PMID- 25342194
OWN - NLM
STAT- MEDLINE
DCOM- 20150615
LR  - 20141027
IS  - 1875-5607 (Electronic)
IS  - 1389-5575 (Linking)
VI  - 14
IP  - 10
DP  - 2014
TI  - Hepatic microRNA orchestra: a new diagnostic, prognostic and theranostic tool for 
      hepatocarcinogenesis.
PG  - 837-52
AB  - MicroRNAs are evolutionary conserved single stranded non-coding RNAs with immense 
      ability to posttranscriptionally regulate gene expression via complementary base 
      pairing with mRNAs of more than 50% protein encoding genes. They play diverse 
      roles in physiological and pathophysiological processes such as normal 
      development and cancer pathogenesis respectively. Recent investigations have 
      focused on the identification and characterization of microRNAs aberrantly 
      expressed in cancer and their target molecules that are critically involved in 
      the initiation, progression and development of carcinogenesis as possible 
      diagnostic, prognostic and theranostic (Integration of biomarker use as 
      diagnostic tools and target-specific therapies to enhance selective and 
      individualized therapy) tools to augment conventional cancer therapeutic 
      armamentarium. In this mini review, we bring to focus the intricate interactions 
      between microRNAs aberrantly expressed in hepatocarcinogenesis and their 
      interactions with the transforming growth factor beta (TGF-beta)/Small mother 
      against decapentaplegic (Smad) and the mitogen activated protein kinases (MAPKs) 
      signaling pathways. Importantly, we highlight microRNA-Specific targets as 
      possible biomarkers for prognosis, diagnosis and as therapeutic targets for 
      hepatocellular carcinoma (HCC) while at the same time exploring new directions 
      for future investigations.
FAU - Boye, Alex
AU  - Boye A
FAU - Yang, Yan
AU  - Yang Y
AD  - Department of Pharmacology, Anhui Medical University, Hefei, China. 
      yangyan@ahmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Mini Rev Med Chem
JT  - Mini reviews in medicinal chemistry
JID - 101094212
RN  - 0 (MicroRNAs)
RN  - 0 (Smad Proteins)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Animals
MH  - Carcinoma, Hepatocellular/diagnosis/*genetics/pathology/therapy
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Liver/metabolism/pathology
MH  - Liver Neoplasms/diagnosis/*genetics/pathology/therapy
MH  - MicroRNAs/*genetics/metabolism
MH  - Prognosis
MH  - Signal Transduction
MH  - Smad Proteins/metabolism
MH  - Transforming Growth Factor beta/metabolism
EDAT- 2014/10/25 06:00
MHDA- 2015/06/16 06:00
CRDT- 2014/10/25 06:00
PHST- 2014/06/19 00:00 [received]
PHST- 2014/09/22 00:00 [revised]
PHST- 2014/09/23 00:00 [accepted]
PHST- 2014/10/25 06:00 [entrez]
PHST- 2014/10/25 06:00 [pubmed]
PHST- 2015/06/16 06:00 [medline]
AID - MRMC-EPUB-63045 [pii]
PST - ppublish
SO  - Mini Rev Med Chem. 2014;14(10):837-52.