PMID- 25338226
OWN - NLM
STAT- MEDLINE
DCOM- 20150608
LR  - 20191210
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 62
IP  - 45
DP  - 2014 Nov 12
TI  - Determination of four flavorings in infant formula by solid-phase extraction and 
      gas chromatography-tandem mass spectrometry.
PG  - 10881-8
LID - 10.1021/jf5013083 [doi]
AB  - Increasing attention has been focused on the artificial flavorings added in 
      foods, especially those for infants and children. For the first time, a sensitive 
      and efficient analytical method based on gas chromatography-tandem mass 
      spectrometry (GC-MS/MS) was developed for the simultaneous identification and 
      quantification of four flavoring agents (vanillin, methylvanillin, ethylvanillin, 
      and coumarin) in infant formula samples. The flavorings in samples were extracted 
      with methanol/water (v/v, 1:1), cleaned up by solid-phase extraction, and 
      determined by GC-MS/MS in selected reaction monitoring (SRM) mode. Both 
      isotope-labeled internal standards and matrix-matched calibration solutions were 
      used to correct the matrix effects. The limit of quantification (LOQ) was 
      calculated as 10 times the standard deviation, and it was 10.0 mug kg (-1) for 
      vanillin, methylvanillin, ethylvanillin, and coumarin. The average recoveries 
      were in the range of 82.8-107.5% with relative standard deviations (RSDs) below 
      8.9% measured at three concentration levels (10, 50, and 100 mug kg(-1)). The 
      proposed method is suitable for the sensitive and accurate simultaneous 
      determination of four flavoring agents in infant formula samples and also 
      provided potential use for reference in terms of real analysis of other foods.
FAU - Shen, Yan
AU  - Shen Y
AD  - College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou 
      325035, China.
FAU - Hu, Beizhen
AU  - Hu B
FAU - Chen, Xiangzhun
AU  - Chen X
FAU - Miao, Qian
AU  - Miao Q
FAU - Wang, Chengjun
AU  - Wang C
FAU - Zhu, Zhenou
AU  - Zhu Z
FAU - Han, Chao
AU  - Han C
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141031
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Benzaldehydes)
RN  - 0 (Coumarins)
RN  - 0 (Flavoring Agents)
RN  - A4VZ22K1WT (coumarin)
RN  - CHI530446X (vanillin)
SB  - IM
MH  - Benzaldehydes/chemistry/isolation & purification
MH  - Coumarins/chemistry/isolation & purification
MH  - Flavoring Agents/*chemistry/*isolation & purification
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Humans
MH  - Infant Formula/*chemistry
MH  - Molecular Structure
MH  - Solid Phase Extraction/*methods
OTO - NOTNLM
OT  - GC-MS/MS
OT  - SPE
OT  - flavorings
OT  - infant formula
EDAT- 2014/10/23 06:00
MHDA- 2015/06/09 06:00
CRDT- 2014/10/23 06:00
PHST- 2014/10/23 06:00 [entrez]
PHST- 2014/10/23 06:00 [pubmed]
PHST- 2015/06/09 06:00 [medline]
AID - 10.1021/jf5013083 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2014 Nov 12;62(45):10881-8. doi: 10.1021/jf5013083. Epub 2014 
      Oct 31.