PMID- 25337265 OWN - NLM STAT- MEDLINE DCOM- 20150702 LR - 20221207 IS - 1936-2625 (Electronic) IS - 1936-2625 (Linking) VI - 7 IP - 9 DP - 2014 TI - Human leukocyte antigen-DRB1*1501 and DQB1*0602 alleles are cervical cancer protective factors among Uighur and Han people in Xinjiang, China. PG - 6165-71 AB - Human papillomavirus (HPV) infection is a major risk factor for cervical cancer. However, only some high risk human papillomavirus (HR-HPV)-infected women progress to cervical cancer, host immunogenetic factors human leukocyte antigen (HLA) may account for viral antigens presenting individually or together in the progression to cervical cancer. This study examined the association between the development of invasive cervical cancer (ICC) and the determinant factors including HLA-DRB1*1501 and DQB1*0602, HR-HPV infection among Chinese Uighur and Han populations. Blood samples, cervical swabs and biopsies were obtained from 287 patients with ICC (192 Uighurs and 95 Hans) and 312 healthy controls (218 Uighurs and 94 Hans). HPV DNA was detected by PCR and HLA-DRB1*1501 and DQB1*0602 alleles were performed using PCR-SSP method. HPV16 infection rates was significantly higher among Uighur and Han with ICC as compared to healthy controls (OR = 58.317; 95% CI: 39.663-85.744; OR = 33.778; 95% CI: 12.581-90.691; P < 0.05 for all). HLA-DRB1*1501 (OR = 0.305; 95% CI: 0.115-0.813; P < 0.05) and HLA-DRB1*1501-DQB1*0602 haplotype frequencies (OR = 0.274; 95% CI: 0.086-0.874; P < 0.05) were significantly reduced in Han ICC. The HLA-DQB1*0602 frequency significantly decreased among Uighur women with ICC (OR = 0.482; 95% CI: 0.325-0.716; P < 0.05). Similar tendencies were observed for DQB1*0602 with HPV16-positive ICC (OR = 0.550; 95% CI: 0.362-0.837; P < 0.05). This study suggests that HLA-DRB1*1501 and DQB1*0602 alleles may influence the immune response to HPV16 infection and decrease the risk of ICC among Uighurs and Hans in Xinjiang, China. FAU - Hu, Jian Ming AU - Hu JM AD - Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine Shihezi 832002, Xinjiang, China ; Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, China. FAU - Sun, Qi AU - Sun Q AD - Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine Shihezi 832002, Xinjiang, China. FAU - Li, Ling AU - Li L AD - Shihezi UniversitySchool of Life Science Xinjiang 832002, China. FAU - Liu, Chun Xia AU - Liu CX AD - Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine Shihezi 832002, Xinjiang, China. FAU - Chen, Yun Zhao AU - Chen YZ AD - Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine Shihezi 832002, Xinjiang, China. FAU - Zou, Hong AU - Zou H AD - Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine Shihezi 832002, Xinjiang, China. FAU - Pang, Li Juan AU - Pang LJ AD - Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine Shihezi 832002, Xinjiang, China. FAU - Zhao, Jin AU - Zhao J AD - Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine Shihezi 832002, Xinjiang, China. FAU - Yang, Lan AU - Yang L AD - Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine Shihezi 832002, Xinjiang, China. FAU - Cao, Yu Wen AU - Cao YW AD - Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine Shihezi 832002, Xinjiang, China. FAU - Cui, Xiao Bin AU - Cui XB AD - Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine Shihezi 832002, Xinjiang, China. FAU - Qi, Yan AU - Qi Y AD - Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine Shihezi 832002, Xinjiang, China. FAU - Liang, Wei Hua AU - Liang WH AD - Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine Shihezi 832002, Xinjiang, China. FAU - Zhang, Wen Jie AU - Zhang WJ AD - Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine Shihezi 832002, Xinjiang, China. FAU - Li, Feng AU - Li F AD - Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine Shihezi 832002, Xinjiang, China ; Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140815 PL - United States TA - Int J Clin Exp Pathol JT - International journal of clinical and experimental pathology JID - 101480565 RN - 0 (DNA, Viral) RN - 0 (HLA-DQ beta-Chains) RN - 0 (HLA-DQB1 antigen) RN - 0 (HLA-DRB1 Chains) RN - 0 (HLA-DRB1*15:01 antigen) SB - IM MH - Adult MH - Aged MH - Asian People/*genetics MH - Case-Control Studies MH - Chi-Square Distribution MH - China/epidemiology MH - DNA, Viral/genetics MH - Female MH - Gene Frequency MH - Genetic Predisposition to Disease MH - HLA-DQ beta-Chains/*genetics MH - HLA-DRB1 Chains/*genetics MH - Haplotypes MH - Human Papillomavirus DNA Tests MH - Human papillomavirus 16/genetics MH - Humans MH - Logistic Models MH - Middle Aged MH - Neoplasm Invasiveness MH - Odds Ratio MH - Papillomavirus Infections/ethnology/*genetics/immunology/virology MH - Phenotype MH - Polymerase Chain Reaction MH - Predictive Value of Tests MH - Protective Factors MH - Risk Factors MH - Uterine Cervical Neoplasms/ethnology/*genetics/immunology/*prevention & control/virology PMC - PMC4203236 OTO - NOTNLM OT - HLA OT - HPV OT - Uighur OT - invasive cervical cancer OT - susceptibility EDAT- 2014/10/23 06:00 MHDA- 2015/07/03 06:00 PMCR- 2014/08/15 CRDT- 2014/10/23 06:00 PHST- 2014/06/25 00:00 [received] PHST- 2014/08/02 00:00 [accepted] PHST- 2014/10/23 06:00 [entrez] PHST- 2014/10/23 06:00 [pubmed] PHST- 2015/07/03 06:00 [medline] PHST- 2014/08/15 00:00 [pmc-release] PST - epublish SO - Int J Clin Exp Pathol. 2014 Aug 15;7(9):6165-71. eCollection 2014.