PMID- 25337371
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141022
LR  - 20230403
IS  - 2008-126X (Print)
IS  - 2228-7442 (Electronic)
IS  - 2008-126X (Linking)
VI  - 5
IP  - 2
DP  - 2014 Spring
TI  - Effect of Chronic Restraint Stress on HPA Axis Activity and Expression of BDNF 
      and Trkb in the Hippocampus of Pregnant Rats: Possible Contribution in Depression 
      during Pregnancy and Postpartum Period.
PG  - 131-7
AB  - INTRODUCTION: Brain-Derived Neurotrophic Factor (BDNF) and its receptor, TrkB, in 
      the hippocampus are targets for adverse effects of stress paradigms; in addition, 
      BDNF and its receptor play key role in the pathology of brain diseases like 
      depression. In the present study, we evaluated the possible role of hippocampal 
      BDNF in depression during pregnancy. METHODS: To achieve the purpose, repeated 
      restrain stress (1 or 3 hours daily for 7 days) during the last week of pregnancy 
      was used and alteration in the gene expression of hippocampal BDNF and TrkB 
      evaluated by semi-quantitative PCR. RESULTS: The results showed that in stress 
      group the level of ACTH and Corticosterone is increased showing that our model 
      was efficient in inducing psychological stress; we also found that BDNF and TrkB 
      expression are decreased in 3 hours stress group but not in 1 hour stress 
      compared to control group. DISCUSSION: Our results imply that decrease in BDNF 
      and its receptor could contribute in some adverse effects of stress during 
      pregnancy such as elevation of depressive like behavior.
FAU - Maghsoudi, Nader
AU  - Maghsoudi N
AD  - Neurobiology Research Center and Neuroscience Research Centre, Shahid Beheshti 
      University of Medical Sciences, Tehran, Iran.
FAU - Ghasemi, Rasoul
AU  - Ghasemi R
AD  - Neurobiology Research Center and Neuroscience Research Centre, Shahid Beheshti 
      University of Medical Sciences, Tehran, Iran.
FAU - Ghaempanah, Zahra
AU  - Ghaempanah Z
AD  - Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, 
      Tehran, Iran.
FAU - Ardekani, Ali M
AU  - Ardekani AM
AD  - Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, 
      Tehran, Iran.
FAU - Nooshinfar, Elahe
AU  - Nooshinfar E
AD  - Department of Physiology, Faculty of Paramedical Sciences, Shahid Beheshti 
      University of Medical Sciences, Tehran, Iran.
FAU - Tahzibi, Abbas
AU  - Tahzibi A
AD  - Food & Drug Organization, FDO, Tehran university of medical sciences, Tehran, 
      Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Basic Clin Neurosci
JT  - Basic and clinical neuroscience
JID - 101575211
PMC - PMC4202592
OTO - NOTNLM
OT  - ACTH
OT  - BDNF
OT  - Corticosterone
OT  - Depression
OT  - Semi-quantitative RT-PCR
OT  - Stress
EDAT- 2014/10/23 06:00
MHDA- 2014/10/23 06:01
PMCR- 2014/03/01
CRDT- 2014/10/23 06:00
PHST- 2013/02/16 00:00 [received]
PHST- 2013/03/11 00:00 [revised]
PHST- 2013/04/17 00:00 [accepted]
PHST- 2014/10/23 06:00 [entrez]
PHST- 2014/10/23 06:00 [pubmed]
PHST- 2014/10/23 06:01 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - BCN-5-131 [pii]
PST - ppublish
SO  - Basic Clin Neurosci. 2014 Spring;5(2):131-7.