PMID- 25339814
OWN - NLM
STAT- MEDLINE
DCOM- 20150624
LR  - 20220408
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 20
IP  - 39
DP  - 2014 Oct 21
TI  - Laparoscopic fundoplication for gastroesophageal reflux disease.
PG  - 14272-9
LID - 10.3748/wjg.v20.i39.14272 [doi]
AB  - Gastroesophageal reflux disease (GERD) is a condition that develops when the 
      reflux of gastric contents into the esophagus leads to troublesome symptoms 
      and/or complications. Heartburn is the cardinal symptom, often associated with 
      regurgitation. In patients with endoscopy-negative heartburn refractory to proton 
      pump inhibitor (PPI) therapy and when the diagnosis of GERD is in question, 
      direct reflux testing by impedance-pH monitoring is warranted. Laparoscopic 
      fundoplication is the standard surgical treatment for GERD. It is highly 
      effective in curing GERD with a 80% success rate at 20-year follow-up. The Nissen 
      fundoplication, consisting of a total (360 degrees ) wrap, is the most commonly performed 
      antireflux operation. To reduce postoperative dysphagia and gas bloating, partial 
      fundoplications are also used, including the posterior (Toupet) fundoplication, 
      and the anterior (Dor) fundoplication. Currently, there is consensus to advise 
      laparoscopic fundoplication in PPI-responsive GERD only for those patients who 
      develop untoward side-effects or complications from PPI therapy. PPI resistance 
      is the real challenge in GERD. There is consensus that carefully selected GERD 
      patients refractory to PPI therapy are eligible for laparoscopic fundoplication, 
      provided that objective evidence of reflux as the cause of ongoing symptoms has 
      been obtained. For this purpose, impedance-pH monitoring is regarded as the 
      diagnostic gold standard.
FAU - Frazzoni, Marzio
AU  - Frazzoni M
AD  - Marzio Frazzoni, Leonardo Frazzoni, Digestive Pathophysiology Unit, Baggiovara 
      Hospital, 41100 Modena, Italy.
FAU - Piccoli, Micaela
AU  - Piccoli M
AD  - Marzio Frazzoni, Leonardo Frazzoni, Digestive Pathophysiology Unit, Baggiovara 
      Hospital, 41100 Modena, Italy.
FAU - Conigliaro, Rita
AU  - Conigliaro R
AD  - Marzio Frazzoni, Leonardo Frazzoni, Digestive Pathophysiology Unit, Baggiovara 
      Hospital, 41100 Modena, Italy.
FAU - Frazzoni, Leonardo
AU  - Frazzoni L
AD  - Marzio Frazzoni, Leonardo Frazzoni, Digestive Pathophysiology Unit, Baggiovara 
      Hospital, 41100 Modena, Italy.
FAU - Melotti, Gianluigi
AU  - Melotti G
AD  - Marzio Frazzoni, Leonardo Frazzoni, Digestive Pathophysiology Unit, Baggiovara 
      Hospital, 41100 Modena, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Drug Resistance
MH  - Fundoplication/adverse effects/*methods
MH  - Gastroesophageal Reflux/diagnosis/*surgery
MH  - Humans
MH  - *Laparoscopy/adverse effects
MH  - Patient Selection
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Risk Factors
MH  - Treatment Outcome
PMC - PMC4202356
OTO - NOTNLM
OT  - Gastroesophageal reflux disease
OT  - Impedance-pH monitoring
OT  - Laparoscopic fundoplication
OT  - Proton pump inhibitors
OT  - Refractory gastroesophageal reflux disease
EDAT- 2014/10/24 06:00
MHDA- 2015/06/25 06:00
PMCR- 2014/10/21
CRDT- 2014/10/24 06:00
PHST- 2013/11/26 00:00 [received]
PHST- 2014/01/30 00:00 [revised]
PHST- 2014/05/12 00:00 [accepted]
PHST- 2014/10/24 06:00 [entrez]
PHST- 2014/10/24 06:00 [pubmed]
PHST- 2015/06/25 06:00 [medline]
PHST- 2014/10/21 00:00 [pmc-release]
AID - 10.3748/wjg.v20.i39.14272 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2014 Oct 21;20(39):14272-9. doi: 
      10.3748/wjg.v20.i39.14272.