - Bai R
FAU - Yao, Y
AU  - Yao Y
FAU - Li, S-N
AU  - Li SN
FAU - Yu, R-H
AU  - Yu RH
FAU - Sang, C-H
AU  - Sang CH
FAU - Tang, R-B
AU  - Tang RB
FAU - Long, D-Y
AU  - Long DY
FAU - Du, X
AU  - Du X
FAU - Dong, J-Z
AU  - Dong JZ
FAU - Ma, C-S
AU  - Ma CS
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20141023
PL  - Germany
TA  - Herz
JT  - Herz
JID - 7801231
RN  - 0 (Biomarkers)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Atrial Fibrillation/*blood/epidemiology/*surgery
MH  - Biomarkers/blood
MH  - Catheter Ablation/*statistics & numerical data
MH  - China/epidemiology
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/*blood/*epidemiology
MH  - Disease-Free Survival
MH  - Female
MH  - Glycated Hemoglobin/*analysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Treatment Outcome
EDAT- 2014/10/23 06:00
MHDA- 2015/12/29 06:00
CRDT- 2014/10/23 06:00
PHST- 2014/07/08 00:00 [received]
PHST- 2014/09/09 00:00 [accepted]
PHST- 2014/08/18 00:00 [revised]
PHST- 2014/10/23 06:00 [entrez]
PHST- 2014/10/23 06:00 [pubmed]
PHST- 2015/12/29 06:00 [medline]
AID - 10.1007/s00059-014-4154-6 [doi]
PST - ppublish
SO  - Herz. 2015 Apr;40 Suppl 2:130-6. doi: 10.1007/s00059-014-4154-6. Epub 2014 Oct 
      23.