PMID- 25344653
OWN - NLM
STAT- MEDLINE
DCOM- 20150729
LR  - 20240509
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 14
DP  - 2014 Oct 26
TI  - Effect modification by gender and smoking status on the association between 
      obesity and atopic sensitization in Chinese adults: a hospital-based case-control 
      study.
PG  - 1105
LID - 10.1186/1471-2458-14-1105 [doi]
LID - 1105
AB  - BACKGROUND: There is an ongoing debate on the potential association between 
      obesity and atopy. However, no previous studies have investigated whether this 
      relationship depends on sex and smoking status in Chinese adults. METHODS: In 
      this hospital-based, case-control study, we recruited 1150 atopic cases aged 
      18 years or older and 1245 healthy control participants during April 2009 and 
      December 2012 in Harbin, China. We conducted structured questionnaire interviews, 
      anthropometry measurements and serum allergen-specific immunoglobulin E (IgE) 
      testing. Univariate and multivariate logistic regression models were used to 
      explore the relationship between obesity and atopy risk stratified by sex and 
      smoking status. RESULTS: There was an association between obesity and an 
      increased risk of atopic sensitization after adjusting for age, educational, 
      family history, smoking and alcohol consumption (OR: 2.61, 3.25; 95% CI: 
      1.57-4.33,1.91-5.56 in males and females, respectively). The association between 
      BMI and allergic sensitization depended on smoking status. In both genders, the 
      association of obesity with atopic sensitization risk was stronger in non-smokers 
      than in current smokers. In males, ORs of atopic sensitization for obesity were 
      3.15 (95% CI, 1.46-6.68) for non-smokers and 2.22 (95% CI, 1.10-4.48) for current 
      smokers. The corresponding ORs in females were 3.51 (95% CI, 1.98-6.24) and 2.22 
      (95% CI, 0.46-10.68) for non-smokers and current smokers, respectively. After 
      excluding those subjects who with pre-existing allergic conditions, the same 
      relationship still remained. CONCLUSIONS: Obesity is positively and significantly 
      associated with the risk of atopy in both men and women as well in both smokers 
      and non-smokers in China. In addition, the relationship between obesity and 
      atopic sensitization is stronger in non-smokers than in current smokers.
FAU - Luo, Xiao
AU  - Luo X
FAU - Wang, Yupeng
AU  - Wang Y
FAU - Wang, Zhiqiang
AU  - Wang Z
FAU - Zhou, Xiao-Hua
AU  - Zhou XH
FAU - Zhao, Jing
AU  - Zhao J
FAU - Suo, Jianing
AU  - Suo J
FAU - Dong, Xiaohui
AU  - Dong X
FAU - Liu, Meina
AU  - Liu M
AD  - Public Health College, Harbin Medical University, 157 Baojian Road, Harbin City, 
      Heilongjiang Province Postcode 150081, P,R, China. liumeina369@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141026
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alcohol Drinking
MH  - Asian People
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Dermatitis, Atopic/complications/*epidemiology
MH  - Female
MH  - Hospitals
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications/*epidemiology
MH  - Risk Factors
MH  - Sex Factors
MH  - *Smoking
MH  - Surveys and Questionnaires
PMC - PMC4228147
EDAT- 2014/10/27 06:00
MHDA- 2015/07/30 06:00
PMCR- 2014/10/26
CRDT- 2014/10/27 06:00
PHST- 2013/11/13 00:00 [received]
PHST- 2014/10/21 00:00 [accepted]
PHST- 2014/10/27 06:00 [entrez]
PHST- 2014/10/27 06:00 [pubmed]
PHST- 2015/07/30 06:00 [medline]
PHST- 2014/10/26 00:00 [pmc-release]
AID - 1471-2458-14-1105 [pii]
AID - 7211 [pii]
AID - 10.1186/1471-2458-14-1105 [doi]
PST - epublish
SO  - BMC Public Health. 2014 Oct 26;14:1105. doi: 10.1186/1471-2458-14-1105.