PMID- 25344129
OWN - NLM
STAT- MEDLINE
DCOM- 20150713
LR  - 20141210
IS  - 1752-8984 (Electronic)
IS  - 1479-1641 (Linking)
VI  - 12
IP  - 1
DP  - 2015 Jan
TI  - All-cause mortality and estimated renal function in type 2 diabetes mellitus 
      outpatients: Is there a relationship with the equation used?
PG  - 46-52
LID - 10.1177/1479164114552656 [doi]
AB  - BACKGROUND: We investigated the relationship between serum creatinine (SCr) and 
      estimated glomerular filtration rate (eGFR), evaluated by different formulae, and 
      all-cause mortality (ACM) in type 2 diabetes mellitus (T2DM) outpatients. 
      METHODS: This observational cohort study considered 1365 T2DM outpatients, who 
      had been followed up for a period of up to 11 years. eGFR was estimated using 
      several equations. RESULTS: Seventy subjects (5.1%) died after a follow-up of 9.8 
      +/- 3 years. Univariate analysis showed that diagnosis of nephropathy (odds ratio 
      (OR): 2.554, 95% confidence interval (CI): 1.616-4.038, p < 0.001) and 
      microvascular complications (OR: 2.281, 95% CI: 1.449-3.593, p < 0.001) were 
      associated with ACM. Receiving operating characteristic (ROC) curves showed that 
      the areas under the curve for ACM were similar using the different eGFR 
      equations. eGFR values were predictors of ACM, and the hazard ratios (HRs) of the 
      different equations for eGFR estimation were similar. CONCLUSION: In our cohort 
      of T2DM outpatients, different eGFR equations perform similarly in predicting 
      ACM, whereas SCr did not.
CI  - (c) The Author(s) 2014.
FAU - Fabbian, Fabio
AU  - Fabbian F
AD  - Operative Unit of Clinica Medica, Department of Medical Sciences, University 
      Hospital St. Anna, Ferrara, Italy f.fabbian@ospfe.it.
FAU - De Giorgi, Alfredo
AU  - De Giorgi A
AD  - Operative Unit of Clinica Medica, Department of Medical Sciences, University 
      Hospital St. Anna, Ferrara, Italy.
FAU - Monesi, Marcello
AU  - Monesi M
AD  - Diabetes and Clinical Nutrition, University Hospital St. Anna, Ferrara, Italy.
FAU - Pala, Marco
AU  - Pala M
AD  - Operative Unit of Clinica Medica, Department of Medical Sciences, University 
      Hospital St. Anna, Ferrara, Italy.
FAU - Tiseo, Ruana
AU  - Tiseo R
AD  - Operative Unit of Clinica Medica, Department of Medical Sciences, University 
      Hospital St. Anna, Ferrara, Italy.
FAU - Misurati, Elisa
AU  - Misurati E
AD  - Operative Unit of Clinica Medica, Department of Medical Sciences, University 
      Hospital St. Anna, Ferrara, Italy.
FAU - Parisi, Claudia
AU  - Parisi C
AD  - Operative Unit of Clinica Medica, Department of Medical Sciences, University 
      Hospital St. Anna, Ferrara, Italy.
FAU - Volpi, Riccardo
AU  - Volpi R
AD  - Department of Internal Medicine and Biomedical Science, University of Parma, 
      Parma, Italy.
FAU - Graziani, Roberto
AU  - Graziani R
AD  - Diabetes and Clinical Nutrition, University Hospital St. Anna, Ferrara, Italy.
FAU - Mikhailidis, Dimitri P
AU  - Mikhailidis DP
AD  - Department of Clinical Biochemistry (Vascular Disease Prevention Clinics), 
      University College London Medical School, University College London (UCL), 
      London, UK.
FAU - Manfredini, Roberto
AU  - Manfredini R
AD  - Operative Unit of Clinica Medica, Department of Medical Sciences, University 
      Hospital St. Anna, Ferrara, Italy.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20141024
PL  - England
TA  - Diab Vasc Dis Res
JT  - Diabetes & vascular disease research
JID - 101234011
SB  - IM
MH  - Aged
MH  - Algorithms
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*complications/diagnosis/mortality
MH  - Diabetic Angiopathies/complications/diagnosis/mortality/physiopathology
MH  - Diabetic Nephropathies/diagnosis/mortality/*physiopathology
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Hospitals, University
MH  - Humans
MH  - Italy/epidemiology
MH  - Kidney/*physiopathology
MH  - Longitudinal Studies
MH  - Male
MH  - Microvessels/physiopathology
MH  - Middle Aged
MH  - Mortality
MH  - Outpatient Clinics, Hospital
MH  - Peripheral Vascular Diseases/complications/diagnosis/mortality/physiopathology
MH  - Prognosis
MH  - Renal Insufficiency/*complications/diagnosis/mortality/physiopathology
MH  - Survival Analysis
OTO - NOTNLM
OT  - Type 2 diabetes mellitus
OT  - all-cause mortality
OT  - equations
OT  - glomerular filtration rate
OT  - kidney
OT  - outpatients
EDAT- 2014/10/26 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/10/26 06:00
PHST- 2014/10/26 06:00 [entrez]
PHST- 2014/10/26 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 1479164114552656 [pii]
AID - 10.1177/1479164114552656 [doi]
PST - ppublish
SO  - Diab Vasc Dis Res. 2015 Jan;12(1):46-52. doi: 10.1177/1479164114552656. Epub 2014 
      Oct 24.