PMID- 25344634
OWN - NLM
STAT- MEDLINE
DCOM- 20150827
LR  - 20231213
IS  - 1347-4715 (Electronic)
IS  - 1342-078X (Print)
IS  - 1342-078X (Linking)
VI  - 20
IP  - 1
DP  - 2015 Jan
TI  - Useful biomarkers for assessing the adverse health effects of PCBs in allergic 
      children: pediatric molecular epidemiology.
PG  - 3-11
LID - 10.1007/s12199-014-0419-1 [doi]
AB  - The incidences of childhood allergies have been increasing in recent years in 
      many parts of the world. The development of allergic disorders is attributed to a 
      complex series of interactions between individuals' genetic backgrounds and their 
      immune and psychoneurotic responses to environmental factors. Among the various 
      possible environmental causes of childhood allergies, the early exposure of 
      developing infants to air pollutants and the presence of persistent chemical 
      pollutants such as pesticides have been suggested most frequently. Therefore, it 
      is very important to obtain epidemiological evidence of direct associations 
      between clearly defined adverse health effects and exposure to low levels of 
      pollutants. However, there are no useful biomarkers for assessing such 
      associations. Thus, we planned to establish reliable health-related biomarkers 
      that could be used to investigate these relationships in children. The serum 
      concentrations of several sub-types of polychlorinated biphenyl (PCB) congeners 
      were found to be significantly correlated with interleukin (IL)-8 mRNA expression 
      among asthmatic children. In addition, IL-22 mRNA expression was found to be 
      particularly useful for detecting the effects of environmental pollutants, 
      especially PCB congeners, in a sub-population of vulnerable children who 
      exhibited positive immunoglobulin E (IgE) responses to milk or egg. Furthermore, 
      we detected significant differences in IL-22 mRNA expression between the 
      IgE-negative non-asthmatic subjects and the asthmatic children who exhibited 
      positive IgE reactions toward egg or milk. In conclusion, IL-8 and IL-22 mRNA 
      expressions could be useful biomarkers for detecting sub-populations of children 
      who are particularly vulnerable to the adverse health effects of environmental 
      pollutants, especially PCBs.
FAU - Tsuji, Mayumi
AU  - Tsuji M
AD  - Department of Environmental Health, University of Occupational and Environmental 
      Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyusyu, 807-8555, Japan, 
      tsuji@med.uoeh-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20141026
PL  - Japan
TA  - Environ Health Prev Med
JT  - Environmental health and preventive medicine
JID - 9609642
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-8)
RN  - 0 (Interleukins)
RN  - 0 (RNA, Messenger)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Asthma
MH  - Biomarkers/*blood
MH  - Child, Preschool
MH  - Environmental Exposure/adverse effects/analysis
MH  - Humans
MH  - Hypersensitivity/*blood
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Interleukin-8/*blood
MH  - Interleukins/*blood
MH  - Japan
MH  - Milk
MH  - Molecular Epidemiology
MH  - Polychlorinated Biphenyls/*adverse effects/*blood
MH  - RNA, Messenger/blood
MH  - Real-Time Polymerase Chain Reaction
MH  - Interleukin-22
PMC - PMC4284252
EDAT- 2014/10/27 06:00
MHDA- 2015/08/28 06:00
PMCR- 2016/01/01
CRDT- 2014/10/27 06:00
PHST- 2014/09/18 00:00 [received]
PHST- 2014/09/30 00:00 [accepted]
PHST- 2014/10/27 06:00 [entrez]
PHST- 2014/10/27 06:00 [pubmed]
PHST- 2015/08/28 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 419 [pii]
AID - 10.1007/s12199-014-0419-1 [doi]
PST - ppublish
SO  - Environ Health Prev Med. 2015 Jan;20(1):3-11. doi: 10.1007/s12199-014-0419-1. 
      Epub 2014 Oct 26.