PMID- 25337384
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141022
LR  - 20211021
IS  - 2008-126X (Print)
IS  - 2228-7442 (Electronic)
IS  - 2008-126X (Linking)
VI  - 5
IP  - 3
DP  - 2014 Summer
TI  - Acute Effects of Ecstasy on Memory Are more Extensive than Chronic Effects.
PG  - 225-30
AB  - INTRODUCTION: Exposure to 3, 4- methylenedioxymethamphetamine (MDMA) could lead 
      to serotonergic system toxicity in the brain. This system is responsible for 
      learning and memory functions. Studies show that MDMA causes memory impairment 
      dose-dependently and acutely. The present study was designed to evaluate the 
      chronic and acute effects of MDMD on spatial memory and acquisition of passive 
      avoidance. METHODS: Adult male Wistar rats (200-250 g) were given single or 
      multiple injections of MDMA (10 mg/kg, IP). Using passive avoidance and Morris 
      Water Maze (MWM) tasks, learning and spatial memory functions were assessed. The 
      data were analyzed by SPSS 16 software and one- way analysis of variance (ANOVA) 
      test. RESULTS: Our results showed that there were significant differences in 
      latency to enter the dark compartment (STL) between sham and MDMA- treated 
      groups. Acute group significantly showed more STL in comparison with chronic 
      group. Furthermore, MDMA groups spent more time in dark compartment (TDS) than 
      the sham group. Administration of single dose of MDMA significantly caused an 
      increase in TDS compared with the chronic group. In the MWM, MDMA treatment 
      significantly increased the traveled distance and escaped latency compared to the 
      sham group. Like to passive avoidance task, percentage of time spent in the 
      target quadrant in MDMA- treated animals impaired in MWM compared with sham 
      group. DISCUSSION: These data suggest that MDMA treatment impairs learning and 
      memory functions that are more extensive in acute- treated rats.
FAU - Shariati, Mohamad Bakhtiar Hesam
AU  - Shariati MB
AD  - Research Center for Behavioral Disorders and Substance Abuse, Hamadan University 
      of Medical Sciences, Hamadan, Iran.
FAU - Sohrabi, Maryam
AU  - Sohrabi M
AD  - Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, 
      Hamadan, Iran.
FAU - Shahidi, Siamak
AU  - Shahidi S
AD  - Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, 
      Iran.
FAU - Nikkhah, Ali
AU  - Nikkhah A
AD  - Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, 
      Iran.
FAU - Mirzaei, Fatemeh
AU  - Mirzaei F
AD  - Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, 
      Hamadan, Iran.
FAU - Medizadeh, Mehdi
AU  - Medizadeh M
AD  - Cellular & Molecular Research Center, Faculty of Advanced Technology in Medicne, 
      Department of Anatomical Sciences, Iran University of Medical Sciences, Tehran, 
      Iran.
FAU - Asl, Sara Soleimani
AU  - Asl SS
AD  - Research Center for Behavioral Disorders and Substance Abuse, Hamadan University 
      of Medical Sciences, Hamadan, Iran ; Anatomy Department, School of Medicine, 
      Hamadan University of Medical Sciences, Hamadan, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Basic Clin Neurosci
JT  - Basic and clinical neuroscience
JID - 101575211
PMC - PMC4202547
OTO - NOTNLM
OT  - Ecstasy
OT  - Learning
OT  - Spatial Memory
EDAT- 2014/10/23 06:00
MHDA- 2014/10/23 06:01
PMCR- 2014/06/01
CRDT- 2014/10/23 06:00
PHST- 2013/10/04 00:00 [received]
PHST- 2013/11/25 00:00 [revised]
PHST- 2013/12/13 00:00 [accepted]
PHST- 2014/10/23 06:00 [entrez]
PHST- 2014/10/23 06:00 [pubmed]
PHST- 2014/10/23 06:01 [medline]
PHST- 2014/06/01 00:00 [pmc-release]
AID - BCN-5-225 [pii]
PST - ppublish
SO  - Basic Clin Neurosci. 2014 Summer;5(3):225-30.