PMID- 25342157
OWN - NLM
STAT- MEDLINE
DCOM- 20150129
LR  - 20151119
IS  - 0001-5547 (Print)
IS  - 0001-5547 (Linking)
VI  - 58
IP  - 5
DP  - 2014
TI  - Fine-needle aspiration cytology of mammary analog secretory carcinoma 
      masquerading as low-grade mucoepidermoid carcinoma: case report with a review of 
      the literature.
PG  - 501-10
LID - 10.1159/000368070 [doi]
AB  - BACKGROUND/AIM: The primary role of fine-needle aspiration cytology (FNAC) of 
      salivary gland masses is to determine the underlying process and guide further 
      management. The objective of our study is to provide a comprehensive review of 
      cytologic features and ancillary studies of mammary analog secretory carcinoma 
      (MASC), discuss differential diagnosis and review recent advances in the 
      understanding of its biologic behavior. CASE: A 23-year-old female underwent 
      ultrasound-guided FNA of a slowly enlarging parotid mass. Smears displayed 
      branching clusters of bland vacuolated polygonal cells in a secretory 
      proteinaceous background. Eosinophilic cells with eccentric nuclei and 
      inconspicuous nucleoli were also noted. Based on positive intracellular mucin 
      staining and the lack of extracellular-matrix material, the cytologic diagnosis 
      rendered was 'suspicious for low grade mucoepidermoid carcinoma'. Superficial 
      parotidectomy revealed an MASC confirmed by fluorescence in situ hybridization 
      (FISH) studies for ETV6 translocation. CONCLUSION: MASC should be included in the 
      differential diagnosis of mucinous salivary lesions with cystic changes on FNA. 
      Immunohistochemistry for mammaglobin and S-100 helps in excluding morphologic 
      mimics. FISH helps to confirm the diagnosis. Age alone should not be a deterrent 
      in diagnosing a carcinoma.
CI  - (c) 2014 S. Karger AG, Basel.
FAU - Bajaj, Jaya
AU  - Bajaj J
AD  - Department of Pathology, North Shore-LIJ Health System, Lake Success, N.Y., USA.
FAU - Gimenez, Cecilia
AU  - Gimenez C
FAU - Slim, Farah
AU  - Slim F
FAU - Aziz, Mohamed
AU  - Aziz M
FAU - Das, Kasturi
AU  - Das K
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20141023
PL  - Switzerland
TA  - Acta Cytol
JT  - Acta cytologica
JID - 0370307
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (S100 Proteins)
RN  - 0 (Secretoglobins)
RN  - Secretory breast carcinoma
SB  - IM
MH  - Biomarkers, Tumor/*genetics
MH  - Biopsy, Fine-Needle
MH  - Breast Neoplasms/diagnosis/pathology
MH  - Carcinoma/diagnosis/pathology
MH  - Carcinoma, Acinar Cell/*diagnosis/genetics/pathology
MH  - Carcinoma, Mucoepidermoid/diagnosis/pathology
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Parotid Gland/metabolism/*pathology
MH  - S100 Proteins/*genetics
MH  - Salivary Gland Neoplasms/*diagnosis/genetics/pathology
MH  - Secretoglobins/*genetics
MH  - Young Adult
EDAT- 2014/10/25 06:00
MHDA- 2015/01/30 06:00
CRDT- 2014/10/25 06:00
PHST- 2014/04/25 00:00 [received]
PHST- 2014/09/01 00:00 [accepted]
PHST- 2014/10/25 06:00 [entrez]
PHST- 2014/10/25 06:00 [pubmed]
PHST- 2015/01/30 06:00 [medline]
AID - 000368070 [pii]
AID - 10.1159/000368070 [doi]
PST - ppublish
SO  - Acta Cytol. 2014;58(5):501-10. doi: 10.1159/000368070. Epub 2014 Oct 23.