PMID- 25342636
OWN - NLM
STAT- MEDLINE
DCOM- 20151125
LR  - 20211021
IS  - 1347-7439 (Electronic)
IS  - 0916-7250 (Print)
IS  - 0916-7250 (Linking)
VI  - 77
IP  - 2
DP  - 2015 Feb
TI  - Electroacupuncture at the Zusanli and Baihui acupoints ameliorates type-2 
      diabetes-induced reductions in proliferating cells and differentiated neuroblasts 
      in the hippocampal dentate gyrus with increasing brain-derived neurotrophic 
      factor levels.
PG  - 167-73
LID - 10.1292/jvms.14-0400 [doi]
AB  - In the current study, we investigated whether electroacupuncture (EA) can inhibit 
      pathological reductions in neurogenesis. Zucker diabetic fatty (ZDF) rats at 7 
      weeks of age were anesthetized with zoletil, and sham-acupuncture or EA at the 
      Zusanli (ST36) and Baihui (GV20) acupoints was administered once a day for 5 
      weeks. In the ZDF group that received sham-EA (ZDF-Sham group), the blood glucose 
      level was significantly increased together with age as compared to the control 
      littermates [Zucker lean control (ZLC) rat]. In contrast, proliferating cells and 
      differentiated neuroblasts were significantly decreased in the ZDF-Sham group 
      compared to the ZLC group. Although EA treatment decreased blood glucose levels, 
      this was not statistically significant when compared to blood glucose levels 
      changes in the ZDF-Sham group. However, proliferating cells and differentiated 
      neuroblasts were significantly increased with EA in ZDF rats as compared to those 
      in the ZDF-Sham group. Brain-derived neurotrophic factor (BDNF) levels were 
      significantly decreased in hippocampal homogenates of ZDF-Sham group compared to 
      those in the ZLC group. The EA treatment significantly increased the BDNF levels 
      compared to those in the ZDF-Sham group, and BDNF levels in this group were 
      similar to those in the ZLC group. These results suggest that EA at ST36 and GV20 
      can ameliorate the reductions in proliferating cells and differentiated 
      neuroblasts in the dentate gyrus induced by type-2 diabetes without significantly 
      reducing blood glucose levels with increasing BDNF levels.
FAU - Chung, Jin Young
AU  - Chung JY
AD  - Department of Veterinary Internal Medicine and Geriatrics, College of Veterinary 
      Medicine, Kangwon National University, Chuncheon 200-701, Republic of Korea.
FAU - Yoo, Dae Young
AU  - Yoo DY
FAU - Im, Wooseok
AU  - Im W
FAU - Choi, Jung Hoon
AU  - Choi JH
FAU - Yi, Sun Shin
AU  - Yi SS
FAU - Youn, Hwa Young
AU  - Youn HY
FAU - Hwang, In Koo
AU  - Hwang IK
FAU - Seong, Je Kyung
AU  - Seong JK
FAU - Yoon, Yeo Sung
AU  - Yoon YS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141022
PL  - Japan
TA  - J Vet Med Sci
JT  - The Journal of veterinary medical science
JID - 9105360
RN  - 0 (Blood Glucose)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Acupuncture Therapy/*methods
MH  - Animals
MH  - Blood Glucose
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cell Differentiation
MH  - Cell Proliferation
MH  - Dentate Gyrus/cytology/*physiology
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - *Electric Stimulation
MH  - Female
MH  - Male
MH  - Neurons/cytology/*physiology
MH  - Rats
MH  - Rats, Zucker
PMC - PMC4363018
EDAT- 2014/10/25 06:00
MHDA- 2015/12/15 06:00
PMCR- 2015/02/01
CRDT- 2014/10/25 06:00
PHST- 2014/10/25 06:00 [entrez]
PHST- 2014/10/25 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2015/02/01 00:00 [pmc-release]
AID - DN/JST.JSTAGE/jvms/14-0400 [pii]
AID - 14-0400 [pii]
AID - 10.1292/jvms.14-0400 [doi]
PST - ppublish
SO  - J Vet Med Sci. 2015 Feb;77(2):167-73. doi: 10.1292/jvms.14-0400. Epub 2014 Oct 
      22.