PMID- 25343267
OWN - NLM
STAT- MEDLINE
DCOM- 20151222
LR  - 20181217
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 123
IP  - 3
DP  - 2015 Mar
TI  - The relationship between serum calcium level and early-phase insulin secretion in 
      normoglycemic and pre-diabetic individuals.
PG  - 165-9
LID - 10.1055/s-0034-1394382 [doi]
AB  - INTRODUCTION: Type 2 diabetes mellitus (T2DM) is linked to altered calcium 
      metabolism. However, little is known about the relationship between serum calcium 
      levels and early-phase insulin secretion in subjects with normoglycemic tolerance 
      (NGT) or prediabetes (preDM). METHODS: In this gender-separated cross-sectional 
      study, 352 subjects with NGT (215 men and 137 women; age: 48.8+/-9.1 years and 
      51.6+/-6.7 years, respectively) and 316 subjects with preDM (231 men and 85 women; 
      age: 52.5+/-8.6 years and 54.2+/-8.0 years, respectively) were examined. Following a 
      75-g oral glucose tolerance test, early-phase insulin secretion was estimated 
      using the insulinogenic index (IGI) [DeltaInsulin(30-0 min)/DeltaGlucose(30-0 min)]. 
      RESULTS: Simple linear regression analysis showed that IGI was positively 
      correlated with serum calcium and albumin-adjusted calcium levels in men with NGT 
      and preDM. However, IGI was not correlated with calcium levels in women with NGT 
      and preDM. Multivariate linear regression analysis of men with NGT revealed that 
      the albumin-adjusted calcium level was the major predictor of IGI, responsible 
      for 5.1% of its variation (P=0.003). In addition, in men with preDM, the 
      albumin-adjusted calcium level was one of the predictors of IGI, responsible for 
      3.8% of its variation (P=0.004). These associations were independent of age, BMI, 
      and HbA1c. CONCLUSIONS: In non-diabetic Japanese men, serum calcium levels 
      significantly correlate with early-phase insulin secretion. Serum calcium levels 
      may be an independent predictor of beta-cell function in men.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Shimodaira, M
AU  - Shimodaira M
AD  - Department of Internal Medicine, Iida Municipal Hospital, Nagano, Japan.
FAU - Niwa, T
AU  - Niwa T
AD  - Department of Internal Medicine, Iida Municipal Hospital, Nagano, Japan.
FAU - Nakajima, K
AU  - Nakajima K
AD  - Department of Internal Medicine, Iida Municipal Hospital, Nagano, Japan.
FAU - Kobayashi, M
AU  - Kobayashi M
AD  - Department of Internal Medicine, Iida Municipal Hospital, Nagano, Japan.
FAU - Hanyu, N
AU  - Hanyu N
AD  - Department of Internal Medicine, Iida Municipal Hospital, Nagano, Japan.
FAU - Nakayama, T
AU  - Nakayama T
AD  - Department of Pathology and Microbiology, Division of Laboratory Medicine, Nihon 
      University School of Medicine, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20141024
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (Insulin)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adult
MH  - Calcium/*blood
MH  - Female
MH  - Humans
MH  - Insulin/*metabolism
MH  - Insulin Secretion
MH  - Male
MH  - Middle Aged
MH  - Prediabetic State/*blood
MH  - Sex Factors
EDAT- 2014/10/25 06:00
MHDA- 2015/12/23 06:00
CRDT- 2014/10/25 06:00
PHST- 2014/10/25 06:00 [entrez]
PHST- 2014/10/25 06:00 [pubmed]
PHST- 2015/12/23 06:00 [medline]
AID - 10.1055/s-0034-1394382 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2015 Mar;123(3):165-9. doi: 10.1055/s-0034-1394382. 
      Epub 2014 Oct 24.