PMID- 25337329
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141022
LR  - 20201001
IS  - 2008-126X (Print)
IS  - 2228-7442 (Electronic)
IS  - 2008-126X (Linking)
VI  - 4
IP  - 1
DP  - 2013 Winter
TI  - Effects of Repeated Administration of 3,4-methylenedioxymethamphetamine (MDMA) on 
      Avoidance Memory and Cell Density in Rats' Hippocampus.
PG  - 57-63
AB  - INTRODUCTION: MDMA or ecstasy is a derivative of amphetamines used mostly by 
      young people worldwide. Although the acute effects of this drug are known, the 
      effect of chronic administration is not well studied. Therefor the aim of this 
      study was to determine the effects of repeated (long term) administration of MDMA 
      on rats' memory and their hippocampal cell density. METHOD: Young adult male 
      Wistar rats 200 +/- 20 g served as subjects. The rats were randomly distributed 
      into three MDMA treated groups (3x2.5 mg/kg, 3x5 mg/kg, 3x10 mg/kg) and one 
      control-saline group. All animals received MDMA intraperitoneally (3h apart; a 
      challenge) 7th day of every week for consecutive 4 weeks. Animals were trained 
      before and were tested after injections for their memory status using the 
      standards passive avoidance method. Finally, 24hr after the memory test, rats 
      were sacrificed and after tissue operations, the hippocampal astrocytes and 
      neurons were counted. RESULTS: Results showed that the number of neurons in all 
      experimental groups was lower than the control-saline group. The most decreased 
      number of neurons was shown in 5 mg/kg MDMA group compared to control-saline in 
      all the regions of hippocampus. Also we found that repeated administration of 
      MDMA reduced the number of hippocampal astrocytes. DISCUSSION: It is concluded 
      that repeated administration of MDMA can reduce density of neurons and astrocytes 
      and this decrease is not dose dependence.
FAU - Jahanshahi, Mehrdad
AU  - Jahanshahi M
AD  - Neuroscience Research Center, Department of Anatomy, Golestan University of 
      Medical Sciences, Gorgan, Iran.
FAU - Haidari, Kamran
AU  - Haidari K
AD  - Neuroscience Research Center, Department of Anatomy, Golestan University of 
      Medical Sciences, Gorgan, Iran.
FAU - Mahaki-Zadeh, Simin
AU  - Mahaki-Zadeh S
AD  - Neuroscience Research Center, Department of Anatomy, Golestan University of 
      Medical Sciences, Gorgan, Iran.
FAU - Nikmahzar, EmseGol
AU  - Nikmahzar E
AD  - Neuroscience Research Center, Department of Anatomy, Golestan University of 
      Medical Sciences, Gorgan, Iran.
FAU - Babakordi, Fatemeh
AU  - Babakordi F
AD  - Neuroscience Research Center, Department of Anatomy, Golestan University of 
      Medical Sciences, Gorgan, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Basic Clin Neurosci
JT  - Basic and clinical neuroscience
JID - 101575211
PMC - PMC4202557
OTO - NOTNLM
OT  - Astrocytes
OT  - Ecstasy
OT  - Neurons
OT  - Passive Avoidance Memory
EDAT- 2013/01/01 00:00
MHDA- 2013/01/01 00:01
PMCR- 2013/12/01
CRDT- 2014/10/23 06:00
PHST- 2012/10/20 00:00 [received]
PHST- 2012/12/18 00:00 [revised]
PHST- 2013/01/15 00:00 [accepted]
PHST- 2014/10/23 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2013/01/01 00:01 [medline]
PHST- 2013/12/01 00:00 [pmc-release]
AID - BCN-4-057 [pii]
PST - ppublish
SO  - Basic Clin Neurosci. 2013 Winter;4(1):57-63.