PMID- 25340161
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141023
LR  - 20220318
IS  - 2345-2781 (Print)
IS  - 2345-2781 (Electronic)
IS  - 2345-2781 (Linking)
VI  - 3
IP  - 1
DP  - 2014
TI  - Efficacy of supplementary vitamin D on improvement of glycemic parameters in 
      patients with type 2 diabetes mellitus; a randomized double blind clinical trial.
PG  - 31-4
LID - 10.12861/jrip.2014.10 [doi]
AB  - INTRODUCTION: Studies have revealed the association between vitamin D deficiency 
      and changes in blood glucose and insulin levels as well as sensitivity of the 
      target tissues to insulin. OBJECTIVE: In this study, we examined the effect of 
      adding vitamin D (cholecalciferol ; 50,000 units) to therapeutic regimen of T2DM 
      patients compared to placebo on regulating the blood glucose and glycemic 
      parameters. PATIENTS AND METHODS: This study was a double blind clinical trial 
      conducted on 60 type 2 diabetes mellitus (T2DM) patients. Exclusion criteria were 
      taking calcium, vitamin D supplements or any drugs effecting calcium and vitamin 
      D metabolism in the past 6 months. Serum 25-Hydroxy vitamin D [25(OH)D] level was 
      measured with ELISA method. Patients were administered weekly vitamin D 
      supplementation (50000 units) for 12 weeks. RESULTS: There was no significant 
      relation between HbA1c and 25(OH)D level prior the study (p> 0.05). After 
      intervention, 25(OH)D level in interventional group was significantly higher 
      compared to that of control group. HbA1c in male interventional group was 
      significantly less than that of control group (p= 0.0068). CONCLUSION: Weekly 
      vitamin D supplementation had beneficial effect on glycemic parameters in male 
      type 2 diabetic patients.
FAU - Nasri, Hamid
AU  - Nasri H
AD  - Department of Nephrology, Division of Nephropathology, Isfahan University of 
      Medical Sciences, Isfahan, Iran.
FAU - Behradmanesh, Saeed
AU  - Behradmanesh S
AD  - Department of Internal Medicine, Shahrekord University of Medical Sciences, 
      Shahrekord, Iran.
FAU - Maghsoudi, Ahmad Reza
AU  - Maghsoudi AR
AD  - Department of Internal Medicine, Shahrekord University of Medical Sciences, 
      Shahrekord, Iran.
FAU - Ahmadi, Ali
AU  - Ahmadi A
AD  - Department of Epidemiology, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
FAU - Nasri, Parto
AU  - Nasri P
AD  - Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Rafieian-Kopaei, Mahmoud
AU  - Rafieian-Kopaei M
AD  - Medical Plants Research Center, Shahrekord University of Medical Sciences, 
      Shahrekord, Iran.
LA  - eng
PT  - Journal Article
DEP - 20131130
PL  - Iran
TA  - J Renal Inj Prev
JT  - Journal of renal injury prevention
JID - 101642540
PMC - PMC4206038
OTO - NOTNLM
OT  - HbA1c
OT  - Type 2 diabetes patients
OT  - Vitamin D
EDAT- 2014/10/24 06:00
MHDA- 2014/10/24 06:01
PMCR- 2013/11/30
CRDT- 2014/10/24 06:00
PHST- 2013/08/10 00:00 [received]
PHST- 2013/09/15 00:00 [accepted]
PHST- 2014/10/24 06:00 [entrez]
PHST- 2014/10/24 06:00 [pubmed]
PHST- 2014/10/24 06:01 [medline]
PHST- 2013/11/30 00:00 [pmc-release]
AID - 10.12861/jrip.2014.10 [doi]
PST - epublish
SO  - J Renal Inj Prev. 2013 Nov 30;3(1):31-4. doi: 10.12861/jrip.2014.10. eCollection 
      2014.