PMID- 25337365
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141022
LR  - 20200930
IS  - 2008-126X (Print)
IS  - 2228-7442 (Electronic)
IS  - 2008-126X (Linking)
VI  - 4
IP  - 4
DP  - 2013 Fall
TI  - Ecstasy-induced caspase expression alters following ginger treatment.
PG  - 329-33
AB  - INTRODUCTION: Exposure to 3-4, methylenedioxymethamphetamine (MDMA) leads to cell 
      death. Herein, we studied the protective effects of ginger on MDMA- induced 
      apoptosis. METHODS: 15 Sprague dawley male rats were administrated with 0, 10 
      mg/kg MDMA, or MDMA along with 100mg/kg ginger, IP for 7 days. Brains were 
      removed to study the caspase 3, 8, and 9 expressions in the hippocampus by 
      RT-PCR. Data was analyzed by SPSS 16 software using the one-way ANOVA test. 
      RESULTS: MDMA treatment resulted in a significant increase in caspase 3, 8, and 9 
      as compared to the sham group (p < 0.001). Ginger administration however, 
      appeared to significantly decrease the same (p < 0.001). DISCUSSION: Our findings 
      suggest that ginger consumption may lead to the improvement of MDMA-induced 
      neurotoxicity.
FAU - Asl, Sara Soleimani
AU  - Asl SS
AD  - Research Center for Behavioral Disorders and Substance Abuse, Hamadan University 
      of Medical Sciences, Hamadan, Iran ; Department of Anatomy, School of Medicine, 
      Hamadan University of Medical Sciences, Hamadan, Iran.
FAU - Pourheydar, Bagher
AU  - Pourheydar B
AD  - Neurophysiology Research Center, Urmia University of Medical Sciences, Urmia, 
      Iran ; Department of Anatomy, Faculty of Medicine, Urmia University of Medical 
      Sciences, Urmia, Iran.
FAU - Dabaghian, Fataneh
AU  - Dabaghian F
AD  - Research Institute for Islamic and Complementary Medicine, Tehran University of 
      Medical Sciences, Tehran, Iran.
FAU - Nezhadi, Akram
AU  - Nezhadi A
AD  - Department of Anatomy, AJA University of Medical Sciences, Tehran, Iran.
FAU - Roointan, Amir
AU  - Roointan A
AD  - Research Center for Molecular Medicine, Hamadan University of Medical Sciences, 
      Hamadan, Iran.
FAU - Mehdizadeh, Mehdi
AU  - Mehdizadeh M
AD  - Research Institute for Islamic and Complementary Medicine, Tehran University of 
      Medical Sciences, Tehran, Iran ; Department of Anatomy, Faculty of Medicine, 
      Tehran University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Basic Clin Neurosci
JT  - Basic and clinical neuroscience
JID - 101575211
PMC - PMC4202580
OTO - NOTNLM
OT  - Apoptosis
OT  - Caspase
OT  - Ginger
OT  - MDMA
EDAT- 2014/10/23 06:00
MHDA- 2014/10/23 06:01
PMCR- 2013/09/01
CRDT- 2014/10/23 06:00
PHST- 2013/04/13 00:00 [received]
PHST- 2013/05/03 00:00 [revised]
PHST- 2013/05/29 00:00 [accepted]
PHST- 2014/10/23 06:00 [entrez]
PHST- 2014/10/23 06:00 [pubmed]
PHST- 2014/10/23 06:01 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - BCN-4-329 [pii]
PST - ppublish
SO  - Basic Clin Neurosci. 2013 Fall;4(4):329-33.