PMID- 25344752
OWN - NLM
STAT- MEDLINE
DCOM- 20150625
LR  - 20211021
IS  - 1573-2630 (Electronic)
IS  - 0165-5701 (Linking)
VI  - 34
IP  - 6
DP  - 2014 Dec
TI  - The expression of vascular endothelial growth factor in pterygium tissue of 
      atopic patients.
PG  - 1175-81
LID - 10.1007/s10792-013-9876-6 [doi]
AB  - The exact pathogenesis of pterygium has not been completely elucidated. Growth 
      factors have been considered to play a role in pterygium formation. Vascular 
      endothelial growth factor (VEGF) is one of the principal mediators of 
      angiogenesis, fibroblast stimulation and tissue remodeling in allergic 
      conditions. The aim of this study was to compare the association between 
      pterygium and VEGF gene expression between atopic and non-atopic individuals. At 
      first visit, all patients with pterygium underwent blood tests, serum 
      immunoglobulin E (IgE), serum cytokines including interleukin-4 (IL-4) and 
      interferon-gamma (IFN-gamma) and peripheral blood eosinophil count. After obtaining 
      informed consents, questionnaires were used to obtain demographic and clinical 
      data from patients who underwent pterygium excision surgery. Skin prick test was 
      performed to confirm or rule out atopy in 30 patients with (case group) and 30 
      patients without (control group) atopy. Pterygium tissues were then removed by 
      surgery. A semi-quantitative reverse transcriptase polymerase chain reaction was 
      performed to determine VEGF gene expression in all patients. Our results 
      illustrated that VEGF mRNA expression in atopic patients was significantly higher 
      than in the non-atopic group (P = 0.01). Eosinophil count, serum IgE and IL-4 
      were also significantly higher in atopic patients than in the non-atopic group (P 
      = 0.03, 0.001 and 0.001, respectively). However, no significant difference was 
      noted in serum IFN-gamma between the two groups (P = 0.06). The excessive expression 
      of VEGF gene in pterygium tissue of patients with atopy suggests that growth 
      factors may play a role in the pathogenesis of pterygium or accelerate its 
      formation.
FAU - Gharaee, Hamid
AU  - Gharaee H
AD  - Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Shayegan, Mohammad Reza
AU  - Shayegan MR
FAU - Khakzad, Mohammad Reza
AU  - Khakzad MR
FAU - Kianoush, Sina
AU  - Kianoush S
FAU - Varasteh, A-Reza
AU  - Varasteh AR
FAU - Sankian, Mojtaba
AU  - Sankian M
FAU - Meshkat, Mojtaba
AU  - Meshkat M
LA  - eng
PT  - Journal Article
DEP - 20141026
PL  - Netherlands
TA  - Int Ophthalmol
JT  - International ophthalmology
JID - 7904294
RN  - 0 (Cytokines)
RN  - 0 (RNA, Messenger)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cytokines/metabolism
MH  - Eosinophils/cytology
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/*metabolism
MH  - Immunoglobulin E/metabolism
MH  - Male
MH  - Middle Aged
MH  - Pterygium/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Vascular Endothelial Growth Factor A/*metabolism
EDAT- 2014/10/27 06:00
MHDA- 2015/06/26 06:00
CRDT- 2014/10/27 06:00
PHST- 2013/05/21 00:00 [received]
PHST- 2013/10/23 00:00 [accepted]
PHST- 2014/10/27 06:00 [entrez]
PHST- 2014/10/27 06:00 [pubmed]
PHST- 2015/06/26 06:00 [medline]
AID - 10.1007/s10792-013-9876-6 [doi]
PST - ppublish
SO  - Int Ophthalmol. 2014 Dec;34(6):1175-81. doi: 10.1007/s10792-013-9876-6. Epub 2014 
      Oct 26.