PMID- 25337466
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141022
LR  - 20220311
IS  - 2228-5652 (Print)
IS  - 2228-5660 (Electronic)
IS  - 2228-5652 (Linking)
VI  - 4
IP  - 3
DP  - 2014
TI  - Association of CRP gene polymorphism with CRP levels and Coronary Artery Disease 
      in Type 2 Diabetes in Ahvaz, southwest of Iran.
PG  - 133-9
LID - 10.15171/bi.2014.006 [doi]
AB  - INTRODUCTION: We evaluated the association between four polymorphisms in the CRP 
      gene with serum C-reactive protein (CRP) levels, prevalence and severity of 
      coronary artery disease (CAD) in type 2 diabetes mellitus (T2DM) patients. 
      METHODS: We performed coronary angiography for 308 T2DM patients and classified 
      them into two groups: T2DM with CAD and T2DM without CAD. All patients were from 
      Ahvaz, Iran. serum levels of CRP, glucose and lipid profile were measured. 
      Genotyping was performed by PCR/RFLP, and the severity of coronary artery disease 
      was determined by Gensini score. RESULTS: The GG genotype of SNP rs279421 was 
      associated with the increased risk of CAD (OR= 2.38; 95% CI: 1.12- 5.8; p= 0.02) 
      and CA, TT, TA genotypes and A allele of SNP rs3091244 and GA genotypes and A 
      allele of SNP rs3093062 were significantly associated with increased CRP levels. 
      None of genotypes or alleles was associated with Gensini score. We found that the 
      haplotype 7 (AGCG) was associated with decreased risk of CAD (OR= 0.11; 95% CI: 
      0.02, 0.66; p= 0.017) and the Gensini score was correlated with increased levels 
      of CRP, only in CAD group. CONCLUSION: Although genetic polymorphisms were 
      influenced on serum RP levels, none of the alleles and genotypes raising or 
      falling C-reactive protein levels was consistently associated with an increased 
      prevalence of CAD or protected from that.
FAU - Ghaffari, Mohammad Ali
AU  - Ghaffari MA
AD  - Cellular and Molecular Research Center, Ahvaz Jondishapour University of Medical 
      Sciences, Ahwaz, Iran.
FAU - Askari Sede, Saeed
AU  - Askari Sede S
AD  - Department of Biochemistry, Faculty of Medicine, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Rashtchizadeh, Nadereh
AU  - Rashtchizadeh N
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
FAU - Mohammadzadeh, Ghorban
AU  - Mohammadzadeh G
AD  - Hyperlipidemia Research Center, Ahvaz Jondishapour University of Medical 
      Sciences, Ahvaz, Iran.
FAU - Majidi, Shahla
AU  - Majidi S
AD  - Department of Cardiology, Imam Khomeini Hospital, Ahvaz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20140927
PL  - Iran
TA  - Bioimpacts
JT  - BioImpacts : BI
JID - 101558125
PMC - PMC4204038
OTO - NOTNLM
OT  - C-reactive protein
OT  - Coronary artery disease
OT  - Gensini score
OT  - Polymorphism
OT  - Type2 diabetes mellitus
EDAT- 2014/10/23 06:00
MHDA- 2014/10/23 06:01
PMCR- 2014/01/01
CRDT- 2014/10/23 06:00
PHST- 2014/04/09 00:00 [received]
PHST- 2014/09/09 00:00 [revised]
PHST- 2014/09/13 00:00 [accepted]
PHST- 2014/10/23 06:00 [entrez]
PHST- 2014/10/23 06:00 [pubmed]
PHST- 2014/10/23 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.15171/bi.2014.006 [doi]
PST - ppublish
SO  - Bioimpacts. 2014;4(3):133-9. doi: 10.15171/bi.2014.006. Epub 2014 Sep 27.