PMID- 25343819
OWN - NLM
STAT- MEDLINE
DCOM- 20151019
LR  - 20211025
IS  - 1660-2110 (Electronic)
IS  - 1660-2110 (Linking)
VI  - 127
IP  - 1-4
DP  - 2014
TI  - Mitochondrial biogenesis in the acutely injured kidney.
PG  - 42-5
LID - 10.1159/000363715 [doi]
AB  - Mitochondrial dysfunction within the tubular epithelium has been implicated in 
      the pathogenesis of acute kidney injury. Inflammatory, ischemic, or toxic insults 
      dysregulate mitochondrial dynamics, resulting in mitochondrial swelling, fission, 
      and apoptosis. The coordinated processes of generating healthy mitochondria and 
      clearing damaged organelles may contribute to the preservation and restoration of 
      mitochondrial homeostasis. Emerging literature suggests that a master regulator 
      of mitochondrial biogenesis, peroxisome proliferator-activated 
      receptor-gamma-coactivator-1alpha (PGC-1alpha), is highly expressed in the tubular epithelium 
      of the healthy kidney, and its induction during the post-injury period may 
      contribute to functional recovery from acute kidney injury.
CI  - 2014 S. Karger AG, Basel.
FAU - Tran, Mei
AU  - Tran M
AD  - Division of Nephrology and Center for Vascular Biology Research, Department of 
      Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 
      Boston, Mass., USA.
FAU - Parikh, Samir M
AU  - Parikh SM
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140924
PL  - Switzerland
TA  - Nephron Clin Pract
JT  - Nephron. Clinical practice
JID - 101159763
RN  - 0 (PPAR gamma)
RN  - 0 (PPARGC1A protein, human)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Ppargc1a protein, mouse)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Acute Kidney Injury/etiology/metabolism/*pathology/therapy
MH  - Animals
MH  - Endotoxemia/pathology/physiopathology
MH  - Energy Metabolism
MH  - Epithelial Cells/pathology
MH  - Humans
MH  - Kidney Tubules, Proximal/metabolism/pathology
MH  - Mice, Knockout
MH  - Mitochondria/physiology
MH  - *Mitochondrial Turnover/drug effects
MH  - Molecular Targeted Therapy
MH  - PPAR gamma/physiology
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
MH  - Renal Replacement Therapy
MH  - Sepsis/complications
MH  - Transcription Factors/antagonists & inhibitors/deficiency/physiology
EDAT- 2014/10/25 06:00
MHDA- 2015/10/20 06:00
CRDT- 2014/10/25 06:00
PHST- 2014/10/25 06:00 [entrez]
PHST- 2014/10/25 06:00 [pubmed]
PHST- 2015/10/20 06:00 [medline]
AID - 000363715 [pii]
AID - 10.1159/000363715 [doi]
PST - ppublish
SO  - Nephron Clin Pract. 2014;127(1-4):42-5. doi: 10.1159/000363715. Epub 2014 Sep 24.