PMID- 25337194
OWN - NLM
STAT- MEDLINE
DCOM- 20150702
LR  - 20211021
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 7
IP  - 9
DP  - 2014
TI  - Remodeling of the thoracic aorta after bone marrow cell transplantation.
PG  - 5527-37
AB  - Stem cells are characterized by their ability to differentiate into multiple cell 
      lineages and display the paracrine effect. The aim of this work was to evaluate 
      the effect of therapy with bone marrow cells (BMCs) on blood glucose, lipid 
      metabolism and aortic wall remodeling in mice through the administration of a 
      high fat diet and subsequent BMCs transplantation. C57BL/6 mice were fed a 
      control diet (CO group) or an atherogenic diet (AT group). After 16 weeks, the AT 
      group was divided into four groups: an AT 14 days group and AT 21 days group, 
      that were given an injection of vehicle and sacrificed at 14 and 21 days after, 
      respectively; AT-BMC 14 days group and AT-BMC 21 days group that was given an 
      injection of BMCs and sacrificed at 14 and 21 days after. The CO group was 
      sacrificed along with other groups. The BMCs transplant had reduced blood 
      glucose, triglycerides and total cholesterol. The Qa (1/mm(2)) was quantitatively 
      reduced in AT 14 days group, AT 21 days group and was high in AT-BMC 21 days 
      group. The AT 21 days group exhibited increased tunica media and elastic system 
      fibers. The immunolabeling for alpha-SMA and VEGF showed less immunolabeling in 
      transplanted groups with BMCs. The immunostaining for PCNA seems to be more 
      expressive in the group AT-BMC 21 days group. To conclude, our results support 
      the concept that in mice, the injection of BMCs improve glucose levels, lipid 
      metabolism and remodeling of the aortic wall in animals using atherogenic diet.
FAU - Felix, Alyne
AU  - Felix A
AD  - Laboratory of Ultrastructure and Tissue Biology, Institute of Biology Roberto 
      Alcantara Gomes, State University of Rio de Janeiro Rio de Janeiro, Brazil.
FAU - Monteiro, Nemesis
AU  - Monteiro N
AD  - Laboratory of Ultrastructure and Tissue Biology, Institute of Biology Roberto 
      Alcantara Gomes, State University of Rio de Janeiro Rio de Janeiro, Brazil.
FAU - Rocha, Vinicius Novaes
AU  - Rocha VN
AD  - Laboratory of Ultrastructure and Tissue Biology, Institute of Biology Roberto 
      Alcantara Gomes, State University of Rio de Janeiro Rio de Janeiro, Brazil.
FAU - Oliveira, Genilza
AU  - Oliveira G
AD  - Laboratory of Cell Culture, Institute of Biology Roberto Alcantara Gomes, State 
      University of Rio de Janeiro Rio de Janeiro, Brazil.
FAU - Moraes, Alan Cesar
AU  - Moraes AC
AD  - Laboratory of Ultrastructure and Tissue Biology, Institute of Biology Roberto 
      Alcantara Gomes, State University of Rio de Janeiro Rio de Janeiro, Brazil.
FAU - Andrade, Cherley
AU  - Andrade C
AD  - Laboratory of Ultrastructure and Tissue Biology, Institute of Biology Roberto 
      Alcantara Gomes, State University of Rio de Janeiro Rio de Janeiro, Brazil.
FAU - Nascimento, Ana Lucia
AU  - Nascimento AL
AD  - Laboratory of Ultrastructure and Tissue Biology, Institute of Biology Roberto 
      Alcantara Gomes, State University of Rio de Janeiro Rio de Janeiro, Brazil.
FAU - de Carvalho, Lais
AU  - de Carvalho L
AD  - Laboratory of Cell Culture, Institute of Biology Roberto Alcantara Gomes, State 
      University of Rio de Janeiro Rio de Janeiro, Brazil.
FAU - Thole, Alessandra
AU  - Thole A
AD  - Laboratory of Cell Culture, Institute of Biology Roberto Alcantara Gomes, State 
      University of Rio de Janeiro Rio de Janeiro, Brazil.
FAU - Carvalho, Jorge
AU  - Carvalho J
AD  - Laboratory of Ultrastructure and Tissue Biology, Institute of Biology Roberto 
      Alcantara Gomes, State University of Rio de Janeiro Rio de Janeiro, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140815
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Acta2 protein, mouse)
RN  - 0 (Actins)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Lipids)
RN  - 0 (Proliferating Cell Nuclear Antigen)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (vascular endothelial growth factor A, mouse)
SB  - IM
MH  - Actins/metabolism
MH  - Animals
MH  - Aorta, Thoracic/metabolism/pathology/*physiopathology
MH  - Aortic Diseases/blood/etiology/pathology/physiopathology/*surgery
MH  - Atherosclerosis/blood/etiology/pathology/physiopathology/*surgery
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - *Bone Marrow Transplantation
MH  - Diet, High-Fat
MH  - Disease Models, Animal
MH  - Lipids/blood
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Proliferating Cell Nuclear Antigen/metabolism
MH  - Time Factors
MH  - Vascular Endothelial Growth Factor A/metabolism
MH  - *Vascular Remodeling
PMC - PMC4203165
OTO - NOTNLM
OT  - Bone marrow cells
OT  - aorta remodeling
OT  - atherogenic diet
EDAT- 2014/10/23 06:00
MHDA- 2015/07/03 06:00
PMCR- 2014/08/15
CRDT- 2014/10/23 06:00
PHST- 2014/07/17 00:00 [received]
PHST- 2014/08/23 00:00 [accepted]
PHST- 2014/10/23 06:00 [entrez]
PHST- 2014/10/23 06:00 [pubmed]
PHST- 2015/07/03 06:00 [medline]
PHST- 2014/08/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2014 Aug 15;7(9):5527-37. eCollection 2014.