PMID- 25336531
OWN - NLM
STAT- MEDLINE
DCOM- 20150923
LR  - 20151119
IS  - 1943-3654 (Electronic)
IS  - 0020-1324 (Linking)
VI  - 60
IP  - 1
DP  - 2015 Jan
TI  - Estimation of minimal clinically important difference in EQ-5D visual analog 
      scale score after pulmonary rehabilitation in subjects with COPD.
PG  - 88-95
LID - 10.4187/respcare.03272 [doi]
AB  - BACKGROUND: The effect of pulmonary rehabilitation (PR) on the EuroQol Group's 
      5-dimension questionnaire (EQ-5D) in COPD has been poorly investigated. In 
      addition, conflicting results were reported about the visual analog scale 
      component of EQ-5D (EQ-VAS). The purpose of this study was to evaluate the 
      responsiveness of EQ-VAS to PR and its relationship with clinical and functional 
      parameters in subjects with COPD, as well as to define the minimal clinically 
      important difference (MCID) estimate for the EQ-VAS after PR. METHODS: A total of 
      468 in-patients with stable moderate-to-severe COPD, allocated to a 3-wk PR 
      program, were retrospectively evaluated. EQ-VAS was assessed before and after PR, 
      and its relationship with baseline pulmonary function, changes in 6-min walk 
      test, and baseline, and transitional dyspnea index (BDI/TDI) after PR were 
      evaluated. Using an anchor-based approach and receiver operating characteristic 
      curves, the EQ-VAS change cutoff that identified subjects achieving the known 
      MCID for TDI after PR was identified. RESULTS: Four hundred and thirty-nine 
      subjects (94%, mean FEV1 55.3% predicted) completed pre- and post-PR EQ-VAS 
      scores. After PR, EQ-VAS increased from 58 +/- 17 to 72 +/- 15 (DeltaEQ-VAS 14 +/- 12, P < 
      .001). DeltaEQ-VAS was negatively related to baseline FEV1 (r = -0.32, P < .001) and 
      positively to TDI (r = 0.50, P < .001) and 6-min walk distance (r = 0.46, P < 
      .001) changes. Receiver operating characteristic curves identified an EQ-VAS 
      change cutoff of 8 as the best discriminating value to identify the MCID for TDI 
      (0.78 sensitivity and 0.81 specificity; area under curve: 0.845, P < .001). 
      CONCLUSIONS: Our study shows that, in in-patients with stable moderate-to-severe 
      COPD, EQ-VAS is a valid and reliable tool to assess the responsiveness to PR, 
      with an estimated MCID of 8 points. The EQ-VAS can be a practical alternative to 
      more time-consuming measures of health-related quality of life.
CI  - Copyright (c) 2015 by Daedalus Enterprises.
FAU - Zanini, Andrea
AU  - Zanini A
AD  - Division of Pneumology, Istituto di Ricovero e Cura a Carattere Scientifico 
      Rehabilitation Institute of Tradate, Salvatore Maugeri Foundation, Tradate 
      Department of Clinical and Experimental Medicine, University of Insubria, Varese 
      andrea.zanini@fsm.it.
FAU - Aiello, Marina
AU  - Aiello M
AD  - Respiratory Disease and Lung Function Unit, Department of Clinical and 
      Experimental Medicine, University of Parma, Parma, Italy.
FAU - Adamo, Daniela
AU  - Adamo D
AD  - Division of Pneumology, Istituto di Ricovero e Cura a Carattere Scientifico 
      Rehabilitation Institute of Tradate, Salvatore Maugeri Foundation, Tradate.
FAU - Casale, Silvia
AU  - Casale S
AD  - Division of Pneumology, Istituto di Ricovero e Cura a Carattere Scientifico 
      Rehabilitation Institute of Tradate, Salvatore Maugeri Foundation, Tradate.
FAU - Cherubino, Francesca
AU  - Cherubino F
AD  - Division of Pneumology, Istituto di Ricovero e Cura a Carattere Scientifico 
      Rehabilitation Institute of Tradate, Salvatore Maugeri Foundation, Tradate.
FAU - Della Patrona, Sabrina
AU  - Della Patrona S
AD  - Division of Pneumology, Istituto di Ricovero e Cura a Carattere Scientifico 
      Rehabilitation Institute of Tradate, Salvatore Maugeri Foundation, Tradate.
FAU - Raimondi, Eleonora
AU  - Raimondi E
AD  - Division of Pneumology, Istituto di Ricovero e Cura a Carattere Scientifico 
      Rehabilitation Institute of Tradate, Salvatore Maugeri Foundation, Tradate.
FAU - Zampogna, Elisabetta
AU  - Zampogna E
AD  - Division of Pneumology, Istituto di Ricovero e Cura a Carattere Scientifico 
      Rehabilitation Institute of Tradate, Salvatore Maugeri Foundation, Tradate.
FAU - Chetta, Alfredo
AU  - Chetta A
AD  - Respiratory Disease and Lung Function Unit, Department of Clinical and 
      Experimental Medicine, University of Parma, Parma, Italy.
FAU - Spanevello, Antonio
AU  - Spanevello A
AD  - Division of Pneumology, Istituto di Ricovero e Cura a Carattere Scientifico 
      Rehabilitation Institute of Tradate, Salvatore Maugeri Foundation, Tradate 
      Department of Clinical and Experimental Medicine, University of Insubria, Varese.
LA  - eng
PT  - Journal Article
DEP - 20141021
PL  - United States
TA  - Respir Care
JT  - Respiratory care
JID - 7510357
SB  - IM
MH  - Aged
MH  - Area Under Curve
MH  - Directive Counseling
MH  - Dyspnea/etiology
MH  - Exercise Test
MH  - Exercise Therapy
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Compliance
MH  - Patient Education as Topic
MH  - Pulmonary Disease, Chronic 
      Obstructive/complications/*physiopathology/*rehabilitation
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - *Surveys and Questionnaires
MH  - Walking/physiology
OTO - NOTNLM
OT  - COPD
OT  - EuroQol
OT  - VAS
OT  - pulmonary rehabilitation
EDAT- 2014/10/23 06:00
MHDA- 2015/09/24 06:00
CRDT- 2014/10/23 06:00
PHST- 2014/10/23 06:00 [entrez]
PHST- 2014/10/23 06:00 [pubmed]
PHST- 2015/09/24 06:00 [medline]
AID - respcare.03272 [pii]
AID - 10.4187/respcare.03272 [doi]
PST - ppublish
SO  - Respir Care. 2015 Jan;60(1):88-95. doi: 10.4187/respcare.03272. Epub 2014 Oct 21.